1. Mentor’s advice Peer advice Why a fellowship Write a Compelling story Pilot data Letters of recommendation What budget can be used for Goal setting MSTP Fellowship and Career Development Support Alison Hall, Ph.D. Office of Graduate Education Career Development

2. De-Mystifying the Process 1.Support as an MSTP student 1.Fellowship—NIH F30/31 2.Non-federal funding 2. Next funding steps after graduation 1. Career Development—NIH K08 2. Independence—NIH K02/R01 3. Components of an effective proposal

3. National Research Service Awards (NRSA) –F30, 31 Predoctoral Fellowships –F32Postdoctoral Fellowships Career Development Awards –K01Mentored Research Scientist Development Awd –K08 Mentored Clinical Scientist Development Awd –K23Mentored Patient-Oriented Research –K99/00Pathway to Independence Award

4. Who has NIH support? NIH Reporter http://projectreporter.nih.gov/reporter.cfm Examples… Graduate Education Office..

5. The NIH NRSA Ruth L Kirschstein Stipend FY 2011 Predoctoral$21,600 Postdoctoral Years of Experience: 0$38,496 1$40,548 Tuition Training Related Expenses Predoctoral Trainees: $4,200 Postdoctoral Trainees: $7,850

6. F award http://grants.nih.gov/training/f_files_nrsa.htm F KIOSK Up to 3 years funding Tips and samples http://grants.nih.gov/grants/grant_tips.htm_process.htm http://grants.nih.gov/grants/grant_tips.htm Deadlines 3 times per year usu Apr 8, Aug 8, Dec 8 electronic submissions!

7. F30 / 31 funding for MSTP students F31 Diversity PA-11-112 for URM students supports PhD phase, includes most institutes F31 NIH PA-11-111* supports PhD phase F30 Parent MD-PhD NIH PA-11-110* supports MD and PhD phases *NCI, NIA, NIAAA, NIDCD, NIDCR, NIDA, NIMH, NINDS, NCCAM

8. NRSA predoctoral proposal components: Specific Aims (1 page) 3 aims Research Strategy (6 pages) Sponsor/co-sponsor info Respective Contribution (1 page) Responsible Conduct of Research (1 page) Goals for fellowship training and career (1 page) Activities planned under this award (1 page) Dissertation and other research experience (2 pages) Three letters of reference Biosketch including courses and grades More than research--incorporate training goals

9. Reviewer Criterion Scores Applicant Sponsors, collaborators Research Training Plan Training Potential Institutional environment, commitment to training new techniques new collaborators present at meetings, go to courses timeline including publication plan advisory committee meet six mos for feedback

10. Non-Federal (Foundations, Corporations, etc) Grantsnet Advanced search “Research Funding”, Individual “early doctoral student” “PhD dissertation student” Research area (optional, choose many) Often single deadline per year …Plan to apply to Feds and Foundations

11. Example American Society Of Microbiology Robert D. Watkins Minority Graduate Fellowshiphttp://www.asm.org/Education/index.asp? bid=6278http://www.asm.org/Education/index.asp? bid=6278 3 years graduate coursework completed by activation date mentored by an ASM member May 1 deadline annually

12. Example American Heart Association (Great Rivers affiliate) Cardiovascular and stroke research $22,000 plus $1K fringe 1-2 years, option 3 Jan deadline, starts July

13. Inform Cliff before preparing the application MSTP specific instructions maximum allowable period, 6 yr max on an NIH training mechanism Choose best funding for MD-PhD training incl covering the MD phase if possible Project max. training period, max. tuition— anything left over will revert back to the NIH

14. Career Development Awards K01Mentored Research Scientist Development Awd K08 Mentored Clinical Scientist Development Awd K23Mentored Patient-Oriented Research K99/00Pathway to Independence Award Provides protected time for mentored research Get pilot data during residency/fellowship 2. Next funding steps after graduation

15. K08 Mentored Clinical Scientist Development Award K Kiosk http://grants.nih.gov/training/careerdevelopmentawards.htm For clinically trained persons to pursue research careers in basic or clinical sciences Must apply within 3 years of clinical training partial salary (up to $100K) some research costs (30-50K) up to five years Not uniform salary—see Institute!! (this is NCI) 75% effort (50% surgery)

16. The K08 Three letters of reference Specific aims 1 page All in 12 pages: Candidates background Career goals and objectives Career development plan/ training activities Training in RCR Research Strategy

17. The K08 AGAIN Career Development Plan (very important) learn new techniques, new area, fundable present at meetings, review grants, courses Update didactics Timeline including publication plan advisory committee familiar with research, career goals, meet six mos for feedback

18. Copyright restrictions may apply. Dickler, H. B. et al. JAMA 2007;297:2496-2501. First-Time Applicants for R01 Grants by Degree (1964-2004) and Percentage Awarded (1964-2003) # physician investigators applying for first R01s little change for 3 decades Those proposing clinical work less successful MD-PhDs are few, but successful!

19. 3. Components of an effective proposal Most applications electronic Assigned to Scientific Review Group Study section review NIH Scores 1 (great)- 9 (poor) Summary sheet http://grants.nih.gov/grants/partners/NexusImages/September06/submit.jpg

20. Write for the Reviewers Reviewers are: –Smart –Accomplished –Dedicated –Fair Phyllis McBride, Ph.D. p-mcbride@tamu.edu

21. Write for the Reviewers Reviewers are also: –Busy –Overworked –Skeptical –May not be as knowledgeable about the details Phyllis McBride, Ph.D. p-mcbride@tamu.edu

22. What is the benefit of answering your question? Who will it help and how? Make a definitive statement on purpose of your research why it should be funded A strong research idea passes the “so what” test

23. Specific Aims (1 p max) Propose 2 or 3 aims Provide a rationale—where did hypothesis come from? why is this a strong idea? Provide a hypothesis to be tested with a specific aim Have objectives that are measurable and focused

24. Research Strategy (6 p max) background and significance no more than a page not a wikipedia on the subject!! lead to remaining question each paragraph Pilot data--perhaps a year of work? Plan to submit right after qualifier

25. Research Strategy, continued How test hypothesis, what approach? Propose to learn two techniques within plan Describe who will teach you and how Include collaborators, letters as needed Cite, but do not expect reviewer to read papers Provide general scope of experiment Include “Anticipated outcome and Alternative interpretations” for each aim

26. Sponsor/co-sponsor info research expertise training experience and success may need to choose add’l senior person describe when meet Responsible Conduct of Research IBMS 500 + advanced ethics Goals for fellowship training and career thesis committee composition, mtgs coursework CSH, other instns publications, national meetings Professional skills

27. Plan to submit the research training proposal to several agencies; you can submit to many, but accept only one You will get a summary statement, and may have to resubmit—address questions in Introduction Every MSTP student is fundable—