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3.  NT  chemical messengers  Examples:  dopamine  norepinephrine  GABA  serotonin  melatonin

4.  Symptoms of clinical depression  change in sleep habits  loss of interest  irritability, tension, sadness  lack of energy  http://www.depression.com/depression_animation.html ?content=understanding& http://www.depression.com/depression_animation.html ?content=understanding&  Associated conditions  anxiety, panic attacks  bipolar disorder  OCD

5.  Brand NameGeneric Name Celexa*citalopram Lexaproescitalopram Paxil*paroxetine Prozac*fluoxetine Zoloft*sertraline *available as generics

6.  Time to take effect  Common side effects  nausea  insomnia  loss of appetite  sexual dysfunction  “Serotonin Syndrome”

7.  Brand NameGeneric Name Cymbaltaduloxetine Effexor*venlafaxine Effexor XRvenlafaxine, extended release Pristiqdesvenlafaxine *venlafaxine tablets are available in both regular release & extended release

8.  Time to take effect  Side effect profile similar to SSRIs  Serotonin Syndrome

9.  Brand NameGeneric Name Elavilamitriptyline Pamelornortriptyline Tofranilimipramine

10.  Common Side Effects  Drowsiness/Dizziness  Dry mouth  Constipation  Sexual dysfunction

11.  Brand NameGeneric Name Buspar*buspirone Desyrel*trazodone Remeron *mirtazapine Stratteraatomoxetine Wellbutrin*, bupropion Wellbutrin XL*,bupropion, ext release (qd) Wellbutrin SR*bupropion, sust. release (bid)

12.  buspirone – augments serotonin levels  trazodone – sleep  atomoxetine – norepinephrine reuptake inhibitor  bupropion –  No sexual side effects  Lowers seizure threshold  Various forms available (regular release tabs, extended release tabs, sustained release tabs)

13.  Black Box Warning  Abrupt Discontinuation Syndrome  Interaction with MAOIs

14.  Brand NameGeneric Name Ativanlorazepam Klonopinclonazepam Restoriltemazepam Valiumdiazepam Xanaxalprazolam

15.  Drowsiness  Impair judgement  Respiratory depression  Increased risk of falls in the elderly  Controlled substances = highly addictive

16.  Brand NameGeneric Name Ambien, Ambien Crzolpidem Lunestaeszopiclone