1. William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 22 Applications and Ethics of Biotechnology Copyright © 2006 Pearson Prentice Hall, Inc.

2. Biotechnology Has Revolutionized Agriculture Transgenic Crops and Herbicide Resistance

3. Figure 22-1 Copyright © 2006 Pearson Prentice Hall, Inc.

4. Figure 22-2 Copyright © 2006 Pearson Prentice Hall, Inc.

5. Nutritional Enhancement of Crop Plants

6. Figure 22-3 Copyright © 2006 Pearson Prentice Hall, Inc. “Golden Rice” High levels of β-carotene

7. Concerns about Genetically Modified Organisms

8. Pharmaceutical Products Are Synthesized in Genetically Altered Organisms Insulin Production in Bacteria

9. Figure 22-4 Copyright © 2006 Pearson Prentice Hall, Inc.

10. Table 22-1 Copyright © 2006 Pearson Prentice Hall, Inc.

11. Pharmaceutical Products Are Synthesized in Genetically Altered Organisms Transgenic Animal Hosts and Pharmaceutical Products

12. Figure 22-5 Copyright © 2006 Pearson Prentice Hall, Inc.

13. Transgenic Plants and Edible Vaccines (“subunit vaccines”)

14. Figure 22-6 Copyright © 2006 Pearson Prentice Hall, Inc.

15. Figure 22-7 Copyright © 2006 Pearson Prentice Hall, Inc.

16. Biotechnology Is Used to Diagnose and Screen Genetic Disorders

17. Figure 22-8 Copyright © 2006 Pearson Prentice Hall, Inc. 15 -20 weeks

18. 10 -12 weeks

19. Prenatal Diagnosis of Sickle-Cell Anemia

20. Figure 22-9 Copyright © 2006 Pearson Prentice Hall, Inc.

21. Nucleotide Polymorphisms and Genetic Screening Allele-specific oligonucleotides

22. Figure 22-10 Copyright © 2006 Pearson Prentice Hall, Inc.

23. Figure 22-11 Copyright © 2006 Pearson Prentice Hall, Inc.

24. DNA Microarrays

25. Figure 22-12 Copyright © 2006 Pearson Prentice Hall, Inc.

26. Figure 22-13 Copyright © 2006 Pearson Prentice Hall, Inc.

27. Gene expression profiling

28. Figure 22-14 Copyright © 2006 Pearson Prentice Hall, Inc.

29. Disease Diagnosis

30. Figure 22-15 Copyright © 2006 Pearson Prentice Hall, Inc.

31. Figure 22-16 Copyright © 2006 Pearson Prentice Hall, Inc.

32. Genome Scanning

33. Figure 22-17 Copyright © 2006 Pearson Prentice Hall, Inc.

34. DNAPrint · 900 Cocoanut Ave. · Sarasota, FL 34236 This e-mail message is an advertisement and/or solicitation.

35. Genetic Testing and Ethical Dilemmas

36. Genetic Disorders Can Be Treated by Gene Therapy

37. Figure 22-18 Copyright © 2006 Pearson Prentice Hall, Inc.

38. Gene Therapy for Severe Combined Immunodeficiency (SCID)

39. Figure 22-19 Copyright © 2006 Pearson Prentice Hall, Inc. Ashanti De Silva

40. Figure 22-20 Copyright © 2006 Pearson Prentice Hall, Inc.

41. Figure 22-21 Copyright © 2006 Pearson Prentice Hall, Inc.

42. Problems and Failures in Gene Therapy

44. Science 2003 302: 415-419

45. Future of gene therapy? Table 22-2 Copyright © 2006 Pearson Prentice Hall, Inc.

46. Gene Therapy Raises Many Ethical Concerns Somatic versus germ-line “Common good” versus individual benefit Enhancement gene therapy

47. Ethical Issues Are an Outgrowth of the Human Genome Project The Ethical, Legal, and Social Implications (ELSI) Program http://www.ornl.gov/sci/techresources/Human_Genome/elsi/elsi.shtml

48. Finding and Mapping Genes in the Human Genome with Recombinant DNA Technology RFLPs as Genetic Markers

49. Figure 22-22 Copyright © 2006 Pearson Prentice Hall, Inc.

50. Linkage Analysis Using RFLPs

51. Figure 22-23 Copyright © 2006 Pearson Prentice Hall, Inc.

52. Finding and Mapping Genes in the Human Genome with Recombinant DNA Technology Positional Cloning: The Gene for Neurofibromatosis

53. Figure 22-25 Copyright © 2006 Pearson Prentice Hall, Inc. Neurofibromatosis

54. DNA Fingerprints Can Identify Individuals Minisatellites (VNTRs) and Microsatellites (STRs)

55. Figure 22-27 Copyright © 2006 Pearson Prentice Hall, Inc.

56. Figure 22-28 Copyright © 2006 Pearson Prentice Hall, Inc.

57. Forensic Applications Paternity testing

59. November 21, 2005 Article 1 Preimplantation Genetic Diagnosis (PGD) Article 2

60. That’s All!