Anxiety Disorders: Introduction

Anxiety Disorders: Introduction
Anxiety represents a core phenomenon around which considerable psychiatric theory has been organized. Anxiety refers to brain states elicited by signals that predict impending but not immediately present danger. Anxiety involves sustained change in the brain, manifest when a threat is still relatively removed from the organism in a spatial or temporal context.

Epidemiology of Anxiety Disorders
Panic Disorder Most studies yield 12-month prevalence rates between 0.2 and 1.1 percent. The highest rate was reported in the NCS-R Study in the United States (2.7 percent), whereas the lowest 12-month prevalence was reported in Nigeria (0.1 percent). The lifetime prevalence rates of panic disorder range from 0.2 percent in Nigeria to a high of 3.9 percent in Germany, with most studies falling between 1 and 2 percent.

Generalized Anxiety Disorder Although the 12-month prevalence of GAD falls between 2.1 and 3.1 percent in both large-scale studies of the United States (National Epidemiologic Survey on Alcohol and Related Conditions [NESARC] and NCS-R), rates in other areas of the world ranged from 0 percent in Nigeria to 2.6 percent in Germany. The lifetime prevalence of GAD was even more variable, with the lowest rate reported in Nigeria (0.1 percent) and the highest in Italy (6.9 percent), with a median of approximately 2.3 percent.

Agoraphobia Apart from an elevated 12-month prevalence of agoraphobia reported in South Africa (4.8 percent), the rates of agoraphobia were remarkably consistent across regions. Nine separate international studies reported estimates ranging from 0 percent (China) to 0.8 percent (United States). The lifetime prevalence estimates were similarly consistent, with the lifetime prevalence of DSM-IV agoraphobia ranging anywhere from 0 percent (China) to 1.2 percent of the population (Italy and New Zealand).

Social Phobia The 12-month prevalence of social phobia varied across regions, with the highest rates reported in the U.S. NCS-R study (6.8 percent) and the lowest appearing in the Asian countries (Korea, 0.2 percent; China, 0.2 percent). The estimates for the lifetime prevalence of DSM-IV social phobia were also inconsistent across studies, with the range spanning from 0.2 percent in Korea to a high of 9.4 percent in New Zealand. Few of the other studies, however, reported lifetime prevalence estimates greater than 3 percent.

Specific Phobia The 12-month prevalence estimates ranged from 1.9 percent (China) to 8.7 percent (United States). Estimates for lifetime specific phobia were lowest in Italy (1.5 percent) and highest in New Zealand (10.8 percent).

Obsessive-Compulsive Disorder (OCD) The 12-month prevalence is very low, with a range of rates from 0.1 percent (Lebanon and Nigeria) to 1.0 percent (United States). Lifetime prevalence was also rather low, ranging from 0.1 percent (Nigeria) to 2.4 percent (Italy).

Panic Disorder and Agorophobia
Recurrent “panic attacks” represent the hallmark feature of panic disorder. The panic attack is defined as an episode of abrupt intense fear accompanied by at least four of the autonomic or cognitive symptoms

Criteria for Panic Attack
A discrete period of intense fear or discomfort, in which four (or more) of the following symptoms developed abruptly and reached a peak within 10 minutes: palpitations, pounding heart, or accelerated heart rate sweating trembling or shaking sensations of shortness of breath or smothering feeling of choking chest pain or discomfort

Criteria for Panic Attack
nausea or abdominal distress feeling dizzy, unsteady, lightheaded, or faint derealization (feelings of unreality) or depersonalization (being detached from oneself) fear of losing control or going crazy fear of dying paresthesias chills or hot flashes

Criteria for Agoraphobia
Anxiety about being in places or situations from which escape might be difficult (or embarrassing) or in which help may not be available in the event of having an unexpected or situationally predisposed Panic Attack or panic-like symptoms. Agoraphobic fears typically involve characteristic clusters of situations that include being outside the home alone; being in a crowd or standing in a line; being on a bridge; and traveling in a bus, train, or automobile. Note: Consider the diagnosis of Specific Phobia if the avoidance is limited to one or only a few specific situations, or Social Phobia if the avoidance is limited to social situations.

