1. Yanhuai Liu, President Beijing East Linden World Traditional Medicine Patent Database

2. Values of TCM Developed and refined over thousands of years by the Chinese people for use in the prevention and treatment of disease, traditional Chinese medicine (TCM) is one of mankind’s greatest treasures. Inner Canon of Huangdi

3. World traditional medicine patent database (WTM) produced by East Linden is the world’s first and only traditional medicine patent database with integration of multinational patent resources. World Traditional Medicine Patent Database

4. Database Coverage Content Over 180K basic patents in traditional /natural medicine field （ over 500K patent family members ） are included. Countries & Organizations CN (TW included) ， US ， JP ， KR ， FR ， DE ， DD ， SU ， RU ， GB ， CA ， AU ， IE, NZ, IN, PH, SG, ZA, IL, NH, EP ， WO Time Scope US : 1985 to present CN: 1985 to present Others: 1985 to 2008

5. Contents & Main Features Bibliographic information Enhanced title, abstract, IPC Chemical structures Indexed terms and codes Therapeutic effects Formulas Patent citations Patent families Patent specifications Multilingual search (e.g. English, Latin and Chinese) Indexed terms search Natural medicine search Chemical structures search Formula and formula similarity search Synonym extension search Statistics analysis

6. Active Ingredient File Formula File Patent Bibliographic Database Patent Full-Text Accompanying Diagram AP/PN AP Uses/Effects Subject Terms Drug Classification Bibliographic Information Compound Registration File WTM Registration File Chemical Structure Searching Specific Structure Search Substructure Search CN Chinese Standard Name Chinese Synonym WTMPD Scheme Search Options English Name English Synonym Chinese Name Chinese Synonym Chinese Systemic Name Chinese Pinyin Chemical Substance CAS Registration No. ( RN) Therapeutic Classification TM Registration No. (CN) Chemical Structure Chinese Standard Name Chinese Synonym Latin Drug Name English Name Chinese Pinyin Latin Plant/Mineral name TM Registration No.

7. Auxiliary Files Natural Medicine File Collect all natural medicine existed in patent documents. More than 13000 records are included Unique code system provides Traditional Medicine Classification (TMC) for TCM. Compound Registry File Collect all active chemical components existed in patent documents. More than 14000 chemical components are included Formula Information File Synonym Dictionary

8. A Record of TCM Unique Code System Medicine RN C002-13C002-04C002-15C002-37C002-16 Chinese names 巴豆巴豆根巴豆壳巴豆霜巴豆油 Chinese synonym 江子 ; 八百力 ; 双 眼龙 ; 双眼虾 ; 巴 豆肉 ; 巴豆仁 巴豆根 ; 独行千里豆双 English names croton fruitcrotonroot efatted croton seed powder Croton Oil English synonym croton seed Latin names Semen Crotonis; Fructus Crotonis Radix Crotonis Pericarppium Crotonis Semen Crotonis Pulveratum Oleum Tiglii Latin plant names Croton tiglium L. Chinese pinyin BADOUBADOUSHUGENBADOUKE BADOUSHUAN G BADOUYOU Family names Euphorbiaceae Generic names Croton

9. World Traditional Medicine Registration File World Traditional Medicine Registration File is designed to collect the natural medicine information all over the world. On the basis of WTM registry file, more than 13,000 medicinal plants and 8,600 source plants are included in the file.

10.  According to the character of natural medicine patent, the patent was classified in eight invention subjects with indexed term code. IT CodesIndexed Terms COMCOMBINATION EXTEXTRACTION FORFORMULATION NTUNEW THERAPEUTIC USE PHYPHYSICAL PROCESS ANAANALYTIC PROCESS BIOBIOLOGICAL PROCESS PLAPLANTING TECHNIQUE Indexed Term (IT)/ IT Code (ITC)

11. Quick Search Search “hypertension” in all the fields Search History List

12. Quick Search Result Search “hypertension” and the synonyms in all the fields

13. Extension Search Result Check detailed patent information by clicking the patent number Set up field

14. A Sample Record Full-text link

15. Full Text Patent Record CN Patent US Patent JP Patent PCT Patent KR Patent

16. Advanced Search Search for TCM containing “Chinese Angelica” used in alopecia treatment Check field code Click expansion search

17. Advanced Search Result 276 search results

18. Refine Search Secondary search entry Refining search result by keying capsule in the abstract field

19. IPC Search Search for IPC related to “materials from plants”

20. Formula Logic Search Specifying number of components contained in target formulas Boolean search entry Specifying therapeutic effect

21. Formula Similarity Search Specifying number of formula components Inputting TCM formula components Narrowing the search result by formula size limitation Setting frequently used TM name list

22. TCM Name List

23. Natural Medicine Search Inputting Drug Name Latin Plant &Mineral Name Registry Number English Name and Synonyms Latin Drug Name Family Name

24. Chemical Structure Search Search for the exact chemical structure Drawing a molecular structure in the panel

25. Chemical Structure Search Result Click to show the original image of chemical structure

26. Sub-structure Search Drawing a molecular structure in the panel Search chemical structures with this substructure

27. 68 hits for substructure search Click to show the original image of chemical structure Sub-structure Search Result

28. Synonyms System Search for synonyms of NIDDM

29. Add user-defined synonym Synonym Search

30. Statistic Analysis Select search query for statistics Select the type for statistics

31. Statistic Analysis

32. User Folder Adding patents into my patent folder

33. WTM Patent Database has been used by patent examiners of SIPO of China as a major prior art database for pharmaceutical field. Workshops of WTMPD in SIPO of China

34. Usages of This Database Prior art search Pharmaceutical research Infringement search Freedom to operate R & D

35. WTMPD Usage Examples The database has been used heavily by examiners at SIPO for prior art search. In 2009, by using our two databases - WTM patent database, TCM compound registry file and Shanghai TCM non-patent literature database, combining modern structure –biology technology and drug design technology, a research group has found a new way to design a new TCM recipe that may prevent and treat H1N1 virus infection.

36. Thank you for your time and attention! Liu Yanhuai East Linden, Inc. Tel: 86-10-82074090 Fax:86-10-82074090 Cell: 86-13621196207 Email: lyh@eastlinden.com