1. Single-biomolecule Circuits With Carbon Nanotube Wiring Brett Goldsmith Collins Lab Department of Physics and Astronomy John Coroneus and Greg Weiss Department of Molecular Biology and Biochemistry

2. Overview: Creating a single-biomolecule circuit Device Preparation Electrically Measured Reactions First: Redox Reactions Second: Selective Reaction Third: Proteins

3. PMMA/PEG Source Drain Nanotube Devices R = 3M 

4. Electrochemical Oxidation of Nanotubes Mannik et al. PRL (2006) Goldsmith el al. Science (2007)

5. Oxidation Dynamics localization: session W26

6. Electrochemical Reduction of Nanotubes

7. Production of Carboxyl Groups by KMnO4 Goldsmith el al. Science (2007)

8. Selective Chemistry of Nanotubes functionalized nanotube in: buffer buffer with 10  M EDC

9. Protein Attached Circuits: Streptavidin Goldsmith el al. Science (2007)

10. Protein Attached Circuits: Lysozyme functionalized nanotube in: buffer buffer with enzyme substrate

11. Protein Attached Circuits: Lysozyme Enzyme without substrate Enzyme with substrate 360 420

12. Summary Dr. Phil Collins Brett Goldsmith Alex Kane Bucky Khalap Steve Hunt Danny Wan ACS-PRF Electrically Measured Reactions First: Redox Reactions Second: Selective Reaction Third: Proteins