1. Do Now: Mrs Frankenstein’s Spider Goats! Mane, 24 Here-turi-kōkā 2015

2. Reminders: Test on Friday: - covers heart, lungs, genetics & diseases

3. Today’s kaupapa: What is the difference between an inherited genetic disease and a disease that you catch like the flu? Mane, 24 Here-turi-kōkā 2015

4. Watch: Oli and Nush – complete worksheet (active listening!) Mane, 24 Here-turi-kōkā 2015

5. Cystic Fibrosis less gas exchange repeated chest infections – bacteria are trapped and thrive in the thick mucus. Thick mucus blocks the alveoli – why is this a problem? lung alveoli mucus Less oxygen delivered to cells for respiration Click for a clue:

6. Cystic Fibrosis (CF) cannot be “caught” like the flu – so how is it passed on? It is passed on to you from your parents genes, not other people Colds and flu are caused by microbes (bacteria and viruses) which can be caught from other people You will have a genetic disease for life, but your body will fight diseases caused by microbes and you will get better It is a genetic disease which is inherited Click for a clue:

7. CF is caused by a recessive allele (f) The normal allele (F) is dominant Someone who has the f allele is a carrier They don’t have the disease, but can pass it on to their children

8. 1) Which people have cystic fibrosis? 2) Name someone who is a carrier 3) Predict what alleles Bob could have 4) Name someone who is homozygous dominant 5) What is Sarah’s phenotype? f: has cystic fibrosis (recessive) F: does not have cystic fibrosis (dominant)

9. CF is caused by a recessive allele (f) The normal allele (F) is dominant Someone who has the f allele is a carrier They don’t have the disease, but can pass it on to their children 1) Draw a Punnet square for Julie (Ff) and John’s (Ff) children - what is the probability they have a child with CF? 2) Draw a Punnet square for David (FF) and Sarah’s (Ff) children - what is the probability they have a child with CF?

10. Clips: The Terrifying Truth About Bananas (4 min) Symphony of Science – Evolution (4 min) What is Evolution? (9 min)