1. Low Cost Fundus Camera P15590 Presented by: Daniel Sui, Ian Morency, Kevin Labourdette, Kyle Burden, Thomas Casero, Quang Huynh December 4 th, 2014

2. ●Introduction and Background ●Major Subsystem Design Feasibility Discussion ●Expected Performance Against Requirements ●Bill of Materials and Budget Review ●Updated Test Plan for Requirements ●Overview of Risk Assessment ●MSD II Plan Overview

3. ●Risk of Diabetes ○Diabetic Retinopathy ■Vein Damage ●No Regular Checkups ○Increased Risk ●Fundus Camera ○Reduce Risk with regular checkups ■Many drawbacks ●Our Goals ○More screenings ○Low Cost Device ○No medically-induced dilation Background

4. ●MSD I & II Goal: Develop an alpha prototype fundus camera system capable of taken a diagnosable photo to confirm feasibility ●Prove or Disprove feasibility of using RPi Camera Module ●Second term will be focused on testing and re-testing options to confirm feasibility Current Project Status

5. Feasibility of RPi Camera Module

6. ●For a given camera F/#, focal length, and sensor size→ along with the focal length of the eye and the size of the pupil, this sets the Magnification of the system ●This will determine the mapping of space in object space to image space Feasibility of RPi Camera Module

8. ●Talked to Pedro ○Amount of light the camera accepts determines FOV ○Current Camera won’t work as is ■20.04 degrees, assuming lighted conditions ○Lens modifications alter F#, allow more light, increase FOV ●Many cameras can work with the RPi Feasibility of RPi Camera Module

10. ●Two Main Subsystems ○Imaging ■Illumination ●Red, IR, White ■Camera ■Imaging optics ●Beam Splitters ●Cornea Image ●Retina Image ○Fixation ■Pupil alignment Test Bench Layout

11. ●Internal Fixation ○Eyes move in tandem ○One eye focuses ○Other eye is imaged ●Benefits ○Fewer components ○Widens FOV Test Bench Layout - Fixation Subsystem

13. ●Exact geometry of imaging subsystem has yet to be defined, items not shown: ○Camera Mount ○Imaging Cover ○Controller ○Adjustable Focus ■Stepper Motor ■Spring Return ■Slide Test Bench

14. ●Option 1 ●LED on Metal Core PCB ○Bare Minimum ○$50-$55 ea. ○Pros: Cost ○Cons: Need to make fixturing Lighting - Options

15. ●Option 2 ●Mounted LED on Metal Core PCB ○Next Step Up ○$187-$205 ea. ○Pros: Premounted, has cable, lower risk, cooling fins ○Cons: Larger, more expensive Lighting - Options

16. ●Option 3 ●Mounted LED on Metal Core PCB ○Next Step Up ○$430-$480 ea. ○Pros: Premounted, has cable, collimated, lowest risk ○Cons: Cost, Size Lighting - Options

17. Electrical Component Schematic

18. Power Analysis ●R Pi B+ (max 2000 mA) ○Camera Module ○Illumination LEDs ○Stepper Motors ○USB Keyboard ●7 “ Touch Screen ○Uses its own power supply Current Raspberry Pi B+550 mA Camera Module250 mA Illumination LEDs650 mA Stepper Motor200 mA USB Keyboard100 mA Total1750 mA

19. ●Improving Last Design ○Talking to Medical Professionals ■Simplicity and Usability ■Testing early prototypes ●Working with Casters ○Support Feasible? ○Retractable or locking? ○How much will the system weigh? Industrial Design Update

20. ●Industrial Design: Low Priority ○Support system very simple ○Optimizing for our purpose Expected Performance Against Requirements

21. ●Mechanics: Medium Priority ○RPi-motor interface well-known ○Few moving parts Expected Performance Against Requirements

22. ●Electronics: Medium Priority ○Vast amount of RPi System documentation ○Simple GUI and components Expected Performance Against Requirements