Criteria for Agoraphobia
The situations are avoided (e.g., travel is restricted) or else are endured with marked distress or with anxiety about having a Panic Attack or panic-like symptoms, or require the presence of a companion. The anxiety or phobic avoidance is not better accounted for by another mental disorder, such as Social Phobia (e.g., avoidance limited to social situations because of fear of embarrassment), Specific Phobia (e.g., avoidance limited to a single situation like elevators), Obsessive-Compulsive Disorder (e.g., avoidance of dirt in someone with an obsession about contamination), Posttraumatic Stress disorder (e.g., avoidance of stimuli associated with a severe stressor), or Separation Anxiety Disorder (e.g., avoidance of leaving home or relatives).

Criteria for Panic Disorder Without or With Agorophobia
Both (1) and (2): recurrent unexpected Panic Attacks at least one of the attacks has been followed by 1 month (or more) of one (or more) of the following: persistent concern about having additional attacks worry about the implications of the attack or its consequences (e.g., losing control, having a heart attack, “going crazy”) a significant change in behavior related to the attacks

Criteria for Panic Disorder Without or With Agorophobia
Absence of Agoraphobia(For diagnosis of Panic Disorder Without Agorophobia) , Presence of Agoraphobia (For diagnosis of Panic Disorder With Agorophobia) . The Panic Attacks are not due to the direct physiological effects of a substance (drug of abuse, a medication) or a general medical condition (e.g., hyperthyroidism). The Panic Attacks are not better accounted for by another mental disorder, such as Social Phobia (e.g., occurring on exposure to feared social situations), Specific Phobia (e.g., occurring on exposure to a specific phobic situation), Obsessive-Compulsive Disorder (e.g., on exposure to dirt in someone with an obsession about contamination), Posttraumatic Stress Disorder (e.g., on exposure to stimuli associated with a severe stressor), or Separation Anxiety Disorder (e.g., on response to being away from home or close relatives).

Criteria for Agorophobia Without History of Panic Disorder
The presence of Agoraphobia related to fear of developing panic-like symptoms (e.g., dizziness or diarrhea). Criteria have never been met for Panic disorder. The disturbance is not due to the direct physiological effect of a substance (e.g., a drug of abuse, a medication) or a general medical condition. If an associated general medical condition is present, the fear described in Criterion A is clearly in excess of that usually associated with the condition.

Criteria for Specific Phobia
Marked and persistent fear that is excessive or unreasonable, cued by the presence or anticipation of a specific object or situation (e.g., flying, heights, animals, receiving an injection, seeing blood). Exposure to the phobic stimulus almost invariably provokes an immediate anxiety response, which may take the form of a situationally bound or situationally predisposed Panic Attack. Note: In children, the anxiety may be expressed by crying, tantrums, freezing, or clinging.

The person recognizes that the fear is excessive or unreasonable. Note: In children, this feature may be absent. The phobic situation(s) is avoided or else is endured with intense anxiety or distress. The avoidance, anxious anticipation, or distress in the feared situation(s) interferes significantly with the person's normal routine, occupational (or academic) functioning or social activities or relationships, or there is marked distress about having the phobia. In individuals under the age of 18 years, the duration is at least 6 months.

The anxiety, Panic Attacks, or phobic avoidance associated with the specific object or situation are not better accounted for by another mental disorder, such as Obsessive-Compulsive Disorder (e.g., fear of dirt in someone with an obsession about contamination), Posttraumatic Stress Disorder (e.g., avoidance of stimuli associated with a severe stressor), Separation Anxiety Disorder (e.g., avoidance of school), Social Phobia (e.g., avoidance of social situations because of fear of embarrassment), Panic Disorder With Agoraphobia, or Agoraphobia Without History of Panic Disorder

Specify type Animal Type Natural Environment Type (e.g. heights, storms, water) Blood Injection-Injury Type Situational Type (e.g., airplanes, elevators, enclosed places) Other Type (e.g. phobic avoidance of situations that may lead to choking, vomiting, or contracting an illness; in children, avoidance of loud sounds or costumed characters)

Criteria for Social Phobia
A marked or persistent fear of one or more social or performance situations in which the person is exposed to unfamiliar people or to possible scrutiny by others. The individual fears that he or she will act in a way (or show anxiety symptoms) that will be humiliating or embarrassing. Note: In children, there must be evidence of the capacity for age-appropriate social relationships with familiar people and the anxiety must occur in peer settings, not just in interactions with adults. Exposure to the feared social situation almost invariably provokes anxiety, which may take the form of a situationally bound or situationally predisposed Panic Attack. Note: In children, the anxiety may be expressed by crying, tantrums, freezing, or shrinking from social situations with unfamiliar people.

