Presentation is loading. Please wait.

Presentation is loading. Please wait.

HIV: Acute (Primary) Infection. David H

Published byNatalie Booth Modified over 9 years ago

Similar presentations

Presentation on theme: "HIV: Acute (Primary) Infection. David H"— Presentation transcript:

1 HIV: Acute (Primary) Infection. David H
HIV: Acute (Primary) Infection David H. Spach, MD Medical Director, Northwest AIDS Education and Training Center Associate Professor of Medicine,Division of Infectious Diseases University of Washington, Seattle Spach/HIV/Acute HIV/PP 1

2 Acute (Primary) HIV Spach/HIV/Acute HIV/PP 1

3 Spach/HIV/Acute HIV/PP
1

4 Case History A 27-year-old man presents with a 48 hour history of fever, lymphadenopathy, severe fatigue, and rash. He had high risk sexual activity with 2 other men 7 days ago. He has no known prior medical problems. Spach/HIV/Acute HIV/PP 1

5 Acute (Primary) HIV HIV Antibodies HIV RNA Acute HIV “Set Point”
3 months 6 months Spach/HIV/Acute HIV/PP 1

6 Acute HIV Early Events in Transmucosal Infection
From: Kahn J, Walker BD. N Engl J Med 1998;339:33-9. Spach/HIV/Acute HIV/PP 1

7 Case History: Question
A diagnosis of acute (primary) HIV is suspected. Which of the following best supports this diagnosis? 1) A negative HIV antibody test and HIV RNA 1,000 2) A negative HIV antibody test and HIV RNA 200,000 3) A positive HIV antibody test and HIV RNA of 2,000 4) A positive HIV antibody test and HIV RNA of 50,000 Spach/HIV/Acute HIV/PP 1

8 HIV: Manifestations of Primary Infection
From: Vanhems P. AIDS 2000;14:375. Spach/HIV/Acute HIV/PP 1

9 Acute (Primary) HIV HIV Antibodies HIV RNA “Set Point” 3 months
Spach/HIV/Acute HIV/PP 1

10 Plasma HIV RNA Levels Acute HIV “Set Point” 6 months
Spach/HIV/Acute HIV/PP 1

11 HIV Infection: Natural History
Acute HIV Infection Year 1 Spach/HIV/Acute HIV/PP 1

12 Risk of Progression to AIDS: HIV RNA & CD4
HIV RNA Level (bDNA) From: Mellors J et al. Science 1996;272: Spach/HIV/Acute HIV/PP 1

13 Immune Response to Acute HIV Infection
Weak CTL Rapid Progression Moderate CTL Moderate Progression Strong CTL Slow Progression 6 months From: Walker BD. Nature 2000;407:313-4. Spach/HIV/Acute HIV/PP 1

14 HIV Primary Infection Isolates
N = 108 Patients Newly HIV-Infected Phenotypic Data: 10-fold Resistance From: Little SJ. JAMA 1999;282: Little SJ. 8th Conf Retrovirus. Abstract 756 Spach/HIV/Acute HIV/PP 1

15 HIV Primary Infection Isolates
N = 141 Patients Phenotypic Data From: Little SJ. JAMA 1999;282: Spach/HIV/Acute HIV/PP 1

16 HIV Primary Infection Isolates
N = 80 Patients Genotypic Data From: Boden D. JAMA 1999;282: Spach/HIV/Acute HIV/PP 1

Download ppt "HIV: Acute (Primary) Infection. David H"

Similar presentations

Acute HIV and the North Carolina STAT Project

Acute HIV and the North Carolina STAT Project
Diagnosis and Management of Acute HIV Infection HIV Clinical Guidelines from the New York State Department of Health AIDS Institute January 2010 HIV CLINICAL.

Diagnosis and Management of Acute HIV Infection HIV Clinical Guidelines from the New York State Department of Health AIDS Institute January 2010 HIV CLINICAL.
Perspectives on Outreach from the NYC Department of Health and Mental Hygiene Benjamin Tsoi, MD, MPH Bureau of HIV/AIDS Prevention and Control NYC Department.

Perspectives on Outreach from the NYC Department of Health and Mental Hygiene Benjamin Tsoi, MD, MPH Bureau of HIV/AIDS Prevention and Control NYC Department.
Northwest Center for Public Health Practice University of Washington School of Public Health and Community Medicine 1 Preparing for and Responding to Bioterrorism:

Northwest Center for Public Health Practice University of Washington School of Public Health and Community Medicine 1 Preparing for and Responding to Bioterrorism:
Acute Retroviral Syndrome

Acute Retroviral Syndrome
Integrating Rapid HIV Testing in Emergency Care Improves HIV Detection Evan M. Cadoff, MD Robert Wood Johnson Medical School New Brunswick, NJ www.njhiv.org.

