1. Arsenic Contamination of GroundWater.By
Sadman Bin Sazzad

2. Epidemiology
A 2007 study found that over 137 million people in more than 70 countries are probably affected by arsenic poisoning of drinking water. Arsenic contamination of ground water is found in many countries throughout the world, including the US.
It is a serious problem in Bangladesh.  Prior to the 1970s, Bangladesh had one of the highest infant mortality rates in the world. Ineffective water purification and sewage systems as well as periodic monsoons and flooding exacerbated these problems
As recent as 2010, more 20% death in Bangladesh was caused by Arsenic Poinsoning.

3. The Tubewell

5. Causes Drinking Water (like duh!)………main cause in Bangladesh
Occupational Exposure. Due to its high toxicity, it is not used much in US. Arsenic is mainly encountered occupationally in the smelting of zinc and copper ores.
Food. Example is Rice. Accumulation of Arsenic in crops form soil.

6. What is Arsenic?
"1. A metallic element, atomic no. 33, atomic wt ; forms a number of poisonous compounds, some of which are used in medicine Denoting the element arsenic or one of its compounds, especially arsenic acid."

7. Arsenic poisoning.
Arsenic poisoning or arsenicosis is a condition caused by the ingestion, absorption or inhalation of dangerous levels of arsenic. Arsenic is a natural semi-metallic chemical that is found all over the world in groundwater. 

8. How does it affect our body?
Pyruvate (3C)
Arsenic compounds disrupt ATP production through several mechanisms.
At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis.
Hydrogen peroxide production is also increased, which might form reactive oxygen species causing oxidative stress.
These metabolic interferences lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. A post mortem reveals brick red colored mucosa, due to severe hemorrhage.
Glucose (6c)
Pyruvate (3C)
CoA and NAD+
Pyruvate Decarboxylase Complex
(enzyme)
NADH2

9. Symptoms drowsiness headaches confusion terrible diarrhea
metallic taste in the mouth
mouth produces excess saliva
problems swallowing
blood in the urine
cramping muscles
loss of hair
stomach cramps
convulsions
excessive sweating
breath smells like garlic
vomiting
diarrhea
(More Severe)
drowsiness
headaches
confusion
terrible diarrhea
(less severe)

10. Treatments Combination drug therapy
Anti-oxidants in aloe vera can combat the oxidative stress
Removing contaminated clothes and thoroughly rinsing skin
Bowel irrigation-passing large amount of polyethylene solution to flush out arsenic
Supportive treatment for complication like heart failure.

11. In countries like Bangladesh emphasis is to put on to prevent Arsenic poisoning!
Treatments can be too expensive
METHODS TO PREVENT:
Fixing arsenic removal systems in homes
Periodically testing drinking water for Arsenic
Rainwater harvesting
Digging adequately deeps wells