The person recognizes that the fear is excessive or unreasonable. Note: In children, this feature may be absent. The feared social or performance situations are avoided or else are endured with intense anxiety or distress. The avoidance, anxious anticipation, or distress in the feared social or performance situation(s) interferes significantly with the person's normal routine, occupational (academic) functioning, or social activities or relationships, or there is marked distress about having the phobia. In individuals under age 18 years, the duration is at least 6 months.

The fear or avoidance is not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication) or a general medical condition and is not better accounted for by another mental disorder (e.g., Panic Disorder With or Without Agoraphobia, Separation Anxiety Disorder, Body Dysmorphic Disorder, a Pervasive Developmental Disorder, or Schizoid Personality Disorder) If a general medical condition or another mental disorder is present, the fear in Criterion A is unrelated to it, e.g., the fear is not of Stuttering, trembling in Parkinson's disease, or exhibiting abnormal eating behavior in Anorexia Nervosa or Bulimia Nervosa. Specify if Generalized: If the fears include most social situations (also consider the additional diagnosis of Avoidant Personality Disorder)

Criteria for Obsessive-Compulsive Disorder
Either obsessions or compulsions: Obsessions are defined by (1), (2), (3), and (4): recurrent and persistent thoughts, impulses, or images that are experienced at some time during the disturbance, as intrusive and inappropriate and that cause marked anxiety or distress the thoughts, impulses, or images are not simply excessive worries about real-life problems the person attempts to ignore or suppress such thoughts, impulses, or images, or to neutralize them with some other thought or action the person recognizes that the obsessional thoughts, impulses, or images are a product of his or her own mind (not imposed from without as in thought insertion)

Either obsessions or compulsions: B. Compulsions are defined by (1) and (2): repetitive behaviors (e.g., hand washing, ordering, checking) or mental acts (e.g., praying, counting, repeating words silently) that the person feels driven to perform in response to an obsession, or according to rules that must be applied rigidly the behaviors or mental acts are aimed at preventing or reducing distress or preventing some dreaded event or situation; however, these behaviors or mental acts either are not connected in a realistic way with what they are designed to neutralize or prevent or are clearly excessive

At some point during the course of the disorder, the person has recognized that the obsessions or compulsions are excessive or unreasonable. Note: This does not apply to children. The obsessions or compulsions cause marked distress, are time consuming (take more than 1 hour a day), or significantly interfere with the person's normal routine, occupational (or academic) functioning, or usual social activities or relationships.

D - If another Axis I disorder is present, the content of the obsessions or compulsions is not restricted to it (e.g., preoccupation with food in the presence of an Eating Disorder; hair pulling in the presence of Trichotillomania; concern with appearance in the presence of Body Dysmorphic Disorder; preoccupation with drugs in the presence of a Substance Use Disorder; preoccupation with having a serious illness in the presence of Hypochondriasis; preoccupation with sexual urges or fantasies in the presence of a Paraphilia; or guilty ruminations in the presence of Major Depressive Disorder). E - The disturbance is not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication) or a general medical condition. Specify if: With poor insight: If, for most of the time during the current episode, the person does not recognize that the obsessions and compulsions are excessive or unreasonable.

Specify if: With poor insight: If, for most of the time during the current episode, the person does not recognize that the obsessions and compulsions are excessive or unreasonable.

Criteria for Posttraumatic Stress Disorder
The person has been exposed to a traumatic event in which both of the following were present: the person experienced, witnessed, or was confronted with an event that involved actual or threatened death or serious injury, or a threat to the physical integrity of self or others the person's response involved intense fear, helplessness, or horror. Note: In children this may be expressed instead by disorganized or agitated behavior

The traumatic event is persistently re-experienced in one (or more) of the following ways: recurrent and intrusive distressing recollections of the event, including images, thoughts, or perceptions. Note: In young children, repetitive play may occur in which themes or aspects of the trauma are expressed. recurrent distressing dreams of the event. Note: In children, there may be frightening dreams without recognizable content. acting or feeling as if the traumatic event were recurring (includes a sense of reliving the experience, illusions, hallucinations, and dissociative flashback episodes, including those that occur on awakening or when intoxicated). Note: In young children, trauma-specific re-enactment may occur. intense psychological distress at exposure to internal or external cues that symbolize or resemble an aspect of the traumatic event physiological reactivity on exposure to internal or external cues that symbolize or resemble an aspect of the traumatic event.

