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'Neuroinflammation, excitotoxic and neurodevelopmental disease induce specific forms of Neuronal plasticity: Towards novel platforms for pharmacological.

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Presentation on theme: "'Neuroinflammation, excitotoxic and neurodevelopmental disease induce specific forms of Neuronal plasticity: Towards novel platforms for pharmacological."— Presentation transcript:

1 'Neuroinflammation, excitotoxic and neurodevelopmental disease induce specific forms of Neuronal plasticity: Towards novel platforms for pharmacological screening and biomarker discovery?’ 3U-COEN Centre of Excellence in the Neurosciences Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland Dr Hans-Georg Koenig Lecturer in Physiology hgkoenig@rcsi.ie We do: Disease programmes ALS Alzheimer’s disease Neuroinflammation Stroke Thematic areas: Excitotoxicity Axon-initial segment & axonal plasticity Neural Stem cells & Neurospheres NF-  B and Growth-factor signaling We have : Live cell imaging LSM and High-content imaging facilities and broad Neuro culture know how!

2 We seek: Natural compounds/libraries towards: –AIS / Axon-protective strategies –Neuroprotective strategies –Affect axon-specification –Anti-inflammatory –Preservation of Mitochondrial respiration –‘Neuroenhancer’ potential Peptide biomarker screening Nanoparticles transduction of neurons / stem cells Blood-brain barrier model iNeurons & iPSCs

3 hgkoenig@rcsi.ie +353-1-402-2122 Please join us this Thursday, 26/02, 14:30 PM, Royal College of Surgeons, RBI-3U - Neuroscience Day Topics: Excitotoxic & metabolic nervous system disorders Alzheimer Schizophrenia Psychosis Bipolar disease Epilepsy Neural Stem Cells http://www.rcsi.ie/csnd http://www.neuro-centre.ie/research/ Prof. Jochen Prehn prehn@rcsi.ie Dr Hans-Georg Koenig

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