2. Charles Pallandt Regional Director Turkey, Middle East and Africa Tayfun Basal Sales Manager Turkey t.basal@elsevier.com Mob phone: 0 533 771 8689 Catching up with other hospital consortia in the world

3. 2 Agenda Introduction: Health Science market analysis. Current and future content on ScienceDirect: - Journals including Cell Press - Books Xpharm PharmaPendium

4. 3 Overall Market Share 2006 by Publishers

5. 4 Health Science Market Share 2006 by Publishers

6. 5 Elsevier – Market share (% papers published) in Health Science Harcourt acquisition Elsevier (3/4%) outperforms average market growth 2/3%)

7. 6 Health Science Summary by Publisher Influence (or Citation Share) - Indicates the share of citations that the publisher has. Citations have been measured over a five-year period (2001 - 2005).

8. 7 The impact of electronic acces: Turkey; accelerated output after universities were on Science Direct Source: Thomson Scientific (ISI) Article output 1996-2005 Turkish CAGR ( ’00-’05) : 25%

9. 8 Content on ScienceDirect today Backfiles pre 1995 ~4 million articles Book Series 145 titles Reference Works51 titles Handbooks 7 series 1995 - present ~3 million articles 2000 journals

10. 9 Contains > 2000 journals – Elsevier Science – Pergamon – North Holland – Academic Press – Harcourt Health Sciences – Cell Press – etc > 7.9 million full-text articles – 23 subjects – Articles In Press – Backfile articles back to Volume 1, Issue 1 Journals on ScienceDirect

11. 10 ScienceDirect Content - Journals

12. 11 All journals are available on ScienceDirect from volume 1, issue 1 The Lancet – vol 1, no. 1 - 1823.

13. 12 ScienceDirect Content – Cell Press Cell Press publishes prestigious highly- cited biomedical research journals Cell Neuron Immunity Molecular Cell Developmental Cell Cancer Cell Current Biology Structure Chemistry & Biology Cell Metabolism

14. 13 Cell The 2004 Nobel Prize in Physiology/Medicine awarded to Richard Axel, M.D., and Linda S. Buck, Ph.D., for their work studying the organization of the olfactory system was based on research published in their seminal 1991 Cell paper.

15. 14 ScienceDirect Content – Cell Press Ground-breaking articles from the Cell Press journals are now available at the desktop. Discovery 1984 Ubiquitin as central cellular regulator 2003 Gene required for stem cell pluripotency Knowledge 1979 Tyrosine phosphorylation 1989 Rag1 mediates antibody diversity Impact 1974 First cloning of eukaryotic gene 1994 Mechanisms of long-term memory

16. 15 Cell Press: High-impact journals available at the desktop Each Cell Press title is at or near the top of its ISI subject category. Cell – with a current Impact Factor of 27.254 according to the 2002 ISI Journal Citation Report – has been the top research journal in the cell biology and biochemistry and molecular biology categories six of the last seven years. Similar impressive statistics apply to Neuron and Immunity in their respective categories. Newer titles like Molecular Cell, Developmental Cell and Cancer Cell have quickly established themselves as top-tier journals within their respective communities.

17. 16 ScienceDirect Content – Online Books Reference Works/ Encyclopedia Handbooks (NEW) 51 Titles 7 series 164 volumes Book Series 7 packages 163 titles

18. 17 Why did libraries purchase books on ScienceDirect?* - Ease of use. - Cross Linking and searching across different type of content. - Simultaneous user access. - Remote access. - Quality of the Content. - Storage/cost saving: No more lost, damaged or multiple copies; saving shelf space. * 2006 Results from research with 5 university libraries worldwide conducted by an external agency

19. 18 Elsevier Book Series New volumes published regularly. Focus on ‘Advances in’ or ‘Progress in’ etc. Series ISSN, volume ISBNs. Peer-reviewed, often highly cited. 163 Series now available in 7 packages including: - Life Sciences - Psychology - Methods in Enzymology - Methods in Enzymology Backfiles from 1955

20. 19 Elsevier Book Series Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Now with over 400 volumes since 1955, the series contains much material still relevant today — truly an essential publication for researchers in all fields of life sciences. "The 'Methods in Enzymology' series represents the gold-standard." Neuroscience "Incomparably useful." Analytical Biochemistry "A series that has established itself as a definitive reference for biochemists." Journal of Chromatography

21. 20 Biomedical Method Research Title

22. 21 Elsevier Reference Works High quality reference material. Highly detailed and structured. Highly used and cited. 51 now available on ScienceDirect including: Encyclopedia of Cancer Encyclopedia of Endocrine Diseases Encyclopedia of Gastroenterology Encyclopedia of Hormones Encyclopedia of Human Nutrition Encyclopedia of Immunology Encyclopedia of the Neurological Sciences Encyclopedia of Toxicology Encyclopedia of Virology Encyclopedia of Biological Chemistry Meyler's Side effects on Drugs Encyclopedia of Genetics

23. 22 Elsevier Handbooks series Launched 7 series in Chemistry, Mathematics, Physics and Economics in 2005. Chapters by commissioning & invitation only. Validated, refereed and edited by authoritative editors Highly cited. Usually long life cycle – up to 15 years. Forthcoming in 2006 Handbooks of Neurology

24. 23 Forthcoming in August 2007 Over 4000 eBooks!

