1. Agilent 7500 ICP-MS
Date: 28JUL2005

2. What is ICP-MS? 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 H He Li Be B C N O F Ne Na Mg Al Si P S Cl Ar K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr Rb St Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe Cs Ba L Hf Ta W Re Os Ir Pt Au Hg Tl Pb Bi Po At Rn Fr Ra A Rf Db Sg Bh Hs Mt La Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu Ac Th Pa U Np Pu Am Cm Bk Cf Es Fm Md No Lr

3. Atomic Spectroscopy (I)
Atomic Absorption Spectroscopy
Graphite Furnace AAS
ICP-Mass Spectroscopy
Inductively Coupled Plasma -
Optical Emission Spectroscopy
Nucleus
Electron

4. Atomic Spectroscopy (II)
FAAS
High Precision
ICP-MS
Quantitation
Sensitivity
GFAAS
High Sensitivity
Low Detection Limits
ICP-OES
Multi-element Simultaneous Analysis
Spectral Interferences

5. ICP-MS Schematic Diagram
5. Isolation Valve
8. Detector
3. Plasma
2. Spray Chamber
7. Mass Filter
4. Off-axis Lens
6. ORS
1. Nebulizer

6. Sample Introduction Device
Ar blend gas
To ICP
Babington
Nebulizer
Al insulation
Sample solution
cover
Ar carrier gas
Peltier cooling device
Cooling water

7. Mass flow Control Auxiliary Gas (1L/min) Carrier Gas (1.2L/min) +
6. Ion Lenses
2. Spray Chamber
4. Interface
Auxiliary Gas (1L/min)
Carrier Gas (1.2L/min) +
Sample Blend Gas (0.6L/min)
Plasma Gas (15~16L/min)

8. + Ionization by Plasma ID 2.5mm, Flow 0.2~0.4ml/min 1. Drying
2. Spray Chamber
ID 2.5mm, Flow 0.2~0.4ml/min
1. Drying
3. Atomization
4. Ionization
2. Decomposition

9. Distribution of Plasma
27.12MHz S
Sample
40MHz
27.12MHz S
40MHz

10. Cool Plasma Interference 39K 38Ar1H 40Ca 40Ar 56Fe 40Ar16O Work coil
Torch
Shield plate

11. Cool Plasma Normal Plasma Cool Plasma Shield plate
Forward Power: 1300W
Sampling Depth: 7mm
Carrier Gas Flow: 1.2ml/min
Forward Power: 900W
Sampling Depth: 13mm
Carrier Gas Flow: 1.7ml/min

12. Ionization EfficiencyMg
Mg, Fe, As Fe Cl As Ar Cl Ar

13. Optimum gas flow Co
Sensitivity
ArH
ArO
Carrier gas flow

14. Extraction Lens
Twin Extraction
Lenses
Sampling cone
Skimmer cone

15. Why need ORS?
Interference
Matrix
39K
38Ar1H
UPW
40Ca
40Ar
56Fe
40Ar16O
51V
35Cl16O
HCl
52Cr
35Cl16O1H
75As
40Ar35Cl
48Ti
32S16O
H2SO4
64Zn
32S16O16O
63Cu
31P16O16O
H3PO4
68Zn
31P18O18O1H
24Mg
12C12C
Organics
40Ar12C
There are some applications where
cool plasma does not meet current and
future required performance levels for
certain analytes:
several interfered analytes in high ( ppm) Si matrices
interfered analytes (Ti, Zn) in high matrix acids H2SO4 and H3PO4
Agilent’s Octopole Reaction Cell can remove these interferences…

16. Off-axis Lens

17. Dissociation He As
75amu
75amu Ar Cl
40amu
35amu Ar Cl
75amu Ar Cl

18. Energy Transfer As He 75amu Ar Cl 75amu Electric Potential
(Quadrupole)

19. Reaction mode Charge Transfer Ar+ + H2 H2+ + Ar (neutral)
Proton Transfer
Ar2+ + H2 Ar2H+ + H
(80amu) (81amu)

20. Mass Filter 3MHz True Hyperbolic Quadrupole 3MHz RF Generator
Peak Shape
Abundance Sensitivity
3MHz

21. Dual Electron Multiplier
Fast Analogue
Detection
Pulse Counting
Detection M+ e e
Dynode

22. Wide Dynamic Range Dynamic Range: 9 orders Analog Mode
1000ppm
Dynamic Range: 9 orders
Analog Mode
Pulse Counting Mode
Solid type Multiplier
1ppt

23. ICP-MS Schematic Diagram
5. Isolation Valve
8. Detector
3. Plasma
2. Spray Chamber
7. Mass Filter
4. Off-axis Lens
6. ORS
1. Nebulizer

24. Flexibility [I-Autosampler] [HPLC-ICP-MS] [ORS Technology] [GC-ICP-MS]
[Organic Kit]

25. Sample Type Waters Chemicals Semiconductor Food Geological Clinical
Forensic
Petrochemical
Nuclear