1. Prevalence of Helicobacter pylori infection in chronic dyspeptic patients with peptic ulcer in Naresuan University Hospital Researchers Rutnumnoi Thanachat 52460390 Ridamrong Waraporn 52460888 Advisors Jiratwang Manatchanok, MD. Lertkajornsin Suwit, MD.

2. Background Helicobacter pylori Gram-negative, curved S-shaped, microaerophilic bacterium Most common cause of gastritis, peptic and duodenal ulcers and gastric adenocarcinoma

3. Objectives To find out the prevalence of H. pylori infection in chronic dyspeptic patients with peptic ulcer. To explore the relationship between the characteristics of ulcer and the H. pylori infection.

4. Method A cross-sectional descriptive study was performed by collecting data in EGD clinic, Naresuan University hospital during October 2004 to August 2012. The diagnosis of Helicobacter pylori infection was done by Rapid Urease Test and Histological examination. Stataversion12 was used to conclude the information.

5. Method Inclusion criteria – Patients with dyspepsia which had been diagnosed by a specialist. – Patients who underwent upper gastrointestinal endoscopy clinic at Naresuan University Hospital with indication of Dyspepsia. – Patients with Helicobacter pylori infection results diagnosed by Rapid Urease Test and / or Histological Examination.

6. Method Exclusion criteria – Patients with other indications for upper gastrointestinal endoscopy beyond dyspepsia. – Patients who were diagnosed as Helicobacter pylori infection by both Rapid Urease Test and Histological Examination.

7. Method Chronic dyspeptic patients who underwent the EGD at NUH during Oct 2004 to Aug 2012 53 patients

8. Results Variables200420052006200720082009201020112012Total Sex Male16322404325 Female13416342428 Age Min5843455351 476561 Max74777477 85598183 Mean66.0052.2257.1464.6764.5066.2952.2570.8370.2962.81 SD11.3110.1211.1412.019.2311.465.746.527.1610.82 Table 1 : Demographic data of chronic dyspeptic patients with peptic ulcer who underwent EGD at NUH between Oct 2004 – Aug 2012.

9. Results 7.55% 90.57% 1.88% Bar graph 1 : Endoscopic findings of Chronic dyspeptic patients with peptic ulcer who underwent EGD at NUH between Oct 2004 – Aug 2012.

10. Results 66.04% 33.96% Bar graph 2 : Rapid urease test results for detection of Helicobacter pylori infection in Chronic dyspeptic patients with peptic ulcer who underwent EGD at NUH between Oct 2004 – Aug 2012.

11. Results : Bar graph 3 66.67% 33.33% Bar graph 3 : Histological examination results for detection of Helicobacter pylori infection in Chronic dyspeptic patients with peptic ulcer who underwent EGD at NUH between Oct 2004 – Aug 2012.

12. Results Endoscopic Findings Rapid Urease Test ResultsTotal P Value 0.275 H. pylori Positive (n) H. pylori Positive (%) H. pylori Negative (n) H. pylori Negative (%) GU1531.253368.7548 90.57 DU250.002 4 7.55 GU + DU1100.0000.001 1.89 Total1833.963566.0453 Table 2 : The relationship between Rapid urease test results for detection of Helicobacter pylori infection in Chronic dyspeptic patients who underwent EGD at NUH between Oct 2004 – Aug 2012. and endoscopic findings

13. Results Endoscopic Findings Histological Examination ResultsTotal P Value 0.667 H. pylori Positive (n) H. pylori Positive (%) H. pylori Negative (n) H. pylori Negative (%) GU562.50337.508 88.89 DU1100.0000.001 11.11 GU + DU----- Total666.67333.339 Table 3 : The relationship between Histological examination results for detection of Helicobacter pylori infection in Chronic dyspeptic patients who underwent EGD at NUH between Oct 2004 – Aug 2012. and endoscopic findings

14. Results TotalNotes Patients53- Rapid Urease Test Positive 18- Histological Examination Positive 6 Histological Examination Positive with Rapid Urease Test Positive 4 Only Histological Examination Positive 2 The prevalence was 37.74% (20 of 53 patients) Table 4 : The prevalence of Helicobacter pylori infection in patients with Chronic dyspeptic patients with peptic ulcer who underwent the EGD at NUH between October 2004 - August 2012.

15. Conclusion The prevalence of H. pylori infection was still high in the chronic dyspeptic patients with peptic ulcer. This may relate to GU, DU and combined GU and DU. There was no significant difference in relationship between endoscopic findings and Helicobacter pylori infection which detected by Rapid urease test or Histological examination.

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