25. 24 2006 eBook Offer 10% discount: If you purchase any eBook before 30 th November 2006. Fill in your form. Fax back to +31 20 485 3042 or email: Tayfun Basal: t.basal@elsevier.com.

26. 25 Demonstration of ScienceDirect

27. 26 www.sciencedirect.com

28. 27 Find journals/books of interest.

29. 28 Find journals/books of interest. Option 2

30. 29 Find journals/books of interest

31. 30 Find journals/books of interest

32. 31 Find articles of interest

33. 32 Find journal of interest

34. 33 Find articles of interest

35. 34 Find articles of interest

36. 35 Searching – Quick search

37. 36 Searching – for more advanced features

38. 37 Searching

39. 38 Searching

40. 39 Example

41. 40 Example

42. 41 Usage statistics

43. 42 Overall ScienceDirect Usage 53 M 86 M 140 M 85 M 10 million regular users 36 full-text downloaded every second of a regular working day. 270 M

44. 43 Health Science Market Share 2006 by Publishers Science Direct usage is more than fair share!

45. 44 Usage statistics Available via http://usagereports.elsevier.com (Password protected)http://usagereports.elsevier.com

46. 45 Usage statistics

47. 46 ScienceDirect statistics

48. Presented by: Title: Date: xPharm A Pharmacological Reference Database for Life Scientists

49. 48 What is xPharm? And the mechanisms that govern their interaction An easily accessed, well thought through and highly functional repository of pharmacological information that quickly provides answers to in-depth pharmacology questions. Agents Targets Disorders Principles “xPharm is an exceptional resource – a one of a kind undertaking that is an encyclopedia of modern pharmacology” Howard Gendelman, M.D. Chair, Department of Pharmacology University of Nebraska

50. 49 Easy to use  Consistent color coding to orient the user  Easy Browsing from table of Contents  Support for basic and advanced queries alzheimer

51. 50 Detailed Classification and alternate names Pharmacological regulation Disease associations Assays xPharm displays more detailed information about pharmacologically relevant targets than any print and online source

52. 51 Extensive & Comprehensive  Genetic database  Protein database  Literature  Full-text articles  Additional supporting material, such as an ECG Library xPharm automatically links researchers to related sources of information

53. 52 Only relevant data is displayed Agent names are listed with associated targets that produce edema Binding data is displayed for targets implicated in schizophrenia All links to full records are preserved No need to sift through unwanted information

54. 53 Integrated with MDL Content Connect to related data in MDL databases for a comprehensive discovery picture

55. 54 Value comparison for the library Pharmacology Reference Work:(Goodman and Gilman)  More than 10X the printed page count of current ‘gold standard’ reference work in pharmacology Pharmacology Journal: Trends in Pharmacological Sciences  5-6 review articles per issue  66 articles per year xPharm  >3600 articles at purchase  Averaging > 300 new articles per year  All content written and edited by research scientists.  Approximately 550 contributing scientists from 21 different nations

56. The Essential Drug Safety Resource

57. 56 PharmaPendium  A single source web based system that allows a single search to retrieve Preclinical animal, Human clinical trial and Post-market safety data, and intelligent pathways to that data.

58. 57 Who would find this useful?  Preclinical Safety Teams  Toxicologists  ‘Discovery’ Toxicologists  Safety Pharmacologists  DMPK, ADME  Medicinal Chemists  Clinical Researchers  Regulatory Affairs

59. 58 PharmaPendium: Sources  3,000 Drugs covered  FDA Approval Packages  Preclinical, clinical  Meyler’s Side Effects of Drugs 15 th Edition  Major reference work  Package Insert information (Labels)  Drug Monographs: Current & Withdrawn after 1997  Toxicity/Metabolites extracted from literature.  Adverse Event Reporting System (AERS)  Post market  Drug/Target associations

60. 59 FDA Approval Package Database  US-approved drugs (1992 and later)  1400+ drugs with approval documents  700 with full Review sets (most 1992 and later); over 700 others with partial packages.  ~ 23,000 Documents  ~ 650,000 pages of information  ~ 300,000 extracted safety records  Preclinical & Clinical data extracted.  Full FDA reviews, label updates, warnings, etc.  Able to be navigated via text search, chemistry search, and browsed by target, drug, class.

61. 60 FDA Database: July Update  Update:  9,800 new searchable documents  204,000 new searchable pages.  After 1 st Update:  33,000 documents  850,000 pages

62. 61 FDA Database: July Update Free evaluations to all presented products for the coming 6 weeks: 1. Journals / e-books on Science Direct 2. Cell Press 3. Xpharm 4. PharmaPendium

63. 62 Thank you for your attention and enjoy trialling! Elsevier, Amsterdam, The Netherlands