Integrating Rapid HIV Testing in Emergency Care Improves HIV Detection Evan M. Cadoff, MD Robert Wood Johnson Medical School New Brunswick, NJ
David H. Spach, MD Professor of Medicine Division of Infectious Diseases University of Washington, Seattle.

David H. Spach, MD Professor of Medicine Division of Infectious Diseases University of Washington, Seattle.
Routine HIV Screening in Health Care Settings David Spach, MD Clinical Director Northwest AIDS Education and Training Center Professor of Medicine, Division.

Routine HIV Screening in Health Care Settings David Spach, MD Clinical Director Northwest AIDS Education and Training Center Professor of Medicine, Division.
Routine HIV Screening in Health Care Settings David Spach, MD Clinical Director Northwest AIDS Education and Training Center Professor of Medicine, Division.

Routine HIV Screening in Health Care Settings David Spach, MD Clinical Director Northwest AIDS Education and Training Center Professor of Medicine, Division.
Initiating Antiretroviral Therapy in Treatment-Naive Patients Charles B. Hicks, MD Associate Professor of Medicine, Division of Infectious Diseases and.

Initiating Antiretroviral Therapy in Treatment-Naive Patients Charles B. Hicks, MD Associate Professor of Medicine, Division of Infectious Diseases and.
Primary HIV Infection Christopher Behrens, MD Northwest AIDS Education & Training Center University of Washington.

Primary HIV Infection Christopher Behrens, MD Northwest AIDS Education & Training Center University of Washington.
Acute HIV in North Carolina STD Clinics The North Carolina STAT Project Peter A. Leone, MD Associate Professor of Medicine University of North Carolina.

Acute HIV in North Carolina STD Clinics The North Carolina STAT Project Peter A. Leone, MD Associate Professor of Medicine University of North Carolina.
Slide 1 of 11 From CB Hicks, MD, at Chicago, IL: May 20, 2013, IAS-USA. IAS–USA Charles B. Hicks, MD Professor of Medicine Duke University Medical Center.

Slide 1 of 11 From CB Hicks, MD, at Chicago, IL: May 20, 2013, IAS-USA. IAS–USA Charles B. Hicks, MD Professor of Medicine Duke University Medical Center.
Routine HIV Screening in Health Care Settings David Spach, MD Clinical Director Northwest AIDS Education and Training Center Professor of Medicine, Division.

Routine HIV Screening in Health Care Settings David Spach, MD Clinical Director Northwest AIDS Education and Training Center Professor of Medicine, Division.
Ghassan Wahbeh MD Associate Professor, Director IBD Program Seattle Children’s Hospital University of Washington.

Ghassan Wahbeh MD Associate Professor, Director IBD Program Seattle Children’s Hospital University of Washington.
N ORTHWEST AIDS E DUCATION AND T RAINING C ENTER CROI 2015: What’s New in Hepatitis? Nina Kim, MD Associate Professor of Medicine Division of Allergy &

N ORTHWEST AIDS E DUCATION AND T RAINING C ENTER CROI 2015: What’s New in Hepatitis? Nina Kim, MD Associate Professor of Medicine Division of Allergy &
Hepatitis web study Hepatitis web study Peginterferon alfa-2b + RBV versus Interferon alfa-2b RIBAVIC STUDY Phase 3 Treatment Naïve, Chronic HCV and HIV.

Hepatitis web study Hepatitis web study Peginterferon alfa-2b + RBV versus Interferon alfa-2b RIBAVIC STUDY Phase 3 Treatment Naïve, Chronic HCV and HIV.
Salvage Antiretroviral Therapy Guiding Principles, Strategies and the Role of Resistance Testing.

Salvage Antiretroviral Therapy Guiding Principles, Strategies and the Role of Resistance Testing.
Initial Evaluation and Common Clinical Manifestations

Initial Evaluation and Common Clinical Manifestations
Current HIV basic science research topics. Toddler Functionally Cured of HIV Infection- “the Mississippi Baby” First well-documented case of an HIV.

Current HIV basic science research topics. Toddler "Functionally Cured" of HIV Infection- “the Mississippi Baby” First well-documented case of an HIV.

Similar presentations

Ads by Google