2. 200420032005 S1 30 MINUTE WARMUP 15 MINUTE CALIBRATION pCAL STANDARDS 3 MINUTE SCAN 200120002002 FIRST SCANNER UNIVERSITY OF UTAH 10’ X 10’ LIQUID NITROGEN REQUIRED

3. 200720062008 S2 5 MINUTE WARMUP 90 SECOND SCAN ELIMINATE pCAL WITH EVEREST VERSION LAPTOP AND BARCODE READER REQUIRED 200420032005 S1 30 MINUTE WARMUP 15 MINUTE CALIBRATION 3 MINUTE SCAN pCAL STANDARDS

4. FASTER PORTABLE SMALLER DIGITAL INTRODUCING 200820072009 S2 5 MINUTE WARMUP 90 SECOND SCAN ELIMINATE pCAL WITH EVEREST VERSION LAPTOP AND BARCODE READER REQUIRED

5. 0:30 S3 1:30 S2 3:00 S1

6. 7.5 kg 5.4 kg 1.7 kg

7. EXTENDED BATTERY LIFE 500+ SCANS ON 1 CHARGE. YOU’LL RUN OUT OF ENERGY BEFORE IT DOES. WIRELESS CONNECTIVITY BLUETOOTH LE. NO WIRES NEEDED TO PERFORM A SCAN. iPAD SCANNER APP IPAD MINI IS USED TO RUN THE SCANNER WIRELESSLY.

8. DIGITAL SCANS NEW OPTION TO BUY AND USE DIGITAL SCANS SCAN CARDS USE OF PHYSICAL SCAN CARDS WILL CONTINUE TO BE AN OPTION ELIMINATES THE NEED FOR PHYSICAL CARDS

9. 2 1 3 Scanner Plant Calibrates Scanner Using Same Methods as S2 Scanner Plant Performs QA Inspection on Each Scanner Scanner Plant Ships Scanner to Market

10. 5 4 Upon Receipt, Market Performs QA Check on Every Scanner Before Packaging for Shipment to Distributor—Using Same Criteria as Scanner Plant Scanners that Fail QA Tests in Market Return to Scanner Plant for Rework

12. ZEAXANTHIN ASTAXANTHIN BETA-CAROTENE LUTEIN LYCOPENE

13. ZEAXANTHIN ASTAXANTHIN BETA-CAROTENE LUTEIN LYCOPENE The National Academy of Sciences concluded “Tissue concentrations of carotenoids are the best biological markers for consumption of fruit and vegetables.”

14. MEASURING LEVELS AT PARTS PER BILLION CAROTENOID 473 nm PHOTONS RAMAN SPECTROSCOPY 510 nm PHOTONS

15. If we were to liken a carotenoid to a grain of sand, a typical scan session would be like searching for 40 “special” grains of sand in an area covered with 2.4 trillion grains of normal sand. If you lined up every grain of that sand, then it would cover the Dune of Pilat in France, twice!—with a 1mm deep layer of sand.

16. Imagine you have a super-camera that could scan the 2 dunes of sand all at once and a computer in the camera counted the special grains hidden among the 2.4 trillion other grains. Such a super-camera would not be able to tell you the exact number every time. Instead it would give an estimate of how many of the special grains the computer thinks it sees. So rather than spending your entire life counting the grains, you use your super-camera to take a picture to find the 40 special gains and the computer tells you there are 37 special grains. You decide to take the picture again just to be sure. This time the computer tells you there are 44 grains. Neither score is perfect, but both scores give you a good idea of the true value.

18. All equipment is subject to variability when performing a measurement. It is not a question of whether there is going to be variation. It is a question of how much variation exists. It can only be reduced and managed through proper usage, maintenance, calibration, and other methods.

19. 1.Is the BPS “more variable” than other similar equipment? 2.Is the S3 BPS “more variable” than the S2? QUESTIONS:

20. Pharmanex R&D conducted a research project to evaluate S3 device variability. 3,600 total scans 10 different S3 devices 30 scans on each device per session 3 different scan sessions per subject in a 7 day period 4 different subjects The S3 is marketed to have an acceptable device variability of 9,000 points (or 3 ‘color shades’). This is roughly a 15% variability. Testing of the device shows that the S3 performs at or above this expectation in 85% of all cases. Other experiments have shown the S3 regularly outperforms this standard. AVERAGE S3 TEST RESULT VARIABILITY: 1,975 POINTS OR 3.29%

21. AVERAGE S3 TEST RESULT VARIABILITY: 1,975 POINTS OR 3.29% High or low temperaturesInconsistent hand placement Improper hand placementS3 not allowed to acclimate Improper hand pressureS3 stored in extreme temperatures Poor posture while scanningPoor arm positioning while scanning SOME THINGS THAT CAN GIVE YOU A “BAD READING”

22. 41,000 43,000 39,000 40,000 43,000 45,000 38,000 37,000 41,000 36,000 44,000 THV SCAN 10 TIMES

23. 41,000 43,000 39,000 40,000 43,000 45,000 38,000 37,000 41,000 36,000 44,000 THV SCAN 10 TIMES ONE COLOR SHADE + - ONE COLOR SHADE 85% of the Time

