1. DynaPulse Non-invasive Blood pressure and Hemodynamic Monitoring Example Applications: Cardiac Rhythm & Hypertension Managements www.dynapulse.com Pulse Metric USA

2. Cardiac Rhythm Management: Pulse waveform of each measurement identifies cardiac rhythm…… Normal Every Time A Blood Pressure Measurement is Taken… Arrhythmia

3. Pulse Waveform is Displayed for Each Measurement …… The adoption of DynaPulse technology by physicians will result in more patients with arrhythmias being identified and referred to the electro-physiologist and significantly improve the Cardiac Rhythm Management.

4. Managing 140/90 Borderline Hypertension with DynaPulse Case-1 had blood pressure of 140/91 with higher cardiac output (CO=8.42 vs. 4.25) and lower systemic vascular resistance (SVR=1016 vs. 2053), suggested case-1 use beta-blocker for treatment. Case-2: Had blood pressure of 142/91, but with lower brachial artery distensibility (BAD=4.49 vs. 6.46) and compliance (BAC=0.047 vs. 0.123), which indicated Case-2 had stiffer peripheral arterials and vessel-dilating drug ACEI was suggested.

5. Hypertension Management: Hemodynamic values provide beyond Systolic/Diastolic for managing hypertension…… Case 1 (140/91)Case 2 (142/91)

6. Hemodynamics in Hypertension Hemodynamic values provide beyond Systolic/Diastolic for managing hypertension……

7. Hypertension Management: Hemodynamic values provide beyond Systolic/Diastolic for managing hypertension…… Case 1 (140/91) ”Beta-Blocker…for high CO…” Case 2 (142/91) ”ACEI…for high SVR and low SVC, BAC & BAD…”

8. Advanced Clinical Applications: 24 Hour Ambulatory Blood Pressure & Hemodynamic Monitoring… 24-hr ABP monitoring (ABPM) can Identify Dipper, non-Dipper & over-Dipper… It’s more predictive than office BP measurements. 24-hr Hemodynamic profiling provides unique and advanced clinical applications…

9. 24 Hour Ambulatory Blood Pressure Monitoring (ABPM) ABPM is ideal for I. Clinical evaluations of: White Coat HPTN Essential HPTN Heart disease/HPTN Renal disease/HPTN II. Clinical studies on: HPTN drugs & effectiveness Stroke/CAD/CHF & HPTN Diabetes & HPTN Obesity & HPTN Genetics & HPTN Pregnancy & HPTN Occupation/Stress & HPTN ABPM is reimbursable nationwide for Hypertension (HPTN) evaluations since 2003 via ICD-9 codes and CPT codes.

10. The Advantage Brachial Artery Compliance Cardiac Output Systemic Vascular Resistance LV dP/dt DynaPulse  is the only technology that acquires blood pressures, central and peripheral hemodynamic values Simultaneously. 24-Hour ABPM

11. The Easy-To-Use Hemodynamic Profile DynaPulse  is the only technology that acquires blood pressures, central and peripheral hemodynamic values Simultaneously.

12. The Clinically Proven Technology DynaPulse  is the only technology that acquires blood pressures, central and peripheral hemodynamic values Simultaneously. Pulse Dynamics e-book describes the physics of DynaPulse technology, and summarizes its clinical validation & application studies since 1995.

13. Whose Using It: Parke Davis

14. Whose Using It:

15. Thank you www. dynapulse.com