1. 1 Longevity and Tea

2. 2 Tegreen 97 n Second most popular beverage n Tremendous positive press n Top 20 in health food sales n Thousands of studies worldwide u Including National Cancer Institute n Dose: 250 mg capsule; 1 capsule/day with food Tea is HOT!

3. 3 Proprietary processing n Only finest leaf buds and young leaves used n Cultivated in Zhejiang province (number one tea-producing region in China) n Proprietary extraction process u Achieves 97% polyphenols F 65% Catechins 38% EGCg

4. 4 Green tea vs. Black tea n Green tea n Camellia sinensis n Non-fermented u Lightly steamed and dried n Benefit of process u Preservation polyphenols (similar to fresh leaves) n Black tea n Camellia sinensis n Fermented and dried. n Benefit of process u Flavor enhancing n Disadvantage u Destroys polyphenols

5. 5 Green tea research n Epidemiological studies on green tea drinkers n Polyphenol Research u Proven antioxidants u Cell protection u Inhibition of abnormal cell proliferation

6. 6 What are Polyphenols? n Powerful antioxidants n High concentrations in green tea n Tegreen enriched for polyphenol anti- oxidants, particularly Epigallocatechin gallate (EGCg)

7. 7 TeGreen 0 20 40 60 80 10 20 30 40 0 Dose (µM) Vitamin C Vitamin E Antioxidant potency Example of Pharmanex research on Tegreen EGCG

8. 8 3 glasses of red wine 4 cups of green tea 4 glasses of iced tea Based on EGCg levels Anti-oxidant equivalency to other beverages without caffeine or alcohol

9. 9 New Research by Pharmanex collaborators n Abnormal cells proliferate and live longer than normal cells n The life of a normal cell is regulated by a natural regulatory mechanism called programmed cell death (apoptosis) n Apoptosis is severely limited in abnormal cells n Pharmanex collaborators discovered unique enzyme (tNOX) in abnormal cells associated with this defect

10. 10 Inhibition of enzyme (tNOX) activity in cancer cells 0 0.5 1 1.5 2 2.5 3 3.5 4 Control10 nM1000 nM 100000 nM EGCg Tegreen Cancer cell enzyme activity Source: Morre et al.

11. 11 Tegreen Vs EGCg in promoting cancer drug activity 0 1 2 3 4 5 0110100100010000 Anti-cancer drug alone Tegreen + Anti-cancer drug Anti-cancer drug, glaucarubolone, nM Cancer cell killing

12. 12 Tegreen 97 Attributes n Highest levels of polyphenols in industry u 97% polyphenols u Most competitors: 50-65% polyphenols n Once per day dose u Equivalent to 4 cups of green tea beverage n Caffeine free