Persistent avoidance of stimuli associated with the trauma and numbing of general responsiveness (not present before the trauma), as indicated by three (or more) of the following: efforts to avoid thoughts, feelings, or conversations associated with the trauma efforts to avoid activities, places, or people that arouse recollections of the trauma inability to recall an important aspect of the trauma markedly diminished interest or participation in significant activities feeling of detachment or estrangement from others restricted range of affect (e.g., unable to have loving feelings) sense of a foreshortened future (e.g., does not expect to have a career, marriage, children, or a normal life span)

Persistent symptoms of increased arousal (not present before the trauma), as indicated by two (or more) of the following: difficulty falling or staying asleep irritability or outbursts of anger difficulty concentrating hypervigilance exaggerated startle response Duration of the disturbance (symptoms in Criteria B, C, and D) is more than 1 month. The disturbance causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

Specify if: Acute: If duration of symptoms is less than 3 months Chronic: If duration of symptoms is 3 months or more Specify if: With delayed onset: If onset of symptoms is at least 6 months after the stressor

Criteria for Acute Stress Disorder
The person has been exposed to a traumatic event in which both of the following were present: the person experienced, witnessed, or was confronted with an event that involved actual or threatened death or serious injury, or a threat to the physical integrity of self or others the person's response involved intense fear, helplessness, or horror

Either while experiencing or after experiencing the distressing event, the individual has three (or more) of the following dissociative symptoms: A subjective sense of numbing, detachment, or absence of emotional responsiveness a reduction in awareness of his or her surroundings (e.g., “being in a daze”) derealization depersonalization dissociative amnesia (i.e., inability to recall an important aspect of the trauma)

The traumatic event is persistently reexperienced in at least one of the following ways: recurrent images, thoughts, dreams, illusions, flashback episodes, or a sense of reliving the experience; or distress on exposure to reminders of the traumatic event. Marked avoidance of stimuli that arouse recollections of the trauma (e.g., thoughts, feelings, conversations, activities, places, people). Marked symptoms of anxiety or increased arousal (e.g., difficulty sleeping, irritability, poor concentration, hypervigilance, exaggerated startle response, motor restlessness).

The disturbance causes clinically significant distress or impairment in social, occupational, or other important areas of functioning or impairs the individual's ability to pursue some necessary task, such as obtaining necessary assistance or mobilizing personal resources by telling family members about the traumatic experience. The disturbance lasts for a minimum of 2 days and a maximum of 4 weeks and occurs within 4 weeks of the traumatic event. The disturbance is not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication) or a general medical condition, is not better accounted for by Brief Psychotic Disorder, and is not merely an exacerbation of a preexisting Axis I or Axis II disorder.

Criteria for Generalized Anxiety Disorder
Excessive anxiety and worry (apprehensive expectation), occurring more days than not for at least 6 months, about a number of events or activities (such as work or school performance). The person finds it difficult to control the worry.

The anxiety and worry are associated with three (or more) of the following six symptoms (with at least some symptoms present for more days than not for the past 6 months). Note: Only one item is required in children. restlessness or feeling keyed up or on edge being easily fatigued difficulty concentrating irritability muscle tension sleep disturbance (difficulty falling or staying asleep, or restless unsatisfying sleep)

The focus of the anxiety and worry is not confined to features of an Axis I disorder, e.g., the anxiety or worry is not about having a Panic Attack (as in Panic Disorder), being embarrassed in public (as in Social Phobia), being contaminated (as in Obsessive-Compulsive Disorder), being away from home (as in Separation Anxiety Disorder), gaining weight (as in Anorexia Nervosa), having multiple physical complaints (as in Somatization Disorder), or having a serious illness (as in Hypochondriasis), and the anxiety or worry do not occur exclusively during Posttraumatic Stress Disorder. The anxiety, worry, or physical symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. The disturbance is not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication) or a general medical condition (e.g., hypothyroidism) and does not occur exclusively during a Mood Disorder, a Psychotic Disorder, or a Pervasive Developmental Disorder.

Treatment Pharmacotherapy Psychotherapy

Pharmacotherapy Medications for Anxiety in Predictable Situations
β-Adrenergic Receptor Antagonists Benzodiazepines

Medications for Chronic Recurrent or Unpredictable Anxiety
Selective Serotonin Reuptake Inhibitors DUAL (SEROTONIN–NOREPINEPHRINE) REUPTAKE INHIBITORS Tricyclic and Heterocyclic Antidepressants Monoamine Oxidase Inhibitors Mirtazapine Bupropion Benzodiazepines Antipsychotics Buspirone

Psychotherapy Cognitive–Behavioral Therapy

Anxiety Disorders: Introduction

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