23. ●Optical systems: High Priority ○Central Function ○Low level of background knowledge Expected Performance Against Requirements

24. Bill of Materials Part NameDescriptionQtyUnitsUnit CostCost Raspberry Pi B+ "Ultimate Camera Kit", includes RPi B+, Camera, accessories 1each$ 79.99 ULN2803 8 Channel Darlington Driver (Solenoid/Unipolar Stepper) 2each$ 1.95$ 3.90 Small Reduction Stepper Motor5VDC 32-Step 1/16 Gearing2each$ 4.95$ 9.90 7" Touch Screen LCD Monitor TFT monitor for Raspberry Pi+Driver Board HDMI VGA 2AV 1each$ 59.95 Raspberry Pi Camera Lens Adapter Lens adapter for connection of M12/C-Mount lenses 1each$ 155.00

25. Bill of Materials Part NameDescriptionQtyUnitsUnit CostCost C-Mount Camera Lens Standard C-Mount Lens used on good quality cameras (est.) 1each$ 250.00 Thorlabs MWWHL3 White LED Source + Mount Source of natural light for image capture 1each$ 187.51 Red LED Source + Mount Source of light for internal fixation 1each$ 55.00$ 187.51 Thorlabs M735L3 IR LED Source + Mount Source of infrared light for alignment preview 1each$ 205.00 Optical "Breadboard" Bench Mounting plate for optical component testing - donated! 1each$ -

26. Bill of Materials Part NameDescriptionQtyUnitsUnit CostCost Thorlabs LB1757 Target Lens Lens for internal fixation target magnification 1each$ 33.70 Thorlabs Beamsplitter Beam splitters used in optical subsystem (est.) 2each$ 250.00$ 500.00 Retina Lens Precision lens for retinal imaging 1each$ - Cornea LensLens for macro corneal imaging1each$ - Thorlabs LMR1 Optic MountOptical Bench Component4each$ 15.23$ 60.92

27. Bill of Materials Part NameDescriptionQtyUnitsPictureUnit CostCost Thorlabs LMR1 Beamsplitter Mount Optical Bench Component4each$ 15.23$ 60.92 Thorlabs TR3 PostOptical Bench Component10each$ 5.42$ 54.20 Thorlabs UPH3 Post HolderOptical Bench Component10each$ 30.60$ 306.00 Thorlabs SM1RC LED MountOptical Bench Component3each$ 22.00$ 66.00

28. Bill of Materials - 3D Printed Parts Part NameDescriptionQtyUnitsPictureUnit CostCost Camera Mount Optical Bench Component - 3D Printed 1each$ - Internal Fixation Target Target for alignment of eye - 3D Printed 1each$ - Internal Fixation Target Mount Mount for internal fixation target - 3D Printed 1each$ - Internal Fixation Target Cover Prevent environmental interference with system - 3D Printed 1each$ - Imaging Cover Prevent environmental interference with system - 3D Printed 1each$ -

29. ●Still dependent on more detailed optical subsystem ○Light source needs, lens costs etc. ●Updated Total: $2087.99 ○Over 2.5 times current budget ○Conservative estimates, this number will still increase Budget Review

30. ●Borrowed Optical Bench Components ○Could reduce costs to ~$1000 ○Beam splitters are less likely to be borrowed, cost $500 ●Realistic low estimate of ~$1500 ○Still requires borrowed components ○No full optical subsystem Budget Review

31. Test Plan for Requirements

32. ●Bullet One ●Bullet Two ○Sub Bullet One ■Sub-Sub Bullet One Overview of Risk Assessment

33. ●Bullet One ●Bullet Two ○Sub Bullet One ■Sub-Sub Bullet One Overview of Risk Assessment (cont.)

34. MSD II Plan

35. ●Introduction and Background ●Major Subsystem Design Feasibility Discussion ●Expected Performance Against Requirements ●Bill of Materials and Budget Review ●Updated Test Plan for Requirements ●Overview of Risk Assessment ●MSD II Plan Summary

36. Questions