1. The Eye in Systemic Disease

2. ● Numerous conditions have eye symptoms associated with them ● Different parts of the eye are associated with different syndrome

3. The Eye in Systemic Disease ● Structure of Talk: – Mind Map

4. Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Moveme nts Pupillary Abnormali ties Retinal vessel disease

5. Common Eye Problems Cataracts Eye

6. CATARACTS Metaboli c Other Systemic Diseases Drug Induced

7. CATARACTS Meta- bolic DM G6P D PFK D

8. CATARACTS Metaboli c Other Systemic Diseases Muscular Dystroph y Derma- titis NF 2

9. CATARACTS Metaboli c Other Systemic Diseases Drug Induced Steroids

10. Common Eye Problems Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Moveme nts Pupillary Abnormali ties Retinal vessel disease

11. Common Eye Problems Eye Uveitis

12. Systemic Dis & Syndromes Infections Infestations

13. Uveitis Systemic Dis & Syndromes

14. Uveitis Systemic Dis & Syndromes Sarcoi d Behce ts Reiter's Ank Spond Crohn's Dis UC JCA

15. Uveitis Sarcoi d Behce ts Reiter's Ank Spond Crohn's Dis UC JCA Polyarthritis Systemic Dis & Syndromes

16. Uveitis Sarcoi d Behce ts Reiter's Ank Spond Crohn's Dis UC JCA Systemic Dis & Syndromes

17. Uveitis Sarcoi d Behce ts Reiter's Ank Spond Crohn's Dis UC JCA Systemic Dis & Syndromes

18. Uveitis Sar- coid Beh- cets Reiter's Ank Spond UC JCA Sacro- iliitis (also spine) Systemic Dis & Syndromes Crohn's Dis UC JCA

19. Uveitis Sarcoi d Behce ts Urethritis Arthritis Systemic Dis & Syndromes Reiter's Ank Spond Crohn's Dis UC JCA

20. Uveitis Sarcoi d Behce ts Overreaction of Immune System Systemic Dis & Syndromes Reiter's Ank Spond Crohn's Dis UC JCA

21. Uveitis Sarcoi d Beh- cets Reiter's Ank Spond Crohn's Dis UC JCA oral ulcers Genital ulcers Skin Lesions Systemic Dis & Syndromes

22. Uveitis Sarcoi d Behce ts Reiter's Ank Spond Crohn's Dis UC JCA Granulomas Unknown Aetiology Systemic Dis & Syndromes

23. Uveitis Sarcoi d Behce ts Reiter's Ank Spond Crohn's Dis UC JCA Systemic Dis & Syndromes

24. Uveitis Systemic Dis & Syndrome s Infections Infestations

25. Uveitis Infections

26. TB Candida Herpes Zoster

27. Uveitis Systemic Dis & Syndrome s Infections Infestations

28. Uveitis Infestations

29. Toxoplasm osis Toxocariasi s Pneumocyst osis

30. Common Eye Problems Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Moveme nts Pupillary Abnormali ties Retinal vessel disease

31. Common Eye Problems Eye Abnorm Eye Movements

32. Common Eye Problems Abnorm Eye Movements CVA Aneurys m DM

33. Common Eye Problems Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Movements Pupillary Abnormali ties Retinal vessel disease

34. Common Eye Problems Eye CRAO

35. Source of Emboli

36. Common Eye Problems Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Movements Pupillary Abnormali ties Retinal vessel disease

37. Common Eye Problems Eye Retinal vessel disease

38. Retinal vessel disease Diabetes Mellitus Hypertension Hypercholes terolaemia

39. Retinal vessel disease Diabetes Mellitus

40. Diabetes Mellitus Background Retinopathy Pre-prolif Retionopa thy Proliferati ve Retinopat hy Maculopat hy

41. Diabetes Mellitus Background Retinopathy Pre-prolif Retionopa thy Proliferati ve Retinopat hy Maculopat hy

42. Background Retinopathy Dot Haemorrha ges Hard Exudates NORMAL eyesight -present in almost all who have had type 1 diabetes for 20 years -present in nearly 80 percent of those with type 2 disease for 20 years Micro- aneurysms

45. Diabetes Mellitus Backgrou nd Retinopat hy Pre-prolif Retionopa thy Proliferati ve Retinopat hy Maculopat hy

46. Diabetes Mellitus Pre-prolif Retinopat hy

47. Pre-prolif Retionopathy Cotton Wool Spots Venous Irregularity NORMAL EYESIGHT

50. Pre-prolif Retionopathy REFER! 50% of patients progress to proliferative retinopathy within 1-2 years

51. Diabetes Mellitus Backgrou nd Retinopat hy Pre-prolif Retionopa thy Proliferati ve Retinopat hy Maculopat hy

52. Diabetes Mellitus Proliferati ve Retinopat hy

53. Proliferative Retinopathy Neo- vascularisa tion NVD NVE NORMAL EYESIGHT, but threatened....

56. Proliferative Retinopathy REFER!

57. Diabetes Mellitus Backgrou nd Retinopat hy Pre-prolif Retino- pathy Proliferative Retinopathy Maculopat hy

58. Diabetes Mellitus Maculopathy

59. Early and Diffuse Severe and Ischaemi c EYESIGHT AFFECTED

62. Maculopathy REFER!

63. Retinal vessel disease Diabetes Mellitus Hyper- tension Hypercholes t- erolaemia

64. Retinal vessel disease Hyper- tension

65. Hypertension Grade I Grade II Grade III Grade IV

66. Hypertension Grade I Grade II Grade III Grade IV

67. Hypertension Grade I Grade II Grade III Grade IV

68. Hypertension Grade I Grade II Grade III Grade IV Haemo rr- hages Cotton Wool Spots

69. Hypertension Grade I Grade II Grade III Grade IV

70. Hypertension Grade I Grade II Grade III Grade IV Silver Wiring

71. Hypertension Grade I Grade II Grade III Grade IV A-V Nipping

72. Hypertension Grade I Grade II Grade III Grade IV Haemo rr- hages Cotton Wool Spots

73. Hypertension Grade I Grade II Grade III Grade IV Papill- oedem a

74. Retinal vessel disease Diabetes Mellitus Hyper- tension Hypercholest- erolaemia

75. Common Eye Problems Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Movements Pupillary Abnormali ties Retinal vessel disease

76. Common Eye Problems Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Movements Pupillary Abnormali ties Retinal vessel disease

77. Amaurosis Fugax = painless, transient (secs/ mins), partial or complete

78. Amaurosis Fugax Embolic Vasospasti c/ Haemodyn amic Neourol ogic Ocular Idiopathi c

79. Amaurosis Fugax Embolic Vasospasti c/ Haemodyn amic Neuro- logic Ocular Idiopathi c Optic Neuritis (MS) Migraine

80. Amaurosis Fugax Embolic Vasospasti c/ Haemodyn amic Neourol ogic Ocular Idiopathi c TIA (cardiac/ carotid/ other)

81. Amaurosis Fugax Embolic Vasospastic/ Haemo- dynamic Neuro- logic Ocular Idio- pathic Temp Arteritis

82. Common Eye Problems Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Movements Pupillary Abnormali ties Retinal vessel disease

83. Common Eye Problems Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Movements Pupillary Abnormali ties Retinal vessel disease

84. Pupillary Defects Horner's Syndrom e CVA/SO L Adie’s Pupil

85. Common Eye Problems Eye Amauros is Fugax CRAO Uveitis Cataracts Abnorm Eye Movements Pupillary Abnormali ties Retinal vessel disease