1. Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures by, Shunmugam Govender, Cristina Csimma, Harry K. Genant, Alexandre Valentin- Opran, Yehuda Amit, Ron Arbel, Hannu Aro, Dan Atar, Michael Bishay, Martin G. Börner, Philippe Chiron, Peter Choong, John Cinats, Brett Courtenay, Robert Feibel, Bernard Geulette, Charles Gravel, Norbert Haas, M. Raschke, Eric Hammacher, D. van der Velde, Philippe Hardy, Michael Holt, Christof Josten, Rupert Ludwig Ketterl, Bennie Lindeque, Günter Lob, Henry Mathevon, Gerald McCoy, D. Marsh, Russell Miller, Everard Munting, Stein Oevre, L. Nordsletten, Amratlal Patel, Anthony Pohl, William Rennie, Peter Reynders, Pol Maria Rommens, Jean Rondia, Willem C. Rossouw, P. J. Daneel, Stephen Ruff, Axel Rüter, Seppo Santavirta, Thomas A. Schildhauer, C. Gekle, Reinhard Schnettler, David Segal, Hanns Seiler, Robert B. Snowdowne, Jouwert Stapert, Gilbert Taglang, Rene Verdonk, Lucas Vogels, Arnulf Weckbach, Andreas Wentzensen, and Tadeusz Wisniewski J Bone Joint Surg Am Volume 84(12):2123-2134 December 1, 2002 ©2002 by The Journal of Bone and Joint Surgery, Inc.

2. Patients with secondary interventions in the treatment groups. n = number of intent-to-treat patients with a known outcome in each treatment group, SOC = standard-of-care (control) group, and rhBMP-2/ACS = groups treated with recombinant human bone morphoge... BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group, et al. J Bone Joint Surg Am 2002;84:2123- 2134 ©2002 by The Journal of Bone and Joint Surgery, Inc.

3. Proportions of secondary interventions according to the Gustilo-Anderson classification of wound severity. BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group, et al. J Bone Joint Surg Am 2002;84:2123- 2134 ©2002 by The Journal of Bone and Joint Surgery, Inc.

4. Proportions of secondary interventions according to smoking history. n = number of smokers or nonsmokers, SOC = standard-of-care (control) group, and rhBMP-2/ACS = groups treated with recombinant human bone morphogenetic protein-2 in an absorbable collagen... BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group, et al. J Bone Joint Surg Am 2002;84:2123- 2134 ©2002 by The Journal of Bone and Joint Surgery, Inc.

5. Success and failure in the treatment groups as determined by a combined clinical and radiographic end point. BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group, et al. J Bone Joint Surg Am 2002;84:2123- 2134 ©2002 by The Journal of Bone and Joint Surgery, Inc.

6. Anteroposterior radiographs of a twenty-nine-year-old man made at visits ranging from six to fifty weeks postoperatively. BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group, et al. J Bone Joint Surg Am 2002;84:2123- 2134 ©2002 by The Journal of Bone and Joint Surgery, Inc.

7. Rate of fracture-healing according to the treatment group and visit. BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group, et al. J Bone Joint Surg Am 2002;84:2123- 2134 ©2002 by The Journal of Bone and Joint Surgery, Inc.