3. Components of Blood Whole blood –RBCs –WBCs –Platelets: cell fragments that aid in clotting Plasma –90% water (allows materials to dissolve) –Amino acids, glucose, hormones, vitamins, salts, waste –Concentrations allows diffusion in/out of blood stream

4. Platelets Job: Help form clots to stop bleeding Proteins form a web to trap cells & platelets

5. White Blood Cells Remove foreign invaders & dead cells Able to move through body tissue

6. Red Blood Cells Produced from stem cells in bone marrow Lose nucleus as they mature Transport O 2 to cells; remove CO 2 O 2 binds to hemoglobin proteins Dead cells filtered by liver & spleen

7. NormalSickle Cell

8. Antigens: –Proteins on RBC’s that determine your blood type –Help to identify cells as foreign or natural –Analogy: Antigens are like jersey’s Antibodies: –Part of your immune system –Float freely in plasma –Job: attack foreign antigens ABO Blood Groups

9. Group A blood A antigens on the surface of your RBCs B antibodies in your plasma –only attack invaders with B antigens What would happen if a virus with B antigens entered your blood? Your B antibodies will attack and kill this virus. B antibody Vein

10. Group B blood B antigens on the surface of your RBCs A antibodies in your blood plasma –only attack invaders with A antigens What would happen if you gave this person type A blood? Their A antibodies would attack the donated blood. This person would die. A antibody Vein

11. Group AB blood Both A & B antigens on the surface of RBCs Neither A or B antibodies in your blood plasma What would happen if you gave this person type A blood? Nothing bad would happen. They have no antibodies to attack this blood. What would happen if you gave this person type B blood? Nothing bad would happen. They have no antibodies to attack this blood. Vein

12. Group O blood Neither A or B antigens on the surface of your RBCs Both A & B antibodies in your plasma –will attack invaders with A or B antigens B antibody What would happen if you gave this person type A blood? The A antibodies will attack. This person will die. A antibody Vein

13. Group O blood Neither A or B antigens on the surface of your RBCs Both A & B antibodies in your plasma –will attack invaders with A or B antigens What would happen if you gave this person type B blood? The B antibodies will attack. This person will die. A antibody B antibody Vein

14. Group O blood Neither A or B antigens on the surface of your RBCs Both A & B antibodies in your plasma –will attack invaders with A or B antigens What would happen if you gave this person type AB blood? The A and B antibodies will attack. This person will die. A antibody B antibody Vein

15. If you have type A blood, can you receive: Type A blood? Type B blood? Type AB blood? Type O blood? B antibodies will attack any blood with B antigens. No Yes No Yes

16. If you have type B blood, can you receive: Type B blood? Type A blood? Type AB blood? Type O blood? A antibodies will attack any blood with A antigens. Yes No Yes

17. If you have type AB blood, can you receive: Type AB blood? Type A blood? Type B blood? Type O blood? They have neither A nor B antibodies. Yes

18. If you have type O blood, can you receive: Type O blood? Type A blood? Type B blood? Type AB blood? A antibodies will attack any blood with A antigens. B antibodies will attack any blood with B antigens. No Yes

21. Rh Factors If Rh+ –Cells contain the Rh antigen (jersey) –Don’t contain Rh antibody –Can receive + or - blood If Rh- –Cells lack the Rh antigen, but… –Contains Rh antibody –Only receive Rh- blood

22. Blood type B+ Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh Practice problem

23. Blood type AB+ Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh Practice problem

24. Blood type O+ Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh Practice problem

25. Blood type AB- Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh Practice problem

26. Blood type O- Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh Practice problem

27. Francis was just in a bad accident and lost a lot of blood. He is blood type B+. Can you help save him?

28. Blood type B+ Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

29. Will his antibodies attack this blood? No. Can he receive B+ blood? Yes. A antibody Francis has B+ blood type because of the B and Rh antigens. If he is given B+ blood in a transfusion… Vein Key Point: A antibodies only attack A antigens

30. Francis has B+ blood type because of the B and Rh antigens. If he is given B- blood in a transfusion… A antibody Will his antibodies attack this blood? No. Can he receive B- blood? Yes. Vein Key Point: A antibodies only attack A antigens

