1. Organs for research and education Matthew Bock

2. When are organs used for research? Only after they have been determined unsuitable for transplant

3. What makes an organ unsuitable for transplant? Performance Performance Condition Condition

4. Performance KidneysCreatinineLiverAST/ALTPancreasA1CHeart Troponin, Echo Troponin, Echo Lungs X-ray, PO2

5. Condition Fatty pancreas Fatty pancreas Polycystic kidney Polycystic kidney Fibrotic or fatty liver Fibrotic or fatty liver

6. If we can’t transplant… There is still an option… Research consent

9. Page 2 (back) of consent form

11. Research consent for transplanted organs Liver study Liver study Biopsy Biopsy Lung study Lung study Bronch washings and blood ample Bronch washings and blood ample Kidney study Kidney study

12. Order 1 st - Transplant 1 st - Transplant 2 nd - In-house research 2 nd - In-house research 3 rd - National 3 rd - National

13. Order 1 st - Transplant 1 st - Transplant 2 nd - In-house research 2 nd - In-house research 3 rd - National 3 rd - National

14. Order 1 st - Transplant 1 st - Transplant 2 nd - In-house research 2 nd - In-house research Pancreas islet cells Pancreas islet cells 3 rd - National 3 rd - National

15. Order 1 st - Transplant 1 st - Transplant 2 nd - In-house research 2 nd - In-house research 3 rd - National 3 rd - National

16. Order 1 st - Transplant 1 st - Transplant 2 nd - In-house research 2 nd - In-house research 3 rd - National 3 rd - National NDRI NDRI IIAM IIAM

17. Who are NDRI and IIAM? NDRI, National disease research interchange NDRI, National disease research interchange IIAM, International Institute for the Advancement of Medicine IIAM, International Institute for the Advancement of Medicine Both are 501c non-profit Both are 501c non-profit

18. Heart Heart, Arteries and Veins Medical investigators use the human heart to learn about the development of atherosclerosis in coronary arteries

19. Kidneys Renal tissues is used to study the toxicity of anti-cancer therapies and to study the safe concentrations of other drugs in development Renal tissues is used to study the toxicity of anti-cancer therapies and to study the safe concentrations of other drugs in development

20. Lungs Research into chronic obstructive pulmonary disease (COPD), cystic fibrosis, asthma, emphysema and allergies Research into chronic obstructive pulmonary disease (COPD), cystic fibrosis, asthma, emphysema and allergies

21. Pancres Diabetes researchers rely on pancreatic tissues to explore the regulation of insulin production, to identify the genetic components of the disease and for toxicity studies on new compounds.

22. Liver Hepatocyte cell isolation for transplantation Hepatocyte cell isolation for transplantation Human model for drug interaction, toxicity and metabolism testing Human model for drug interaction, toxicity and metabolism testing

23. Education Whole body donation Whole body donation