1. Endocrinology By Allison and Karina

2. Name the endocrine organs… Hypothalamus Adrenal Pancreas Kidney Ovary Uterus Pituitary Thyroid Thymus Testes

3. What are the three main types of hormones? 1.Polypeptide 2.Steroids 3.Modified amino acids

4. How are hormones made?

5. Screen Shot 2014-10-07 at 13.55.28

6. Signalling cell close to Signalling and target cell the same Signalling cell Target cell Signalling molecule travel in blood to target cell Name the types of chemical communication…

7. Talking to yourselfConversation/meeting Phone call Paracrine signalling Endocrine signalling Autocrine signalling Signalling cell close to Signalling and target cell the same Signalling cell Target cell Signalling molecule travel in blood to target cell

8. How are steroid and peptide hormones transported in the blood? Peptides = dissolve in blood (as they are hydrophillic) and bind to cell surface receptors Steroids (and thyroid) = transported attached to binding proteins because they are hydrophobic. Bind to cell surface OR intracellular receptors.

9. Feedback Control Hypothalamus Anterior pituitary Target endocrine gland Releasing hormone Trophic hormone Hormone - -

10. Cortisol

11. Feedback Control Hypothalamus Anterior pituitary Target endocrine gland Releasing hormone Trophic hormone Hormone Corticotrophin releasing hormone (CRH) Adrenocorticotrophic hormone (ACTH) Cortisol Adrenal gland

12. What are the functions of cortisol? Connective tissue  Lets the baby grow Immune functions inhibited Muscle mass  Bone function 

13. What are the symptoms of having too much cortisol? CUSHINGS Depression Insomnia Psychosis Libido lowered Obesity (central) Moon face Amennhorrea Striae

14. What do you predict will happen to the hormones in this loop (high, low or normal) when Cushing’s syndrome is being caused by: a) hypothalamus, b) anterior pituitary, c) adrenal gland:

16. What is Addison’s condition? Adrenal insufficiency. Adrenal glands do not produce sufficient steroid hormones: cortisol and aldosterone.

17. What are the symptoms of Addison’s? Back pain Anorexia Nausea/ vomiting Diarrhoea Abdo pain Impotence Depression

18. Formative Style Questions

19. Which of the following best describes hormones? 1.Work only in the area adjacent to the gland that produced them 2.All are lipid soluble 3.Chemical messengers that are released into the environment 4.Hormones are stable, long lasting chemicals released from glands

20. What part of the cell is involved in steroid synthesis? A.Smooth endoplasmic reticulum B.Rough endoplasmic reticulum C.Golgi apparatus D.Nucleus

21. What does paracrine mean? A.To self B.To a nearby cell C.To a distant cell D.Into a duct