1. ENDOMETRIOSIS
DEPT OF OBS & GYNAEC
AMC

2. ENDOMETRIOSIS
DEFINITION: presence of endometrial tissue (glands & stroma) outside the uterine cavity.
Incidence is about 10%.
Most common in women of reproductive age group.
It is an oestrogen dependent disease.

3. ETIOLOGY
Various theories proposed to explain the histogenesis of endometriosis:
1)IMPLANTATION THEORY
2)COELOMIC METAPLASIA THEORY
3)INDUCTION THEORY
4)METASTATIC THEORY
5)HORMONAL INFLUENCE THEORY
6)IMMUNOLOGICAL THEORY

4. ETIOLOGY contd.,
Implantation theory: this theory explains that endometriosis is caused by implantation of endometrial cells by trans tubal retrograde menstruation.
eg.1) Endometriosis in dependent portions of pelvis – ovaries, uterosacral lig., cul-de-sac etc.,
2) Scar endometriosis following classical caesarian section, hysterotomy & episiotomy.

5. ETIOLOGY contd.,
Coelomic Metaplasia theory: endometriosis arises as a result of metaplastic changes in embryonic cell rests of embryonic mesothelium which respond to hormonal stimulation.
Induction theory: it proposes that an endogenous biochemical factor can induce undifferentiated peritoneal cells to develop into endometrial tissue.

6. ETIOLOGY contd.,
Metastatic theory: this thoery explains extra pelvic endometriosis which result from vascular or lymphatic dissemination of endometrial cells to gynaecological ( vulva, vagina, cervix) and non gynaecological sites like bowel, pelvic lymph nodes, ureter, lung, pleura etc.
Hormonal Influence theory: after implantation development of endometriotic implants depend on presence of hormones mainly oestrogen.

7. ETIOLOGY contd.,
Immunological theory: endometriosis can be caused by decreased clearance of peritoneal fluid endometrial cells resulting from reduced Natural Killer cell activity or decreased macrophage activity.

8. SITES OF ENDOMETRIOSIS
Most common site is ovary.
Other sites – cul-de-sac including uterosacral lig., back of uterus, posterior broad lig, peritoneum overlying bladder, intestinal coils etc.,
Scar endometriosis occur in umbilicus following laparotomy, tubal stumps following tubectomy, amputated stumps of cervix, episiotomy scars etc,

9. SITES OF ENDOMETRIOSIS

10. PATHOLOGY
An endometriotic lesion appears as dark red, bluish or black cystic area adherent to site where it is lodged.
Scarring around the lesion gives puckered appearance.
Powder burnt areas represent inactive lesions.

11. PERITONEAL ENDOMETRIOSIS

12. BLUE –BLACK APPEARANCE OF LESIONS

13. HISTOLOGY
Histological confirmation is essential in the diagnosis of endometriosis.
Microscopically, endometrial implants consist of endometrial glands & stroma with or without hemosiderin laden macrophages.
Endometriod stroma is more characteristic of endometriosis than endometrial glands.

14. HISTOLOGY OF ENDOMETRIOTIC LESION

15. CHOCOLATE CYST OF OVARY
Also called as endomeriotic cyst of ovary.
Exclusive ovarian disease found in only 1% of patients.
Ovarian endometriosis appears to be a marker of more extensive pelvic & intestinal disease.
FORMATION OF CHOCOLATE CYST:
Islets of endometriosis show cyclical changes during menstruation menstrual blood & debris collect collection with each episode absorption of fluid causes blood to become dark coloured to produce chocolate cyst.

16. CHOCOLATE CYST cont, Features of choclate cyst:
1.cyst diameter <12 cm
2.adhesion to pelvic side wall or broad
lig
3.endometriosis on surface of ovary
4.contains tarry,thick,chocolate
coloured fluid
It consists of thick tunica albuginea & vascular red adhesions on undersurface of ovary.

17. CHOCOLATE CYST

18. CHOCOLATE CYST OF OVARY

19. CLASSIFICATION Revised American Fertility Society Classification
Classification based on size & location of the endometriotic lesion.
Classified as minimal, mild, moderate & severe.
Classification correlated with fertility outcome rather than symptoms.

