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Biodegradable Poly-d,l-Lactic Acid-Polyethylene Glycol Block Copolymers as a BMP Delivery System for Inducing Bone by Naoto Saito, Takao Okada, Hiroshi.

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Presentation on theme: "Biodegradable Poly-d,l-Lactic Acid-Polyethylene Glycol Block Copolymers as a BMP Delivery System for Inducing Bone by Naoto Saito, Takao Okada, Hiroshi."— Presentation transcript:

1 Biodegradable Poly-d,l-Lactic Acid-Polyethylene Glycol Block Copolymers as a BMP Delivery System for Inducing Bone by Naoto Saito, Takao Okada, Hiroshi Horiuchi, Narumichi Murakami, Jun Takahashi, Masashi Nawata, Hiroshi Ota, Shimpei Miyamoto, Kazutoshi Nozaki, and Kunio Takaoka J Bone Joint Surg Am Volume 83(1 suppl 2):S92-S98 April 1, 2001 ©2001 by The Journal of Bone and Joint Surgery, Inc.

2 Fig. 1: A: Structural formula of poly-d,l-lactic acid homopolymer (PLA). m: number of units. Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98 ©2001 by The Journal of Bone and Joint Surgery, Inc.

3 Fig. 1: A: Structural formula of poly-d,l-lactic acid homopolymer (PLA). m: number of units. Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98 ©2001 by The Journal of Bone and Joint Surgery, Inc.

4 Classification of six types of poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA-PEG) with plastic properties into four groups according to the calculated molecular weight of the PLA segment and PEG segment. Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98 ©2001 by The Journal of Bone and Joint Surgery, Inc.

5 Fig. 3: A and B: A soft radiograph and light micrograph of the new bone formed 3 weeks after implantation in the poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA6,500- PEG3,000) implant with 10 g of recombinant human bone morphogenetic protein (... Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98 ©2001 by The Journal of Bone and Joint Surgery, Inc.

6 Fig. 3: A and B: A soft radiograph and light micrograph of the new bone formed 3 weeks after implantation in the poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA6,500- PEG3,000) implant with 10 g of recombinant human bone morphogenetic protein (... Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98 ©2001 by The Journal of Bone and Joint Surgery, Inc.

7 Fig. 4: A and B: The swelling characteristic of the poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA6,500-PEG3,000) is thought to be beneficial when considering the practical application of polymer/bone morphogenetic protein (BMP) composites to... Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98 ©2001 by The Journal of Bone and Joint Surgery, Inc.

8 Fig. 4: A and B: The swelling characteristic of the poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA6,500-PEG3,000) is thought to be beneficial when considering the practical application of polymer/bone morphogenetic protein (BMP) composites to... Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98 ©2001 by The Journal of Bone and Joint Surgery, Inc.

9 An example of bone induction on the surface of a block of porous hydroxyapatite (HA) combined with bone morphogenetic protein-2 and the plastic and swelling carrier polymer. Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98 ©2001 by The Journal of Bone and Joint Surgery, Inc.

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