1. When you are done with your quiz… 1.Turn it in to Mrs Akl. 2.Pick up a “Pedigree Analysis” Worksheet 3.Cut and paste it onto the next left side of your IntNB. 4.Draw your immediate family’s pedigree based upon the rules on the worksheet.

2. Overview I.What is a pedigree? A. DefinitionDefinition B. UsesUses II. Constructing a pedigree A. SymbolsSymbols B. Connecting the symbolsConnecting the symbols C. ExampleExample III. Interpreting a pedigreeInterpreting a pedigree

3. A Pedigree is… Generally: A genetic family tree Specifically: It is a chart of the genetic history of family over several generations. Back to Overview

4. A Pedigree is used to… Diagnose the likelihood of a disease or trait.Diagnose the likelihood of a disease or trait. Scientists or a genetic counselor would find out about your family history and make this chart to analyze.Scientists or a genetic counselor would find out about your family history and make this chart to analyze. Back to Overview

5. Constructing a Pedigree Female Male

6. Affected X-linked Autosomal carrier Deceased Constructing a Pedigree Back to Overview

7. Connecting Pedigree Symbols Married couples Siblings Examples of connected symbols:

8. Connecting Pedigree Symbols Fraternal twins Identical twins Examples of connected symbols: Back to Overview

9. What does a pedigree chart look like? I. II. III.

10. Interpreting a Pedigree Chart 1.Determine if the pedigree chart shows an autosomal or X-linked disease. a.If most of the males in the pedigree are affected the disorder is. b.If it is a 50/50 ratio between men and women the disorder is. X-linked autosomal

11. Example of Pedigree Charts Is it Autosomal or X-linked?

12. Answer Autosomal: Males and Females are equally affected.

13. Interpreting a Pedigree Chart 2.Determine whether the disorder is dominant or recessive. a.If the disorder is dominant, one of the parents must have the disorder. b.If the disorder is recessive, neither parent has to have the disorder because they can be heterozygous.

14. Example of Pedigree Charts Dominant or Recessive?

15. Answer Dominant: It is found in every generation

16. Example of Pedigree Charts Dominant or Recessive?

17. Answer Recessive: It does not appear in every generation

18. Summary Pedigrees are family trees that explain your genetic history. Pedigrees are used to find out the probability of a child having a disorder in a particular family. To begin to interpret a pedigree, determine if the disease or condition is autosomal or X-linked and dominant or recessive.