20. CLASSIFICATION

22. CLINICAL FEATURES
SYMPTOMS: classical symptoms include dysmenorrhoea, dyspareunia & infertility.
Dysmenorrhoea: usually congestive type.
pain related to location not extent of lesion.
Dyspareunia: involvement of cul-de-sac & uterosacral lig., produce adhesions & fixation of uterus. Movements of cervix elicit tenderness.

23. CLINICAL FEATURES
Infertility: involvement of ovaries produce adhesions blocking tubo-ovarian motility & ovum pick up leading to infertility.
Chronic pelvic pain: brownish yellow peritoneal fluid containing PGE2 is responsible for pain.
Endocrinological abnormalities: anovulation, luteal insufficiency, lutenisation of unruptured follicle, hyperprolactinemia etc,
Others: adhesions around ureter produce hydronephrosis, painful defaecation & melaena due to invol., of sigmoid colon.

24. ENDOMETRIOSIS LESIONS & ADHESIONS

25. CLINICAL FEATURES SIGNS:
abdominal examination: may reveal tender & fixed cystic mass in case of chocolate cyst.
Speculum examination: may reveal bluish or blackish puckered spots in posterior fornix.
P/V: may reveal fixed tender retroverted uterus, cobble stone feel of uterosacral lig, thickened nodules in pouch of douglas etc,

26. DIFFERENTIAL DIAGNOSIS
Pelvic inflammatory diseaes
Uterine myomas
Malignant ovarian disease with metastasis in pouch of douglas
D.D of acute abdomen in case of ruptured chocolate cyst
Chronic pelvic congestion syndrome
Rectal carcinoma when involves rectovaginal septum

27. INVESTIGATIONS
Ultrasound: TVS may reveal an echo free cyst whose wall is thick & irregular.
Laparoscopy: laparoscopy is gold standard in the diagnosis of endometriosis.
Histological confirmation
CA125:it is a glycoprotein & cell surface antigen. Raised >35U/ml proportional to extent of disease. Raised level indicate recurrence or persistence of disease.

28. TREATMENT If asymptomatic observe for 6-8 months. Medical treatment :
Indications: a) mild pelvic endometriosis
b)to treat residual& recurrent
disease following surgery
OC PILLS: the objective of treatment is induction of amenorrhoea pseudo pregnancy & decidualisation of endometrial tissue which relieves pain & dysmenorrhoea.
Dose :low dose OCP containing 30-35mcg of oestrogen for 6-12 months.
PROGESTINS: considered as first choice for treatment of endometriosis with lower incidence of side effects.

29. TREATMENT
DANAZOL: inhibits pituitary gonadotropins. It has anti-oestrogenic ,anti progestational & androgenic.
Dose: mg for 3-6 months.
GnRH ANALOGUES: cause atrophy of endometrial tissue
AROMATASE INHIBITORS- letrozole
MINIMALLY INVASIVE SURGERY:
Goal of surgery is to excise all visible endometriotic lesion & associated adhesions & restore normal anatomy.

30. MINIMALLY INVASIVE SURGERY
Ovarian endometrioma < 3cm in diameter removed by vapourisation by CO2 OR Nd:YAG laser.
Ovarian cystectomy done for ovarian endometriotic cyst > 3 cm in diameter.
Laparoscopic adhesiolysis: restore patency of tubes.
LUNA(laparoscopic uterosacral nerve ablation): relieves pain.

31. LAPAROSCOPIC ADHESIOLYSIS

32. LAPAROSCOPIC EXCISION OF ENDOMETRIOTIC CYST

33. TREATMENT LAPAROTOMY: presevered for advanced stage disease.
Salpingo-oophorectomy
Abd hysterectomy & bil salpingo-oophorectomy.
COMBINED TREATMENT: pre operative medical treatment reduce vascularisation & size of nodules.
post operative treatment decerase the incidence of recurrence.

34. PROPHYLAXIS
Low dose OCP reduce endometrial growth & protect against endometriosis.
Tubal patency tests should be avoided in immediate pre menstrual phase.
Operations on the genital tract should be done in post menstrual phase.
Classical c/s & hysterotomy may cause scar endometriosis & hence should be avoided.

35. thank you