31. Francis has B+ blood type because of the B and Rh antigens. If he is given A+ blood in a transfusion… Will his antibodies attack this blood? Yes. Can he receive A+ blood? No. A antibody Vein Agglutination: clumping of the blood Key Point: A antibodies only attack A antigens

32. Francis has B+ blood type because of the B and Rh antigens. If he is given A- blood in a transfusion… Will his antibodies attack this blood? Yes. Can he receive A- blood? No. A a n t i b o d y A a n t i b o d y A a n t i b o d y Vein Agglutination: clumping of the blood Key Point: A antibodies only attack A antigens

33. Francis has B+ blood type because of the B and Rh antigens. If he is given AB+ blood in a transfusion… Will his antibodies attack this blood? Yes. Can he receive AB+ blood? No. A antibody Vein Agglutination: clumping of the blood Key Point: A antibodies only attack A antigens

34. Francis has B+ blood type because of the B and Rh antigens. If he is given AB- blood in a transfusion… Will his antibodies attack this blood? Yes. Can he receive AB- blood? No. A a n t i b o d y A a n t i b o d y A a n t i b o d y Vein Agglutination: clumping of the blood Key Point: A antibodies only attack A antigens

35. Francis has B+ blood type because of the B and Rh antigens. If he is given O+ blood in a transfusion… Will his antibodies attack this blood? No. Can he receive O+ blood? Yes. A antibody Key Point: A antibodies only attack A antigens Vein

36. Francis has B+ blood type because of the B and Rh antigens. If he is given O- blood in a transfusion… A antibody Will his antibodies attack this blood? No. Can he receive O- blood? Yes. Vein Key Point: A antibodies only attack A antigens

37. Blood Type Internet Lesson

38. Sebastian was just involved in an accident at work and lost a lot of blood. He is blood type A-. Can you help save him?

39. Blood type A- Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

40. Sebastian has A- blood type because of the A antigen. If he is given A- blood in a transfusion… Will his antibodies attack this blood? No. Can he receive A- blood? Yes. B antibody Rh antibody B antibody Rh antibody B antibody Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Vein

41. Sebastian has A- blood type because of the A antigen. If he is given A+ blood in a transfusion… B antibody Will his antibodies attack this blood? Yes. But only the Rh antibodies will attack. Can he receive A+ blood? No. B antibody Rh antibody Vein Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens

42. Sebastian has A- blood type because of the A antigen. If he is given B- blood in a transfusion… Rh antibody Will his antibodies attack this blood? Yes. But only the B antibodies will attack. Can he receive B- blood? No. Rh antibody B antibody Vein Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens

43. Sebastian has A- blood type because of the A antigen. If he is given B+ blood in a transfusion… Will his antibodies attack this blood? Yes. Can he receive B+ blood? No. B antibody Rh antibody B antibody Rh antibody B antibody Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Vein

44. Sebastian has A- blood type because of the A antigen. If he is given AB- blood in a transfusion… Rh antibody Will his antibodies attack this blood? Yes. But only the B antibodies attack. Can he receive AB- blood? No. Rh antibody B antibody Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Vein

45. Sebastian has A- blood type because of the A antigen. If he is given AB+ blood in a transfusion… Will his antibodies attack this blood? Yes. Can he receive AB+ blood? No. B antibody Rh antibody B antibody Rh antibody B antibody Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Vein

46. Sebastian has A- blood type because of the A antigen. If he is given O+ blood in a transfusion… B antibody Will his antibodies attack this blood? Yes. But only the Rh antibodies will attack. Can he receive O+ blood? No. B antibody Rh antibody Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Vein

47. Sebastian has A- blood type because of the A antigen. If he is given O- blood in a transfusion… B antibody Rh antibody B antibody Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive O- blood? Yes. Rh antibody B antibody Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Vein

48. Review 1)What are the components found inside blood? 2)What are the ingredients of plasma? 3)What is the purpose/function of RBCs? 4)Which part of blood stop bleeding when cut? 5)What do antibodies bind with? 6)If a person has type AB-, which antigens do they possess? Which antibodies? 7)If a person has type O+, which antigens do they possess? Which antibodies? 8)If a person is type A-, list all the blood types this person can receive in a transfusion. 9)If a person is type O-, list all the blood types this person can receive in a transfusion.