24. SCORE MEASUREMENT NUMBER 60 50 40 30 20 10 0

25. Pharmanex R&D conducted a research project to evaluate S2 device variability. 450 total scans 5 different S2 devices 30 scans on each device per session 3 different scan sessions per subject in a 7 day period The S2 is marketed to have an acceptable device variability of 9,000 points (or 3 ‘color shades’). This is roughly a 15% variability. Testing of the device shows that the S2 performs at or above this expectation in 85% of all cases. Other experiments have shown the S2 regularly outperforms this standard. AVERAGE S2 TEST RESULT VARIABILITY: 2,484 POINTS OR 4.14%

26. AVERAGE S2 TEST RESULT VARIABILITY: 2,484 POINTS OR 4.14% High or low temperaturesInconsistent hand placement Improper hand placementS2 not allowed to acclimate Improper hand pressureS2 stored in extreme temperatures Poor posture while scanningPoor arm positioning while scanning SOME THINGS THAT CAN GIVE YOU A “BAD READING”

28. An important way to reduce BPS variability is to be as repeatable and consistent as possible in hand placement on the scanner probe. Inconsistent hand placement is a known variable that can increase score fluctuation. The experiment below tests the variability of a subject when moving the hand only 0.5 cm (5mm) away from the target hand point for scanning. Hand placementScan 1Scan 2Scan 3AVERAGEVARIABILITY Proper Placement 141,41642,82042,20242,146N/A 0.5 cm left47,22746,98349,73747,982+5,800 0.5 cm right43,18841,60845,02143,272+1,100 0.5 cm up54,70156,35954,44055,167+13,000 0.5 cm down47,85347,10147,11747,357+5,200 Proper Placement 242,35143,19643,25742,935+800 Hand Placement Hand placementScan 1Scan 2Scan 3AVERAGEVARIABILITY Proper Placement 141,41642,82042,20242,146N/A 0.5 cm left47,22746,98349,73747,982+5,800 0.5 cm right43,18841,60845,02143,272+1,100 0.5 cm up54,70156,35954,44055,167+13,000 0.5 cm down47,85347,10147,11747,357+5,200 Proper Placement 242,35143,19643,25742,935+800

29. An important way to reduce BPS variability is to be as repeatable and consistent as possible in hand placement on the scanner probe. Inconsistent hand placement is a known variable that can increase score fluctuation. The experiment below tests the variability of a subject when moving the hand only 0.5 cm (5mm) away from the target hand point for scanning. Hand Placement

30. BPS scores can also vary depending on the amount of hand pressure the subject uses while scanning. The experiment below tests how much score can vary when a subject uses ‘light’ hand pressure versus ‘hard’ hand pressure. Hand Pressure Subject Light pressure 10 scan average Hard pressure 10 scan average Variation due to hand pressure Subject 142,927.250,474.5 +7,547.3 Subject 234,932.839,062.9 +4,130.1 Subject 373,074.274,882.9 +1,808.7

31. BPS scores can also vary depending on the amount of hand pressure the subject uses while scanning. The experiment below tests how much score can vary when a subject uses ‘light’ hand pressure versus ‘hard’ hand pressure. Hand Pressure Higher hand pressure appears to have a tendency to increase scanner scores. However, this effect does not appear to be universal for all subjects. The person with the highest score also had the least amount of pressure variability. Hand pressure is an important variable to manage for some individuals as a means of controlling score variability.

32. The temperature of the BPS, the environment in which the BPS is stored, and the temperature where it is operated can all impact score variability. Experiments have been conducted to measure the effect of temperature on BPS performance. TEMPERATURE ConditionsScan 1Scan 2Scan 3 AVERAGEVARIABILITY Proper Placement 141,41642,82042,202 42,146N/A Proper Placement 242,35143,19643,257 42,935+800 Cold (30 minutes @ 0° F/-18°C)47,71948,65948,804 48,394+6,248 Hot (20 minutes @ 120° F/ 49°C)45,24749,08948,513 47,616+5,470 Proper Placement 3*44,52543,74042,400 43,555+1,409 *After scanner acclimated to normal temperature (75° F)

33. What to do if someone’s score seems to be “too high” or “too low: 1.Scan three times or more 2.Take an average to determine an estimate for the THV (True Hand Value) 3.Explain the scanner variability SCORE SINGLE SCAN DISTRIBUTION 60 50 40 30 20 10 3-SCAN AVERAGE

34. Both the S2 and the S3 devices have variability levels that are superior or comparable to other similar devices. There are other existing carotenoid tools which have less variability than the S2 or S3. This includes High Performance Liquid Chromatography (HPLC). These tools are considered to fall outside the scope of the S3 device (laboratory analysis). The S3 is not more variable than the S2. Repeated experiments have shown a tendency for the S3 to be slightly less variable than the S2.

35. Great improvements have been made over the years, making the scanner faster, portable, and more convenient. The S3, like other devices, is subject to variability which, with proper care, can be managed and also taught to customers. With proper treatment, best practices, and timely calibration, the S3 can be a very effective tool to assess the amount of carotenoids incorporated in the skin and promote one’s business.