Download presentation
Presentation is loading. Please wait.
Published byBryan Freeman Modified over 9 years ago
9
Fertilization a process at the beginning of ourselves
10
Sperm A human sperm. Egg Overview The zona pellucida.The zona pellucida Structure of Sperm and Egg
11
Scanning electron micrograph of a human sperm contacting a hamster egg. For detail For detail
12
Scanning electron micrograph of a clam egg with sperm bound to its surface. For detail
13
Block to polyspermy A depolarization of the egg plasma membrane a rapid, primary block to polyspermy Egg cortical reaction a slow, secondary block to polyspermy
14
primary block to polyspermy Na + influx triggered by fusing with sperm make the membrane potential of egg shift from –60mV to +20mV within a few second. Low concentration of Na + raise the incidence of polyspermy. Artificially depolarized an unfertilized egg prevent sperm from fusing with egg.
15
primary block to polyspermy It seems likely that the depolarization alter the conformation of a crucial protein in the egg plasma menbrane so that the sperm membrane can not fuse with the egg membrane. The egg membrane potencial returns to normal within a few minutes after fertilization.
16
a second mechanism must provide a long-term barrier to polyspermy. In most egg, including those of mammals, this barrier is provided by Cortical Reaction.BackBack Therefore
17
Second block to polyspermy When the sperm fuses with the egg plasma membrane, it activates the inositol phospholipid cell-signaling pathway in the egg. This, in turn, causes a local increase in cytosolic Ca 2+, which spreads through the cell in a wave. The rise in Ca 2+ activate the egg and initiate the cortical reaction.wave
18
Second block to polyspermy cortical granules located just under the plasma membrane of the egg release their contents by exocytosis. A,BAB The enzymes released by the cortical reaction change the structure of the zona pellucida, which becomes hardened so that sperm no longer bind to it, thereby providing a slow, secondary block to polyspermy. EndEnd
19
A mature Xenopus egg, ready for fertilization. For detailFor detail
20
The zona pellucida The zona pellucida. For detail For detail
21
A human sperm. It is shown in longitudinal section
22
Drawing of the midpiece of a mammalian sperm
23
Depolarization & Cortical reaction are the mechanics of Block to Polyspermy continue continue
32
Acrosome Reaction Sperm penetrate the zona pellucida by acrosome reaction. Process of acrosome reaction.Process of acrosome reaction Back
33
Process of Fertilization Acrosome reaction Deplarization Cortical Reaction 2nd oocyte complete Meiosis Ⅱ Pronucleus Replication of DNA in pronucleus First Mitosis
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.