1. Efficacy and safety: check...by using the right sensor solution Bram Stelt – Large Account Manager Booth: 551 Cell: +31(0) 6 2117 7287 bram@exergenglobal.com www.exergenglobal.com

2. Requests from the market: -Increased speed -Increased quality -Guaranteed safety Downside: -Same or less budget -More challenging conditions TRENDS

3. SOME EXAMPLES Picture: blood analysisPicture: digital printing Video: WeldingVideo: Flash CureWeldingFlash Cure

4. The right sensor - simply not enough Innovative sensor technology Smart mechanical engineering teams and In depth know how of thermal processes APPROACH

5. SENSORANICS METHODOLOGY

6. SENSOR BY DESIGN………………THE PROCESS

7. Velashape II CASE STUDY – COSMETIC INDUSTRY

8. Potential Market for Fat Destruction Procedures In a survey of 1,045 women in NA 56% indicated interest in non-invasive fat destruction procedures Total Addressable Market in the US: 19.5M Patients World Market: $2b by 2017 ($ 700 mio in the US - Globaldata) MARKET SIZE

9. Survey Takeaway: “Pain-free with no downtime, it’s effective and totally believable.” “Over 75% of patients come in to my office and immediately ask “How much is it going to hurt?" PAIN FREE TREATMENT - SAFETY

10. PRINCIPLE OF OPERATION

11. OBJECTIVE

12. Next generation Velashape: -Pain free treatments -More efficient treatment -No downtime. Request -Non contact temperature sensor integrated in applicator for skin temperature monitoring -Closed loop RF mechanism to ensure reaching the set-point skin temperature for optimal treatment efficacy, and NOT exceed the set-point temperature for patient safety and comfort. OBJECTIVE SYNERON

13. Our challenges: -Size – very limited space available -Direct IR lamp interference -Field of view – lens -Ambient temperature fluctuations -Gel applied on skin: thermal gradient. CHALLENGES

14. Solution: Sensor selection: -Small size -Thermocouple compatible -Unpowered -No drift -High accuracy -High repeatibility -High interchangeability. OUR CHALLENGE: SIZE – VERY LIMITED SPACE AVAILABLE

15. Direct influence from IR lamps: immediate sensor response when IR lamps were switched on – measurement error of approx 3C. OUR CHALLENGE: DIRECT IR LAMP INTERFERENCE

16. Inner copper shroud blocking IR lamp radiation. Inner surface of shroud must be very low emissivity, otherwise the temperature of the shroud itself is measured. SOLUTION: DIRECT IR LAMP INTERFERENCE

17. OUR CHALLENGE: FIELD OF VIEW - LENS

18. SOLUTION: FIELD OF VIEW

20. No Power Required T/C Compatible Compensates for the Ambient Temperature AMBIENT TEMPERATURE COMPENSATION

21. ZnSe lens and window are not 100% transparent for IR radiation – some signal is absorbed: Sensor spectral response: 5.5 – 20 µm OUR CHALLENGE: BIG AMBIENT TEMPERATURE FLUCTUATIONS

22. The thermopile detector is responsive to the net power that it absorbs: P = σ * A * (Tt 4 - Ta 4 ) The Stefan-Boltzmann equation where: -P = net radiation power -A = surface area -Tt = target temperature -Ta = detector temperature. Since the detector absorbs power at σ * A * (Tt 4 ) and re-radiates power at its own temperature, the σ * A * (- Ta 4 ) term is needed. Tt is attenuated by the additional lens and window attenuate Ta is unchanged: ambient compensation error OUR CHALLENGE: BIG AMBIENT TEMPERATURE FLUCTUATIONS

23. 1)Sensor thermally isolated: slower heat up and more uniform heating 2)Additional thermocouple to measure sensor housing temperature to allow accurate ambient temperature compensation 1. 1: solution that is provided to Syneron is under NDA and can not be disclosed here. The example given here is more general in nature but covers the concept SOLUTION: BIG AMBIENT TEMPERATURE FLUCTUATIONS

24. mVo mV TC SOLUTION: BIG AMBIENT TEMPERATURE FLUCTUATIONS

25. OUR CHALLENGE: GEL ON SKIN – THERMAL GRADIENT. SOLUTION: HEAT BALANCE

26. The results for Tt=24C and Tt=59C. - IRt/c = Initial temp. in degC, - t/c = additonal t/c temp in degC, - Corrected: with ambient temperature compensation - Scaled: with heat balance. RESULTS

27. VelaShape III Advantages Increased RF Power: - End point temperature is achieved much faster - Reduction in treatment time - Consistent, reproducible resultst Sophisticated Feedback Mechanisms: - New closed loop RF mechanism and built in temperature sensor - Better monitoring for elevated temperature in the tissue - Increased patient comfort and safety Movie Syneron Velashape

28. Two important items I would like you to walk away with: 1. Market is very demanding and keeps on challenging the industry 2. There is always a solution if the thermal process is thoroughly understood – sensor by design. TO TAKE HOME

29. THANK YOU – TIME FOR ? Bram Stelt – Large accountmanager Booth: 551 Cell: +31(0) 6 2117 7287 bram@exergenglobal.com www.exergenglobal.com www.sensoranics.com