1. Dr Motlalepula G. Matsabisa
Indigenous Knowledge Systems [Health]
Medical Research Council – South Africa
Portfolio Committee on Health
April 11th 2004

2. Our Mission and Vision
To promote and advance indigenous knowledge systems through research and development by making it a valued health model in the global environment and to redress health traditions, which until now have neglected health research priorities and issues.
To be a centre of excellence in traditional medicines research regionally and to be competitive globally

3. Objectives
Coordination and development of health research in indigenous knowledge
Institutional and community networks
Development of an enabling clinical trial environment
Innovations and commercialization in traditional health systems.
Policies governing intellectual property and benefit-sharing
Research programmes that are appropriate & relevant
Support academic research
Funding

4. CEO Interim: Prof AD Mbewu Director Dr MG Matsabisa
Research Directorate
IKS Lead Programme
Director Dr MG Matsabisa
IKS Knowledge
Management
IKS Research and
Development
IKS Utilization
SBU
IKS Laboratory
IKS Resource Centre
IKS Production Facility & Quality Control Laboratory
DELFT: MRC’s Core IKS Facilities
Drug Discovery
Clinical Trials
Toxicity
New Research Methodologies
Databases
National Reference Centre
Health Promotion
Policy
Advocacy
Healer Liaison
Poverty Eradication Programmes
Pilot Farms
Horticulture
Production GMP

5. IKS Research and Development IKS Knowledge Management
Current Projects
IKS Research and Development
IKS Knowledge Management
IKS Utilization (SBU)
Research
Policy
Database
Special Projects
DELFT CENTRE
MALARIA
IK TRUST
TRAMED III
ACCESS & BENEFIT-SHARING
Medicinal Garden Project
Training Programme
HYPERTENSION
HIV AND AIDS
School outreach program
IKS RESEARCH GUIDELINES
NHKN
CLINICAL TRIALS PLATFORM
TUBERCULOSIS
IP POLICY
TRADITIONAL HEALERS
FARM
CANCER
MCC - ATMC
TDr Program
PAIN
MONONGRAPHS
NATIONAL REFERENCE CENTRE for ATM
DIABETES
POVERTY ALLIVIATION
TRADITIONAL HEALTH CLAIMS
TOXICOLOGY

6. Agreements Traditional Immune Boosters Antihypertensive
Signed between TDr, Individuals and MRC on Collaborative Research
Traditional Immune Boosters Antihypertensive
- Eastern Cape (2) North West
- North West
- KwaZulu/Natal
- Gauteng (3)
- Limpopo
Traditional Cure for Breast Cancer Anti -Tuberculosis
- Gauteng North West
- Gauteng
Traditional Antidiarhoeal
Traditional Antimalarial International agreements:
- Free State, KwaZulu/Natal Tanzania – Immune modulator & Antidiabetic
- Uganda – Antidiabetic, antihypertensive
Traditional Antidiabetic Nigeria – University of Ibadan
- Eastern Cape US – Rutgers University N.J - Antimalarial
- Kenya – KEMRI - KETRI
- Botswana – UB, Chemistry, & BOTEC

7. Malaria
Preclinical studies
Clinical studies

8. C30H28O6
C30H28O7

9. Antimalarial activity

10. Resistance Modulators
Cancer
Antibiotics
Malaria
HIV and AIDS

11. Anticancer

12. Antidiabetic

13. HIV and AIDS Assessment of Traditional Claims for cures
Safety, Efficacy studies
Value addition

14. Clinical Trials Ethics Toxicology Clinical Human Trials
Ethics: Informed consent for screening
Informed consent for HIV testing
Informed consent for participation in the study
Information leaflet for the screening
Information leaflet for participation in the study
Counseling:
Integrated approach: To whole family
Pre-screening HIV counseling
1 post screening counseling (referral of those that are HIV+, but not meeting the inclusion criteria to appropriate & accredited centres for support)
Ethical approval: (scientific and ethical merits)
Protocols are peer-reviewed
Submitted to MRC & MCC’s Clinical Trials Committee (CTC) for ethical evaluation
Toxicology
90-day sub chronic study on a non-human primate model
Clinical Human Trials
Both Phase I and II/III
Are double blind, randomized, placebo controlled dose elevation parallel group studies

