1. Non-Specific Immune Response How Cells recognise each other. The role of Inflammation Phagocytosis Cell response to Viruses Key Terms: Antigens, Histamine, Mast Cells, Oedema, Fever, Phagocytosis, Granulocytes, Agranulocytes, Interferons

2. The immune response

3. Cell Recognition Peripheral proteins on the extracellular side of the membrane act as receptors for hormones or neurotransmitters, or are involved in cell recognition. Many are glycoproteins.

4. Non-specific immune response The non-specific or innate immune response quickly targets a wide range of pathogens and foreign substances. Phagocytosis, inflammation and the antimicrobial proteins lysozyme and interferons are all part of this immune response. Lysozyme is an enzyme that disrupts the cell walls of gram- positive bacteria by digesting the peptidoglycan. It is found in human tears, saliva and lysosomes. Interferons are proteins produced by virus-infected body cells in response to the virus. Interferons trigger the production of a second protein that inhibits viral replication by binding to mRNA coded by the virus.

5. What happens during Inflammation & Phagocytosis?

6. Phagocytosis

7. Phagocytosis Animations McGraw-Hill http://www.youtube.com/watch?v=7VQU28it VVw http://www.youtube.com/watch?v=7VQU28it VVw A Musical Interpretation! http://www.youtube.com/watch?v=VAhM9Ox ZDkU http://www.youtube.com/watch?v=VAhM9Ox ZDkU

8. Activities 1)Read and highlight both sides of the information sheet and add detail to your notes on Inflammation and Phagocytosis. 2)Use this and pages 97 -99 in your textbook to work through the activities on: ‘Phagocytosis & other Non-Specific Responses’

9. Non-specific immunity: true or false?