1. NA-MIC National Alliance for Medical Image Computing http://na-mic.org Informatics tools & services for NA-MIC Dan Marcus Neuroinformatics Research Group Washington University

2. National Alliance for Medical Image Computing http://na-mic.org Overview 1.Introduction to the Neuroinformatics Research Group (NRG) 2.Introduction to XNAT 3.New XNAT features 4.XNAT and NA-MIC Kit 5.XNAT Central and DBPs

3. National Alliance for Medical Image Computing http://na-mic.org Introduction to NRG NRG  Neuroimaging Laboratories  Mallinckrodt Institute of Radiology  Washington University School of Medicine Neuroinformatics software (XNAT is our flagship product) Data & analysis centers (ADRC, BIRN, Brainscape, XNAT Central, etc.) http://nrg.wustl.edu

4. National Alliance for Medical Image Computing http://na-mic.org Introduction to NRG Mohana Ramaratnam, Dan Marcus, Tim Olsen, Kevin Archie, Misha Milchenko (not pictured)

5. National Alliance for Medical Image Computing http://na-mic.org Introduction to XNAT Informatics platform for managing biomedical imaging & related data File repository for image data Relational database for metadata and non-image measures User interface tools Auxiliary services (e.g. DICOM, FTP) http://www.xnat.org

6. National Alliance for Medical Image Computing http://na-mic.org Introduction to XNAT XNAT 1.3 available at www.xnat.org XNAT 1.4 beta available from CVS repository at http://nrg.wustl.edu/viewvc (install instructions posted to google group http://groups.google.com/group/xnat_discussion). XNAT 1.4 production scheduled for March release XNAT 2.0 in conceptual stage

7. National Alliance for Medical Image Computing http://na-mic.org Example XNAT deployments www.brainscape.orgcentral.xnat.org

8. National Alliance for Medical Image Computing http://na-mic.org Project orientation

9. National Alliance for Medical Image Computing http://na-mic.org Improved upload & download

10. National Alliance for Medical Image Computing http://na-mic.org Improved pipeline services

11. National Alliance for Medical Image Computing http://na-mic.org Improved user interface

12. National Alliance for Medical Image Computing http://na-mic.org User-defined study measures

13. National Alliance for Medical Image Computing http://na-mic.org XNAT and NA-MIC Kit NA-MIC needs: Improved management of ‘local’ image data Integration with Slicer and Batchmake Data sharing with collaborators

14. National Alliance for Medical Image Computing http://na-mic.org XNAT and NA-MIC Kit XNAT solution: Desktop XNAT that delivers basic XNAT functionality Push and pull data from ‘central’ XNAT repositories via web services Integration with Slicer and Batchmake via XCEDE XML Data sharing via lightweight web services

15. National Alliance for Medical Image Computing http://na-mic.org XNAT and NA-MIC Kit Osirix Local database Integration with viewer & processing

16. National Alliance for Medical Image Computing http://na-mic.org XNAT and NA-MIC Kit Flickr Tags Sets API

17. National Alliance for Medical Image Computing http://na-mic.org XNAT Central & NA-MIC DBPs Reference data Data from studies in pub. database Collaboration data Personal data

18. National Alliance for Medical Image Computing http://na-mic.org XNAT/NA-MIC bliss Please seek us out for discussion!

19. National Alliance for Medical Image Computing http://na-mic.org

20. Recap of MGH contributions QDEC: GUI for group analysis of Freesurfer-processed subject data Combined volumetric and surface (CVS) registration

21. National Alliance for Medical Image Computing http://na-mic.org QDEC GUI for group analysis http://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/QdecGroupAnalysis “Does the correlation between cortical thickness and age differ from zero?”

22. National Alliance for Medical Image Computing http://na-mic.org CVS registration Surface-based (2D) registration aligns cortical folds, but doesn’t apply to non- cortical structures. Volumetric (3D) registration applies to the entire brain but doesn’t align cortical folds. Solution: integrate them! Template FLIRT HAMMER CVS

23. National Alliance for Medical Image Computing http://na-mic.org XNAT 1.x: Three tiers Engine Database Clients

24. National Alliance for Medical Image Computing http://na-mic.org XNAT 1.x: Three tiers Engine Database ClientsWeb application

25. National Alliance for Medical Image Computing http://na-mic.org XNAT 1.x: Three tiers Engine Database Clients Web application

26. National Alliance for Medical Image Computing http://na-mic.org XNAT 2.0: Service orientation XNAT Services Meta- data PipelineFileTagsSecurity

27. National Alliance for Medical Image Computing http://na-mic.org XNAT 2.0: Service orientation XNAT Services Meta- data PipelineFileTagsSecurity

28. National Alliance for Medical Image Computing http://na-mic.org XNAT 2.0: Service orientation XNAT Services Meta- data PipelineFileTagsSecurity XNAT Applications WebDesktop Cmd. line

29. National Alliance for Medical Image Computing http://na-mic.org XNAT 2.0: Service orientation XNAT Services Meta- data PipelineFileTagsSecurity XNAT Applications WebDesktop Cmd. line Non-XNAT Apps

30. National Alliance for Medical Image Computing http://na-mic.org Advantages of SOA Componentized Deployment flexibility Agility Better interoperability Federation