1. 04.10 The Sodium-Potassium Pump
Slide number: 1
Extracellular
fluid with high
concentration
of Na+
Na+ K+
Na+
ATP
ADP P P K+
Cytoplasm
with high
concentration
of K+ P 1
Three Na+ bind to the
cytoplasmic side of the protein. 2
Phosphate is transferred from ATP to the protein. 3
Phosphorylation
changes the
shape of the
protein, moving
Na+ across the
membrane. 4
K+ binds to
the protein, causing
phosphate
release. 5
Release of
phosphate
changes the
shape of the
protein,
moving K+ to
the cytoplasm.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

2. 04.10 The Sodium-Potassium Pump
Slide number: 2
Extracellular
fluid with high
concentration
of Na+ 1
Three Na+ bind to the
cytoplasmic side of the protein.
Na+
Cytoplasm
with high
concentration
of K+
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

3. 04.10 The Sodium-Potassium Pump
Slide number: 3
Extracellular
fluid with high
concentration
of Na+ 1
Three Na+ bind to the
cytoplasmic side of the protein. 2
Phosphate is transferred from ATP to the protein.
ATP
ADP P
Cytoplasm
with high
concentration
of K+
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

4. 04.10 The Sodium-Potassium Pump
Slide number: 4
Extracellular
fluid with high
concentration
of Na+ 1
Three Na+ bind to the
cytoplasmic side of the protein. 2
Phosphate is transferred from ATP to the protein.
Na+ 3
Phosphorylation changes the shape of the protein, moving Na+ across the membrane. P
Cytoplasm
with high
concentration
of K+
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

5. 04.10 The Sodium-Potassium Pump
Slide number: 5
Extracellular
fluid with high
concentration
of Na+ 1
Three Na+ bind to the
cytoplasmic side of the protein. 2
Phosphate is transferred from ATP to the protein. K+ 3
Phosphorylation changes the shape of the protein, moving Na+ across the membrane. 4
K+ binds to the protein, causing phosphate release. P
Cytoplasm
with high
concentration
of K+
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

6. 04.10 The Sodium-Potassium Pump
Slide number: 6
Extracellular
fluid with high
concentration
of Na+ 1
Three Na+ bind to the
cytoplasmic side of the protein. 2
Phosphate is transferred from ATP to the protein. 3
Phosphorylation changes the shape of the protein, moving Na+ across the membrane. 4
K+ binds to the protein, causing phosphate release. K+ 5
Release of phosphate changes the shape of the protein, moving K+ to the cytoplasm.
Cytoplasm
with high
concentration
of K+
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.