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Published byHugh Warren Modified over 9 years ago
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Macromolecules Building Complex Molecules That Comprise Living Things
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Organic Macromolecules Contain Carbon Therefore, each carbon atom can make ____ covalent bonds with other types of atoms or additional carbons. Question: How many electrons does carbon need to fill its outer energy level? Answer: Four four
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In a double bond, carbons share two pairs of electrons In a triple bond, carbons share three pairs of electrons
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Carbon Atoms Bind to Functional Groups
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Organic Molecules Can Exist as Isomers Structural Isomers have the same atoms in different bonding relationships Stereoisomers have different spatial positioning for the same bonding relationships cis-trans isomers enantiomers
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Macromolecules: Polymers Made of Repeating Monomers Macromolecule Monomer Unit CarbohydratesSugars Lipids Fatty acids Proteins Amino acids Nucleic Acids Nucleotides
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Synthesis and Breakdown of Macromolecules Condensation or Dehydration Synthesis Removal of water to add monomer units Hydrolysis Addition of OH and H groups of water to break a bond between monomers
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Dehydration Synthesis / Hydrolysis Dehydration Synthesis Hydrolysis
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Nucleic Acid Structure and Function
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DNA RNA Protein Information Flow From DNA transcription translation replication (prior to cell division) (ongoing cellular metabolism) Gene: sequence of DNA that codes for a protein
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DNA and RNA Structure DNA DNA RNA RNA Primary Structure Chain of nucleotides Secondary Structure Double helix Single folded chain
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Three Parts of Nucleotide Structure Nitrogenous Base (1 of 5) CH 2 HH Deoxyribose or Ribose OO HH OHOHHH HH HH OH HOP O O 5-Carbon Sugar Phosphate Group NN HCHC NN CC CC CC CHCH NN NN NH 2
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DNA and RNA Structure DNA RNA RNA Purine bases Adenine (A) Guanine (G) Adenine (A) Guanine (G) Pyrimidine bases Cytosine (C) Thymine (T) Cytosine (C) Uracil (U) 5-carbon sugar deoxyriboseribose Phosphate PO 4 PO 4 OHOH OHH
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Nucleotide Chain Nucleotides are joined together by dehydration synthesis Nucleotides are joined together by dehydration synthesis The phosphate of one nucleotide is joined to sugar of next nucleotide, forming a “sugar-phosphate backbone” The phosphate of one nucleotide is joined to sugar of next nucleotide, forming a “sugar-phosphate backbone”
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DNA Structure Two nucleotide chainsTwo nucleotide chains In opposite orientationsIn opposite orientations Held together by hydrogen bondsHeld together by hydrogen bonds Twisted into a helixTwisted into a helix G A C A C T G T A T T A 5’ end has free phosphate 3’ end has free sugar 3’ end 5’ end A pairs with T G pairs with C
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T A CG
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DNA Secondary Structure The Double Helix Two polynucleotide chains are wound togetherTwo polynucleotide chains are wound together Bases are located inside the helixBases are located inside the helix Sugar-phosphate groups are on the outside as a “backbone”Sugar-phosphate groups are on the outside as a “backbone” Bases are arranged like rungs on a ladder, perpendicular to the “backbone”Bases are arranged like rungs on a ladder, perpendicular to the “backbone” 10 base pairs per turn of the helix10 base pairs per turn of the helix
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DNA Replication DNA chains separateDNA chains separate Each chain is used as a pattern to produce a new chainEach chain is used as a pattern to produce a new chain Each new DNA helix contains one “old” and one “new” chainEach new DNA helix contains one “old” and one “new” chain
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Transcription = Production of RNA Using DNA as a Template DNA chains separateDNA chains separate ONE DNA chain is used as a pattern to produce an RNA chainONE DNA chain is used as a pattern to produce an RNA chain RNA chain is released and the DNA chains reform the double-helixRNA chain is released and the DNA chains reform the double-helix In DNA In RNA A U T A G C C G
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RNA Secondary Structure Single, Folded Chain Each RNA has a unique structure based on its nucleotide sequenceEach RNA has a unique structure based on its nucleotide sequence RNA-RNA Base Pairing RulesRNA-RNA Base Pairing Rules –A pairs with U –G pairs with C Can linkCan link –bases in proximity –distant base sequences
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Functions of Nucleotides and Nucleic Acids DNA Hereditary Material, specifies protein sequences RNA Intermediate in protein production Ribozymes RNA catalysts ATP Energy transfer GTP Activator/Inhibitor in Signal Transduction cAMP (cyclic AMP) Secondary messenger in Signal Transduction
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