1. Accessible Syringe Dosing Jeff DeLorme Elese Hanson Christine Weisshaar Andrew Wentland Advisor : Willis Tompkins

2. University of Wisconsin - Madison Biomedical Engineering Design Courses INTELLECTUAL PROPERTY STATEMENT INTELLECTUAL PROPERTY STATEMENT All information provided by individuals or Design Project Groups during this or subsequent presentations is the property of the researchers presenting this information. In addition, any information provided herein may include results sponsored by and provided to a member company of the Biomedical Engineering Student Design Consortium (SDC). All information provided by individuals or Design Project Groups during this or subsequent presentations is the property of the researchers presenting this information. In addition, any information provided herein may include results sponsored by and provided to a member company of the Biomedical Engineering Student Design Consortium (SDC). Anyone to whom this information is disclosed: 1) Agrees to use this information solely for purposes related to this review; 2) Agrees not to use this information for any other purpose unless given written approval in advance by the Project Group, the Client / SDC, and the Advisor. 3) Agrees to keep this information in confidence until the relevant parties listed in Part (2) above have evaluated and secured any applicable intellectual property rights in this information. 4) Continued attendance at this presentation constitutes compliance with this agreement.

3. Overview Aim Aim Background/Motivation Background/Motivation Current syringe devices Current syringe devices Problem statement Problem statement Design alternatives Design alternatives Future plans Future plans Questions Questions

4. National Student Design Competition Aim Aim Design a low-cost and easy-to-use automated syringe dosing device Design a low-cost and easy-to-use automated syringe dosing device To accommodate a standard 1 cc syringe; ¼” diameter To accommodate a standard 1 cc syringe; ¼” diameter To be accurate to 0.01 cc To be accurate to 0.01 cc Designed for individuals with Designed for individuals with Type-2 Diabetes Type-2 Diabetes Parkinson’s and other neuromuscular disorders Parkinson’s and other neuromuscular disorders Poor vision Poor vision

5. Background/Motivation Diabetes patients use syringes on a daily basis to inject insulin Diabetes patients use syringes on a daily basis to inject insulin For diabetes patients with vision problems and neuromuscular disorders For diabetes patients with vision problems and neuromuscular disorders It becomes difficult to It becomes difficult to read the volume of fluid on the syringe read the volume of fluid on the syringe set the syringe’s plunger to the correct dosage set the syringe’s plunger to the correct dosage draw the plunger at a steady rate (preventing air bubbles) draw the plunger at a steady rate (preventing air bubbles)

6. Current products Insulin pumps Insulin pumps Costly (~$5000) Costly (~$5000) Must be worn constantly Must be worn constantly Autoject2 ® -Owen Mumford Autoject2 ® -Owen Mumford Assists in injecting, not dosing Assists in injecting, not dosing

7. Problem Statement To develop a syringe delivery device that can: To develop a syringe delivery device that can: Draw insulin to a specific dosage Draw insulin to a specific dosage Minimize the need for fine motor control Minimize the need for fine motor control Control the rate of insulin influx Control the rate of insulin influx Assist in universal design Assist in universal design Visual and auditory cues Visual and auditory cues

8. Variations of the Device Design Approaches TabletopPortable

9. Tabletop Approach Procedure User inserts syringe and insulin bottle into a tabletop device User inserts syringe and insulin bottle into a tabletop device User inputs the quantity of insulin needed through a keypad component User inputs the quantity of insulin needed through a keypad component Device fills syringe with desired amount of insulin Device fills syringe with desired amount of insulin User removes syringe and administers insulin User removes syringe and administers insulin Pros and Cons Automates measuring and drawing of the insulin Automates measuring and drawing of the insulin Not portable or convenient Not portable or convenient

10. Handheld Approach Procedure User inputs syringe into device and inputs desired amount of insulin using a keypad User inputs syringe into device and inputs desired amount of insulin using a keypad User inserts syringe into insulin bottle User inserts syringe into insulin bottle Device pulls back plunger to desired amount Device pulls back plunger to desired amount User removes syringe and inserts the needle into adipose User removes syringe and inserts the needle into adipose Device administers insulin by pushing plunger Device administers insulin by pushing plunger Pros and Cons Automates drawing, measuring, and administering medication Automates drawing, measuring, and administering medication Handheld and portable Handheld and portable Doesn’t assist in handling the insulin bottle Doesn’t assist in handling the insulin bottle

11. Mechanisms of the Device The Handheld Device Hydraulics Driven Motor/Screw Driven

12. Hydraulics- Driven

13. Motor/Screw-Driven

14. Motor/Screw-Driven

15. Future plans Finalize the design Finalize the design Obtain parts Obtain parts Begin construction and instrumentation Begin construction and instrumentation Test accuracy and ease of use Test accuracy and ease of use

16. QUESTIONS??

17. Design matrix HandheldTabletop Portability13 Cost12 Ease of Use11 Accuracy11 Total47 1 = good. 2 = medium. 3 = poor.

18. Design matrix Hydraulics-DrivenMotor/Screw-Driven Cost32 Simplicity21 Reliability21 Size21 Strength12 Total107 1 = good. 2 = medium. 3 = poor.