1. Standards of Medical Care in Diabetes - 2008 Jeri Jennings Mills, RD/LD, CDE Sami Wood, RD/LD, CDE OSUMC Diabetes Education

2. Types of Diabetes Type 1 diabetes IDDM juvenile onset type I Type 2 diabetes NIDDM adult onset type II

3. Gestational diabetes (GDM) Others –Genetic defects in beta cell function –Genetic defects in insulin action –Diseases of the pancreas (cystic fibrosis) –Drug induced (AIDS Tx/organ transplantation) –MODY

4. Some patients cannot be clearly classified as type 1 or type 2 LADA Type 1.5

5. How to diagnosis diabetes FPG is the preferred diagnostic test Use of the A1c for diagnosis is not recommended at this time

6. Three diagnostic criteria: FPG > 125 mg/dL*, or “Casual” plasma glucose > 200 mg/dL & sx’s of high blood sugar, or 2-h plasma glucose* > 200 mg/dl (during an 75 gram glucose OGTT) *needs repeat confirmation on different day

7. Screening for diabetes In diabetes, the same tests used to screen for diabetes, also diagnose diabetes “There is no more ‘screening’ for type 2”!

8. Screening for type 1 diabetes Screening asymptomatic individuals for auto- antibodies is not currently recommended Clinical studies are being done to test various methods of preventing type 1

9. Joe is 30 years old with a BMI of 29. He does not exercise. His father has “borderline” diabetes. Joe has no symptoms of diabetes. Should he be tested? (B) 1.Yes 2.No

10. Testing for type 2 About 1/3 of all people with diabetes may be undiagnosed Average dx is 7-10 years after onset Type 2 DM is frequently diagnosed after complications appear So…who should be tested?

11. All adults with BMI >24 and a risk factor below… Physical inactivity 1 st degree relative with DM High-risk ethnic group Women w/hx GDM and/or PCOS HTN HDL 250 IGT or IFG on previous testing Acanthosis nigricans Hx of CVD Age 45 if none of the above apply & q 3 yrs…

14. “Type 2 diabetes has a long asymptomatic phase and significant clinical risk markers. Diabetes may be identified anywhere along a spectrum of clinical scenarios”.

15. Prediabetes is NOT “borderline diabetes”! Fasting: 100-125 – Impaired fasting glucose (IFG) 2-hr glucose: 140-199 – Impaired glucose tolerance (IGT) Both IFG and IGT are considered risk factors for future diabetes & CVD and should be treated.

16. Testing for type 2 diabetes in asymptomatic children (Table 4 page S14) BMI >85 th percentile for age & sex, weight for height or weight >120% of ideal for height plus 2 of the following risk factors…

17. Family hx in 1st or 2nd degree relative Race/ethnicity (African American, Native American, Latino, Asian, Pacific Islander) Signs of insulin resistance (Acanthosis nigricans, hypertension, dyslipidemia, or PCOS) Maternal history of diabetes or GDM

18. When to test for type 2 diabetes in children ( Table 4 page S14 ) Age of initiation: 10 yrs or at onset of puberty Frequency: every 2 yrs Test: FPG preferred

19. Gestational Diabetes (Table 5 Page S15) If high risk factors present, screen for diabetes ASAP after pregnancy confirmed. Marked obesity Hx of GDM Previous large-for-gestation-age infant Glycosuria PCOS or “insulin resistant” Fam Hx DM

20. Low risk factors for GDM Age <25 yrs Weight normal before pregnancy Member of ethnic group with low prevalence of diabetes No known diabetes in first degree relative No history of abnormal OGTT or GDM No history of poor obstetric outcome

21. Women with GDM should be tested for diabetes 6-12 weeks PP

22. Prevention/delay of type 2 diabetes after GDM Lifestyle modification counseling important Monitor for DM every 1-2 yrs Treat other CVD risk factors (tobacco use, HTN, dyslipidemia) Consider metformin in addition to lifestyle counseling

23. Reducing Diabetes Risk Lifestyle modification was shown to have the greatest effect in two well-controlled studies: Diabetes Prevention Program (DPP): reduced risk of developing diabetes by 58% Finnish Diabetes Prevention Study showed direct relationship between lifestyle intervention and decrease in diabetes

24. Self monitoring of blood glucose 2-4x/day if on insulin If on oral agents or MNT, SMBG is done to achieve glycemic control May include postprandial checks Routinely evaluate technique and patient’s ability to use data to adjust food intake, exercise, & medications.

25. An A1C should be tested at least once yearly. (E) 1.True 2.False

26. The A1C A “3 month average” should be checked at initial assessment - then regularly… 2x/year in patients meeting tx goals, quarterly in patients who are not meeting tx goals

27. The ADA A1C goal for nonpregnant adults with diabetes is <7%. (A) 1.True 2.False

28. ADA Glycemic Goals (Table 8, S18) A1c <7% (~ plasma glucose of 170 mg/dL) Pre-meal: 90-130 mg/dl Post-meal <180 (1-2 hrs post meal)

29. Glycemic control is fundamental to the management of diabetes UKPDS demonstrated significant reductions in microvascular and neuropathic complications with intensive therapy in type 2 DCCT demonstrated similar findings in type 1 diabetes

30. Relationship of A1C to Risk of Complications

31. Medical Nutrition Therapy (MNT) Individuals who have pre-diabetes or diabetes should receive individualized MNT to achieve treatment goals, preferably by a registered dietitian & certified diabetes educator (RD/CDE)

32. The ADA diabetic diet is the current recommendation for Medical NutritionTherapy (MNT). (A,E) 1.True 2.False

33. Hospital diets continue to be ordered by calorie levels based on the “ADA diet”. Since 1994, the ADA has not endorsed any single meal plan. The term “ADA diet” should no longer be used. I think that means it’s extinct!!

