1. © Copyright 2002 Frost & Sullivan. All Rights Reserved. U.S. Hyaluronic Acid-Based Biomaterials Markets Growing Health Needs of the Elderly Spur Demand for New Biomaterial Therapies “Although collagen-based products have been on the market for a long time, HA-based products are expected to displace them in many applications.” Pharmaceuticals Analyst Team Frost & Sullivan

2. © Copyright 2002 Frost & Sullivan. All Rights Reserved. Frost & Sullivan provides: Detailed insights into recent developments and trends Drivers, restraints, challenges, and strategic recommendations Analyst insights on ‘hot topics’ and emerging applications in the Hyaluronic acid-based biomaterials markets Market sizing and competitive analysis Market forecasts and opportunity analysis Quarterly assessments End-user analysis within each report Key Features

3. © Copyright 2002 Frost & Sullivan. All Rights Reserved. Coverage: The United States Proven methodology encompassing extensive primary and secondary data and research Focused information and strategies that cover business and technology issues Credible data and analysis highlighting industry dynamics Winning strategies to help you create precise business plans What We Offer

4. © Copyright 2002 Frost & Sullivan. All Rights Reserved. Current Market Participants Find out how you compare to the competition Assess current and future drivers and restraints Determine and exploit new market share opportunities New Entrants Analyze challenges associated with the industry Calculate time scales for strategy implementation Position yourself to capitalize on the market’s unmet needs Investment Community Analyze long-term strategies of companies Determine which participants will outperform the competition Assess attractiveness of investing in the market Who Will Benefit?

5. © Copyright 2002 Frost & Sullivan. All Rights Reserved. Advanced Tissue Sciences Akorn, Inc. Alcon Laboratories, Inc. Allergan American Home Products Anika Therapeutics, Inc. Artes Medical, Inc. Bausch & Lomb Surgical Biomatrix Biomet Orthopedics, Inc. Bio-Technology General Corp. Collagenesis, Inc. Cytosol Ophthalmics, Inc. DePuy Orthopaedics, Inc. Fidia S.p.A. Key Market Participants Genzyme Biosurgery INAMED Corp. Johnson & Johnson Novartis Obagi Medical Products, Inc. OrthoLogic Corp. Pharmacia & Upjohn Priority Healthcare Corp. Q-Med Scandinavia, Inc. Q-Med, Inc. Sanofi-Synthelabo Inc. Smith & Nephew Inc./Orthopaedic Division Staar Surgical Co. Wyeth Zimmer

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