1. Vitamin E
Dr.s.chakravarty md

2. Vitamin E:
Lipid soluble antioxidant in cell membranes and lipoproteins of plasma.
Tocopherols and Tocotrienols
Acts synergistically with Vit C and selenium (present in glutathione peroxidase) for reducing amount of free radical generation in membrane.
Most active form D-α Tocopherol .
Source – vegetable oils such as wheat germ oil, safflower and sunflower oils.

3. Antioxidant effect of Vit E, C and Se

4. Functions of Vit E: Stops the chain reaction of free radicals
Protection of polyunsaturated fatty acids and vitamin A
Protects the oxidation of LDLs – prevents atherosclerosis
But trials so far remain inconclusive .
Prevents hemolysis of RBCs
Used in hemolytic anaemia

5. Additional benefits:
Parkinson’s disease and Alzheimer disease – decreased free radical production
Nocturnal leg cramps and Intermittent claudication – decreased smooth muscle proliferation.
Retrolental fibroplasia and bronchopulmonary dysplasia – decreased free radical generation from 100% oxygen.

6. LESS vit E: Hemolytic anemia Increased risk of stroke and IHD
Spinocerebellar ataxia
Myopathy and neuropathy