1. Future Research Directions Improving the Chain of Recovery for Acute Stroke in Your Community

2. Overview Disease understanding Genetics/Genomics/Proteomics Primary Prevention Cerebrovascular disease Stroke Secondary Prevention Acute Stroke Treatment Recovery and Rehabilitation

3. Overview Disease understanding Genetics/Genomics/Proteomics Primary Prevention Cerebrovascular disease Stroke Secondary Prevention Acute Stroke Treatment Recovery and Rehabilitation

4. Trial Preparation Now More Creative Methodology More Thorough Phase I and Phase II Studies

5. Trial Design Now Simpler Larger

6. Trial Design Now Simpler Larger $$$$$$

7. Disease Target Stroke SAH Stroke SAH +ICH

8. Trial Organization Academic Consortium Networks of Practicing Physicians

9. Ischemic Stroke Refining Thrombolysis Drug Dose Route Clot removal Neuroprotection Combination Early treatment Hypothermia

10. Research Community Increasingly, clinical trials will become a part of clinical practice.

11. Conclusions The distinction between research and practice will diminish

12. Conclusions The distinction between research and practice will diminish. The importance of rapid response and early intervention will NOT change.

13. Conclusions The distinction between research and practice will diminish. The importance of rapid response and early intervention will NOT change. Disability and death from stroke will be reduced in gradual decrements in an ongoing process.

14. Conclusions The distinction between research and practice will diminish. The importance of rapid response and early intervention will NOT change. Disability and death from stroke will be reduced in gradual decrements in an ongoing process. There will be a trial testing an intervention for every stroke patient.