34. Physical Activity – Precautions EKG monitoring - should be considered before starting aerobic activity in the sedentary patient Autonomic Neuropathy – can decrease cardiac responsiveness in exercise. Is strongly associated with CVD in people with diabetes

35. Physical Activity (precautions) Dilated Eye Exam: resistance training is contraindicated if retinopathy is present (can trigger vitreous hemorrhage or retinal detachment) Foot Exam: Decreased pain sensation results in risk of skin breakdown, infection and of Charcot joint destruction. Consider non-weight bearing like swimming, bicycling, or arm exercises

36. Physical Activity (precautions) Hyperglycemia – in type 1 DM: Avoid exercise in presence of ketosis. Muscles can’t use sugar if not enough insulin available Hypoglycemia – Exercise increases insulin sensitivity. Low BS can result if pt on insulin or sulfonylurea drugs Check BS prior to exercise, during and after

37. Assessment of depression should be included in the medical management of diabetes. (E) 1.True 2.False

38. Psychosocial Assessment Depression is greater in individuals with diabetes –Can impact self-care behaviors –Screen for depression It is important to establish that emotional well-being is part of diabetes management.

39. Main Complications of Diabetes

41. Patients with type 2 DM should have a dilated eye exam within 5 years of diagnosis. (B) 1.True 2.False

42. Type 1 DM: dilated, comprehensive eye exam within 3-5 yrs of diagnosis, then yearly Type 2 DM: dilated, comprehensive eye exam shortly after diagnosis & then yearly Pregnant with pre-existing diabetes: eye exam in 1st trimester; f/u during pregnancy & for 1 year after

43. Individuals with diabetes should be started on statin therapy if they do not have CVD but are over age 40. (A) 1.True 2.False

44. Recommendations for those without CVD and under age 40 Trigs <150 HDL >40 in men HDL >50 in women LDL <100 –(consider statin therapy if LDL >100) LDL <70 in those with overt CVD

45. BP Goal <130 systolic/< 80 diastolic Consider daily aspirin (75-162 mg/day) –In people with diabetes between 30-40 years of age in presence of CV risk factors –Not recommended in anyone <21 yrs of age due to risk of Reye’s Syndrome

46. Smoking cessation counseling should be a treatment component of diabetes care. (B) 1.True 2.False

47. SMOKING Should be #1 intervention We have a smoking cessation counselor at OSUMC!!

48. In patients with type 2 DM, ACE’s and ARB’s have been shown to protect kidney function. (A) 1.True 2.False

49. Complications: Kidney ACE’s &/or ARB’s have been shown to delay nephropathy (contraindicated in pg) Screen annually for microalbuminuria: – in type 1 DM, diagnosed > 5 yrs, – in type 2 DM at diagnosis, and –during pregnancy Screen annually for serum creatinine & GFR

50. Complications: Kidneys Dietary protein reduction may be needed if CKD present Diabetic nephropathy is the single leading cause of ESRD (See Table 12 & 13 pg S30 for specific information)

51. A foot exam using a monofilament, tuning fork, palpation & visual exam should be done at least every 3 years. (B) 1.True 2.False

52. Diabetes Complications: FEET Foot Exam Should Be Done: –at diagnosis of type 2 –5 yrs after diagnosis of type 1 –at least annually thereafter

53. Diabetes Complications: FEET Includes use of monofilament, tuning fork, palpation and visual inspection Initial screening for PAD (Doppler Study or ABI – ankle brachial index)

54. Other Neuropathies: Autonomic diabetic neuropathy –Resting tachycardia –Exercise intolerance –Orthostatic hypotension –Constipation –Gastroparesis –Erectile dysfunction –Brittle diabetes –Hypoglycemic unawareness

55. Immunizations – Page S24 Flu vaccine annually >6 months of age w/DM At least one lifetime pneumococcal vaccine for adults with diabetes.

56. Diabetes Care: Inpatient Setting Glucose goals for critically ill: – 110 - <140 (A) Goals for non-critically ill: –fasting <126 and –random glucoses <180-200 (E)

57. Insulin in the Inpatient Setting “Sliding scale” or “correction scale” is NOT effective as monotherapy and is NOT recommended What is recommended? Meal-time coverage a “correction” scale, and basal insulin

58. Diabetes Self Management Education (DSME) People with diabetes need education from qualified health care providers with professional training (CDE’s) Should be reimbursed by 3 rd party payors Education should be on-going (yearly)

59. References You have been given an overview of your printed Diabetes Care article. Over 200 references to access for future lectures if needed Thank you for your time!