15. Case Studies
Extract A SO %
Extract B PT %
Extract C Cm & g %

16. HIV and AIDS Training School Outreach Community Partnership
Medicinal Herb Garden

17. MRC Delft Community Project
Provide enabling environment for healers and scientists to interact
Formal structure for healers to interact, develop policy and develop communication products
Provide healers access to scientific infrastructure (Information, Library, Internet access, database, medicinal plant cultivation, drug discovery, Resource Centre)
Provide a forum for structured health education and promotion (Herb garden)
Develop skills in growing, processing, packaging and marketing of herbal products

19. School out-reach Program and TDr Training Program
[photos not included]

21. IKS Utilization Strategic Business Unit Socio-economic Development
Poverty Elimination
Manufacturing

22. Poverty Elimination

23. Organizational Structure
DST
Health Education
Agriculture
MRC
Skills transfer
Skills transfer
Entrepreneurial skills development
Community
Commercial Partner
Municipality
Skills transfer
Business development
Infrastructure
Land
Markets
Nursery
Commercial farming

24. Methodology THE VALUE ADDED CHAIN
Creation (Patents, Innovations)
Knowledge
Point of entry Existing Industries Services
_________________________________________________
Industries
Point of entry Emerging Industries
Agriculture

25. Entrepreneurial viability
Theoretical model
MARKET
Commercial viability
(2)
INSTITITONAL
SUPPORT
(1)
MRC
Municipalities
Private sector
INDUSTRY
(5)
Partnerships
Technical viability
(3)
Entrepreneurial viability
(4)

26. Kimberley Place: Sterkspruit Municipality: Senqu
Municipality: Tsolwana
Place: Hofmeyer/ Tarkastad

27. Anticipated Impact Job creation Sustainable use of medicinal plants
Application of scientific research developed by the IKS Lead Programme
Capacity building for institutions (municipalities)
Training and promotion of the culture of entrepreneurship
The promotion of registered business ventures fully owned by emerging entrepreneurs
Horizontal and vertical integration of the area surrounding the projects.

28. IKS Technologies Systems – Mechanisms of Action Analytical analysis
Quality Control
Manufacturing
Proteomics
Genomics
Metabolimics
Cytochrome P540
1a2 2a
2c19
2d6
2c8
2c9
2e1
3a4

29. International Collaboration
Tanzania – Immune modulator & Antidiabetic
Uganda – Antidiabetic, antihypertensive
Nigeria – University of Ibadan
US – Rutgers University N.J - Antimalarial
Kenya – KEMRI – KETRI
Botswana – UB, Chemistry & BOTEC
Lesotho Ministry of Health
USHEPiA – University Science, Humanities, Engineering Partnerships in Africa
African Initiative on Traditional Medicines against Malaria, HIV and AIDS, TB and other Diseases

30. Conclusion
To support the mission and vision of MRC and support National Programmes on Health, science and Technology
Seek increased baseline support from MRC if IKS is to make and impact
– seek a baseline funding of R2 million per year
- Requesting R2,5 million for infrastructural development at
Delft ( Match up R4 million from DST for equipment)
Increase the science staff complement in IKS
To get science to benefit our communities
To develop and manage partnerships and consortia effectively (African Initiative on Traditional Medicines, Indian Traditional Medicines, WHO Afro scientific advisory committee)
To be a centre of excellence in Traditional Medicines research
Capacitated GP (clinical trials), Traditional healers (Training, knowledge transfer, IP, Commercialization), Communities (poverty reduction, business skills, community enterprises), Scientists (State of the art equipment and research)
Empowerment (CPPP), Business development, BEE, spin out companies

31. How to Contact Us Indigenous Knowledge Systems [Health] Lead Programme
Dr MG Matsabisa – Director
Tel
Fax .
Website:
“Going back to our roots for innovative health solutions”