3. Components of Blood Whole blood –RBCs –WBCs –Platelets: cell fragments that aid in clotting Plasma –90% water (allows materials to dissolve) –Amino acids, glucose, hormones, vitamins, salts, waste –Concentrations allows diffusion in/out of blood stream

4. Red Blood Cells Job: Transport O2 to cells Produced from stem cells in bone marrow O2 binds to hemoglobin proteins Dead cells filtered by liver & spleen

5. NormalSickle Cell

6. White Blood Cells Remove foreign invaders & dead cells Able to move through body tissue

7. Platelets Form clots when bleeding Proteins form a web to trap cells & platelets

8. Proteins on blood cells determine blood type Antigen (markers) –proteins on cell’s surface that identify cells as foreign or natural Antibodies: –proteins from B cells to attack invaders –Float freely in plasma ABO Blood Groups

9. Group A blood A antigens on the surface of your RBCs B antibodies in your blood plasma

10. Group B blood B antigens on the surface of your RBCs A antibodies in your blood plasma

11. Group AB blood Both A and B antigens on the surface of your RBCs Neither A or B antibodies in your blood plasma

12. Group O blood Neither A or B antigens on the surface of your RBCs Both A and B antibodies in your blood plasma

13. If you have type A blood, can you receive: Type B blood from a donor? Type AB blood from a donor? Type O blood from a donor?

14. If you have type B blood, can you receive: Type A blood from a donor? Type AB blood from a donor? Type O blood from a donor?

15. If you have type AB blood, can you receive: Type A blood from a donor? Type B blood from a donor? Type O blood from a donor?

16. If you have type O blood, can you receive: Type A blood from a donor? Type B blood from a donor? Type AB blood from a donor?

18. Rh Factors If Rh+ –Cells contain the Rh antigen –Can receive Rh+ or Rh- blood If Rh- –Cells lack the Rh antigen –Plasma contains Rh antibody –Only receive Rh- blood

19. Francis was just in a bad accident and lost a lot of blood. He is blood type B+. Can you help save him?

20. Blood type B+ Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

21. Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive B+ blood? Yes. A antibody Francis has B+ blood type because of the B and Rh antigens. If he is given B+ blood in a transfusion… Vein

22. Francis has B+ blood type because of the B and Rh antigens. If he is given B- blood in a transfusion… A antibody Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive B- blood? Yes. Vein

23. Francis has B+ blood type because of the B and Rh antigens. If he is given A+ blood in a transfusion… Will his antibodies attack this blood? Yes. His A antibodies will attack the A antigens. Can he receive A+ blood? No. A antibody Vein Agglutination: clumping of the blood

24. Francis has B+ blood type because of the B and Rh antigens. If he is given A- blood in a transfusion… Will his antibodies attack this blood? Yes. His A antibodies will attack the A antigens. Can he receive A- blood? No. A antibody Vein Agglutination: clumping of the blood

25. Francis has B+ blood type because of the B and Rh antigens. If he is given AB+ blood in a transfusion… Will his antibodies attack this blood? Yes. His A antibodies will attack the A antigens. Can he receive AB+ blood? No. A antibody Vein Agglutination: clumping of the blood

26. Francis has B+ blood type because of the B and Rh antigens. If he is given AB- blood in a transfusion… Will his antibodies attack this blood? Yes. His A antibodies will attack the A antigens. Can he receive AB- blood? No. A antibody Vein Agglutination: clumping of the blood

27. Francis has B+ blood type because of the B and Rh antigens. If he is given O+ blood in a transfusion… Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive O+ blood? Yes. A antibody Vein

28. Francis has B+ blood type because of the B and Rh antigens. If he is given O- blood in a transfusion… A antibody Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive O- blood? Yes. Vein

29. Sebastian was just involved in an accident at work and lost a lot of blood. He is blood type A-. Can you help save him?

30. Blood type A- Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

31. Sebastian has A- blood type because of the A antigen. If he is given A- blood in a transfusion… Will his antibodies attack this blood? No. His B and Rh antibodies only attack B and Rh antigens. Can he receive A- blood? Yes. B antibody Rh antibody B antibody Rh antibody B antibody Vein

32. Sebastian has A- blood type because of the A antigen. If he is given A+ blood in a transfusion… B antibody Will his antibodies attack this blood? Yes. His Rh antibodies will attack the donated Rh antigens. Can he receive A+ blood? No. Rh antibody Agglutination: clumping of the blood Vein

33. Sebastian has A- blood type because of the A antigen. If he is given B- blood in a transfusion… Rh antibody Will his antibodies attack this blood? Yes. His B antibodies will attack the donated B antigens. Can he receive B- blood? No. B antibody Agglutination: clumping of the blood Vein

34. Sebastian has A- blood type because of the A antigen. If he is given B+ blood in a transfusion… Will his antibodies attack this blood? Yes. Both his B and Rh antibodies will attack the donated B an Rh antigens. Can he receive B+ blood? No. B antibody Rh antibody B antibody Rh antibody B antibody Agglutination: clumping of the blood Vein

35. Sebastian has A- blood type because of the A antigen. If he is given AB- blood in a transfusion… Rh antibody Will his antibodies attack this blood? Yes. His B antibodies will attack the donated B antigens. Can he receive AB- blood? No. B antibody Agglutination: clumping of the blood Vein

36. Sebastian has A- blood type because of the A antigen. If he is given AB+ blood in a transfusion… Will his antibodies attack this blood? Yes. Both his B and Rh antibodies will attack the donated B and Rh antigens. Can he receive AB+ blood? No. B antibody Rh antibody B antibody Rh antibody B antibody Agglutination: clumping of the blood Vein

37. Sebastian has A- blood type because of the A antigen. If he is given O+ blood in a transfusion… B antibody Will his antibodies attack this blood? Yes. His Rh antibodies will attack the donated Rh antigens. Can he receive O+ blood? No. Rh antibody Agglutination: clumping of the blood Vein

38. Sebastian has A- blood type because of the A antigen. If he is given O- blood in a transfusion… B antibody Rh antibody B antibody Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive O- blood? Yes. Rh antibody B antibody Vein

39. Blood type AB+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

40. Blood type O+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

41. Blood type AB- Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

42. Blood type B+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

43. Blood type O- Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

44. 1) Can this work? Acceptor O- Donor AB-

45. 2) Can this work? Acceptor A+ Donor A-

46. 3) Can this work? Acceptor AB- Donor B-

47. Kobe Kuiz 1)What are the components found inside blood? 2)What are the ingredients of plasma? 3)What is the purpose/function of RBCs? 4)Which part of blood stop bleeding when cut? 5)What do antibodies bind with? 6)If a person has type AB-, which antigens do they possess? Which antibodies? 7)If a person has type O+, which antigens do they possess? Which antibodies? 8)If a person is type A-, list all the blood types this person can receive in a transfusion. 9)If a person is type O-, list all the blood types this person can receive in a transfusion.