1. 12 Tectonic Plates Shaping the Formation of Regional STEMI Networks Ivan C. Rokos, MD, FACEP, (FACC) Emergency Physician Asst. Clinical Professor, UCLA Staff Physician, Olive View-UCLA Staff Physician, Northridge Hospital Los Angeles, CA

2. Disclosures No financial disclosure Member –ACC D2B Alliance Steering Committee –AHA Mission: Lifeline Emergency Cardiac Care Committee Model Evaluation Committee –AHA California STEMI Task Force –LA County STEMI Receiving Center Network planning –Volunteer consultant to the E2B Coalition www.E2Bchallenge.com

3. Primary Objective ACC vision  Quality and Value –Guidelines, Registries, Appropriate Use Criteria –Dr. Weaver, President’s Page, JACC, March 10, 2009 Systems and Networks allow frontline clinicians to consistently achieve Quality In an organized system…. –Good clinicians excel –Average providers still do the right thing –Fix “bad systems,” not “bad clinicians”

4. Large and Powerful Tectonic Plates shape our planet’s geography 12 Tectonic Plates are shaping the formation of STEMI Networks

5. Tectonic Plates #1-4 National Trauma Center Systems –Example of multi-disciplinary collaboration NRMI Registry –The Status quo for D2B was slow Feds and Core Measures –Mandated Transparency Institute of Medicine 2006 Report –Emergency Care at the Breaking Point

6. Tectonic Plates #5-8 ACC/AHA STEMI Guidelines –2004 Benchmark of D2B ≤90 Minutes ACC D2B Alliance –Improve INTRA-hospital process for PPCI Two European Studies –Prague-2 and Danami-2 Technology –Automated pre-hospital ECGs and Defibrillators

7. #9) “Grassroots” Initiative (Rokos IC, 2006 AHJ,152:661) Multi-Disciplinary Influenced by the 8 prior Tectonic Plates Inter-hospital transfer & pre-hospital cardiac triage

8. “Grassroots” intersects with Big Society 11 Papers, Circulation May 30, 2007

9. Inter-hospital Transfer in 2007 Minneapolis (Henry et al, Circulation 07) Mayo Rochester (Ting et al, Circulation 07) North Carolina RACE (Jollis et al, JAMA 07)

10. Pre-hospital Cardiac Triage Regional diversion protocol allowing EMS to transport STEMI directly to PPCI-capable hospitals Cardiac cath lab accessible 24/7/365 regardless of ED-diversion status Parallel processing  patient transport and cardiac cath lab activation occurring simultaneously Plan A = PCI, Plan B = Fibrinolytics Regional Quality Improvement Database

11. “Clever” Devices need Networks & Systems

12. 45 STEMI Receiving Centers: Ventura, Los Angeles, & Orange Counties (California) 64 in So. Cal : 19 more SRCs San Diego, Riverside, San Bernadino Counties.

13. The DATA

14. JACC CV Interventions, April 2009, in press

15. Map of 10 STEMI Networks (Rokos et al, 2009 JACC Intv., in press) PDF

16. Demographic Summary for 10-regions 20+ million citizens 5,000+ paramedics 166 hospitals  Paramedic Receiving Centers –72 hospitals  STEMI Receiving Centers D2B Data spans: –Unique start date for each region –End August 31, 2007 –Includes ALL consecutive patients

17. Study Population Aggregate 10-region Data 2,712 PH-ECG(+) for presumed STEMI –N= 659 (24%) PH-ECG(+) but PPCI(-) –N=2,053 (76%) PH-ECG(+) and PPCI(+)

18. D2B Pooled Analysis N = 2,053 for 10 SRC networks combined 86% rate of D2B  90 Minutes Inclusions: –ALL consecutive PH-ECG (+) and PPCI (+) Exclusions: –No self-transport patients –No inter-hospital transfer patients

19. Rate of D2B ≤ 90min by Region (Rokos et al, 2009 JACC Intv., in press) Solid Red line represents the Primary Endpoint. Dashed Red line is D2B Alliance Benchmark N = 2,053

20. Secondary Endpoints: N=2,053 with D2B Time 50% rate of D2B ≤ 60 Minutes (N=1,031) 25% rate of D2B ≤ 45 Minutes (N=517) 8% rate of D2B ≤ 30 Minutes (N=155)

21. CathPCI Registry 2005-06 (N=43,801) (Rathore et al, Circulation, AHA08 abstract #6174)  D2B from 90 to 60 minutes associated with  0.8% Mortality  D2B from 60 to 30 minutes associated with  0.5% Mortality In-hospital Mortality

22. E2B  EMS-to-Balloon time EMS = Emergency Medical Services Time Zero = Date and Time auto-stamped on first PH-ECG diagnostic of STEMI

23. Tertiary Endpoint (EMS)-to-Balloon (E2B) 2,053 were PH-ECG(+) and PPCI(+) 762 of 2,053 (37%) had PH-ECG time recorded in a database (5 regions: LAC, MSP, Med, Cha, Ven) –68% rate of E2B ≤ 90 minutes

24. Primary Objective Systems and Networks provide your community with Quality 9-1-1 is A2Q Access to Quality (Tectonic Plate #9)

25. #10) National Registries ACC/AHA Collaboration NCDR created and empowered a large, enthusiastic workforce of QI personnel across most PPCI hospitals

26. #11) AHA Mission: Lifeline National community-based initiative The “ideal” becomes the “routine” Goals: –Improve quality of care & outcomes in STEMI –Improve health care system readiness and response

27. Developing Ideal STEMI Systems 27

28. Secondary Objective: How do ACC-D2B and AHA-MLL interact?

29. Developing Ideal STEMI Systems 29

30. STEMI Systems Synergy Collaborating Societies & Organizations AHA Mission: Lifeline  Inter-Hospital, Pre-hospital, Patient Education pre/post (N=5,000) ACC D2B Alliance  Intra-hospital (N=1200) Registries  Guideline-based Performance Measures and Quality Metrics

31. Tectonic Plate #12 Bigger than ACC, AHA, NCDR, TJC, etc.

32. #12) Change …. You Can Believe In Obama Campaign website –“I am asking you to Believe…not just in my ability to bring about real change in Washington…I’m asking you to Believe in yours “STEMI Activist” –Ordinary healthcare professionals trying to optimize the STEMI system in their region using best evidence –Empowerment & Engagement  Sustainability

33. Summary Three Objectives To achieve Quality and Value… –Organize Systems and Networks –Patient-centered care is Priority #1 (ACC/AHA) Synergy clearly exists between… –ACC D2B Alliance –AHA Mission: Lifeline Spread the spirit of STEMI Activism –State STEMI Contact List Email: irokos@earthlink.net