1. Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial Recruitment Christiana Hall, MD, MS Katrina van de Bruinhorst, MA

3. Enrolling Sites Cincinnati – University Hospital Emory – Grady Memorial GHSU Kentucky – University of Kentucky Maryland – University of Maryland Mayo Jacksonville MCW – Froedtert Memorial NYP – Columbia – Cornell Penn State Stanford – Stanford Temple – Allegheny General – Jefferson – Temple University UCSF – San Francisco General UPenn – Hospital of UPenn UT Houston – Memorial Hermann University of Utah UVA Wayne State – Beaumont Royal Oak WVU As of October 2012, 21 sites released to enroll

4. As of October 2012, 43 enrolled subjects

5. Sites Not Yet Released to Enroll Arizona Baylor Emory University – Emory University Hospital – Emory University Hospital Midtown HFHS – Henry Ford Hospital – Henry Ford West Bloomfield – University of Michigan MCW – Aurora-St. Lukes – Columbia St. Mary's – Mercy Hospital St. Louis – Loyola Minnesota ₋UMMC, Fairview ₋Hennepin County Medical Center OHSU – Harborview – UW Medical Center Temple – Hackensack University Medical Center – Hahnemann University Hospital UCSF ₋CPMC, Pacific Campus ₋CPMC, Davies Campus ₋UCSF UPenn ₋York Hospital ₋Abington Memorial ₋Rhode Island Hospital UT Houston ₋Austin UMC Brackenridge ₋Austin Seton UT Southwestern VCU Wayne State University ₋Beaumont Troy ₋Detroit Receiving ₋Sinai-Grace ₋St. John ₋Harper University

7. Preparing for Site Enrollment Establish enrollment estimates with recruitment team Identify date for readiness call