1. The Kidney your bodies blood filter

2. The Kidney  Ultrafiltration: filter the blood plasma through the glomerulus and fenestrated capillaries  Increase in blood pressure in the glomerulus drives the filtration process  The fenestrations (slits) open up as blood flows through at high pressure  The basement membrane is not permeable to larger molecules, preventing things like protein enter the filtrate

3. The Kidney  Osmoregulation is the homeostatic process of controlling water levels in all tissues in your body  Why is it necessary?  Regulating the water levels will allow blood cells to remain in tact

4. The Kidney  The kidney is almost too good at filtering your blood…  Much of what initially gets filtered out has to be returned  Most noteworthy substances to be reabsorbed: water, salts, glucose  If water wasn’t reabsorbed you’d be peeing a lot more!  Much of reabsorption occurs via osmosis and diffusion, some via active transport (needs ATP)

5. The Kidney

6.  With ADH NOT available, water stays in the filtrate/urine  With ADH present, water leaves, urine production decreases/becomes more concentrated

7. The Kidney  Diabetics can often have glucose in their urine  Not normal…typically 100% of glucose reabsorbed  Cotransport (active) of glucose against gradient has a capacity—too much glucose ends up in urine