1. 1 Prediabetes Burden

2. 2 Epidemiology: Health Performance Gaps Prevalence Risk factors –Metabolic syndrome –Obesity Clinical risks of prediabetes –Progression to diabetes Complications (eg, retinopathy)

3. 3 Impaired Glucose Tolerance Impaired Fasting Glucose Diabetes Progression to Type 2 Diabetes Or both Prediabetes

4. 4 Prevalence of Diabetes and Prediabetes in the United States CDC and Prevention. National diabetes fact sheet, 2007. http://www.cdc.gov/Diabetes/pubs/pdf/ndfs_2007.pdf. CDC and Prevention. National diabetes fact sheet, 2011. http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf. Prediabetes 35% of US population Diabetes 8.3% of US population Persons (millions) 39% increase Increased incidence of prediabetes from 2007 to 2010

5. 5 Incidence of prediabetes, IFG, and IGT in a representative sample of the US population Prevalence of IFG and IGT in US Adults Without T2DM: NHANES Data IFG, impaired fasting glucose; IGT, impaired glucose tolerance; NHANES, National Health and Nutrition Examination Survey ; T2DM, type 2 diabetes mellitus. Karve A, Hayward RA. Diabetes Care. 2010;33:2355-2359.

6. 6 How Much Does the Metabolic Syndrome Raise the Risk of T2DM? IFG, impaired fasting glucose; MetSyn, metabolic syndrome; T2DM, type 2 diabetes mellitus. Lorenzo C, et al. Diabetes Care. 2007;30:8-13. 1.0 5.0 10.0 20.0 25.0 MetSyn without IFG without MetSyn + IFG No MetSyn No IFG Odds Ratio (Confidence Interval) 5.03 (3.39-7.48) 21.0 (13.1-33.8) 7.07 (3.32-15.1) 1.0 (ref) T2DM risk, stratified by IFG and metabolic syndrome