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Chapter 8 Cell Adhesion Molecules (CAM)
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Chapter 8 Cell Adhesion Molecules
Contents PartⅠ Membrane molecules of immune cell PartⅡ Definition of leukocyte differentiation antigen and CD PartⅢ Definition, classification and functions of adhesion molecules PartⅣ Clinical application of CD and adhesion molecules
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PartⅠ Membrane molecules of immune cell
Receptors: TCR, BCR, CR, CKR, FcR ClassⅠand classⅡ MHC molecules CD molecules: CD1~339 Cell Adhesion Molecules
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PartⅡ Definition of leukocyte differentiation antigen and CD
Leukocyte differentiation antigen: Cell surface molecules expressed (or disappeared) during different developmental and differential phases, activation or inactivation process of blood cells.
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PartⅡ Definition of leukocyte differentiation antigen and CD
CD: cluster of differentiation. The same differentiation antigen recognized by different monoclonal antibody from different lab are called CD.
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CDs which take part in T cell recognition, adhesion and activation
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CDs which take part in B cell recognition, adhesion and activation
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PartⅢ Definition, classification and functions of adhesion molecules
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Ⅰ. Definition Cell adhesion molecules (CAMs) are cell surface proteins involved in the interaction of cell-cell or cell-extracellular matrix. CAMs take effect by the binding of receptor and ligand.
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Ⅱ. Classification Integrin family Selectin family
Immunoglobulin (Ig) superfamily Cadherin family Mucin-like family Other adhesion molecules
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1. Integrin family Integrins consist of α and β chains.
According to β subunits, Integrins are divided into eight groups: β1- β8 VLA-4(Very Late Antigen-4)------VCAM-1 LFA-1(Lymphocyte Function-associated Antigen-1)------ICAM-1,2,3 MAdCAM-1 (Mucosal Addressin Cell Adhesion Molecule-1) TSP-1 ((Thrombospondin一1):凝血酶敏感蛋白一1
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Integrin and platelet aggregation
(Karp, 2001)
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Integrins promote immune response
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2. Selectin family Selectins consist of one peptide chain.
The three family members include: E-selectin, L-selectin, and P-selectin.
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3. Ig superfamily(IgSF) The structure of these adhesion molecules resemble that of Ig. CD4, CD8, CD2(LFA-2), CD58(LFA-3), VCAM-1, ICAM-1,2,3
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4. Cadherin family E-cadherin------ Epithelia cell
N-cadherin Nerve cell P-cadherin Placenta
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5. Mucin-like family CD34, GlyCAM-1(glycosylation dependent cell adhesion molecule-1) PSGL-1(P-selectin glycoprotein ligand-1) Other adhesion molecules CD44
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Ⅲ. Functions Participate in development and differentiation of immune cells CD2----LFA-3 LFA-1----ICAM-1 Participate in development and maturation of thymocytes.
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2.Participate in immune response and regulation
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3. Participate in the adhesion of leukocyte and vascular endothelial cell during inflammation.
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4. Participate in lymphocyte homing
Lymphoid stem cell migrate to central lymphoid organs. Mature lymphocyte migrate to peripheral lymphoid organs Recirculation of lymphocytes Lymphocyte migrate to the sites of inflammation
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5. Participate in regulation of apoptosis
Integrins inhibit cell apoptosis
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