1. Dermatology 2006 SNU Dermatolory Lab Bioinformatics for Genomic Medicine 2006 Dermatology Lab Yoonkyung Kim 0 Term Project Proposal Presentation 2006. 06. 12

2. Term Project Proposal Presentation 1 Dermatology 2006 SNU Dermatolory Lab 1 Database : Online Mendelian Inheritance in skin with OMIM DB

3. Term Project Proposal Presentation 2 Dermatology 2006 SNU Dermatolory Lab 2 Introduction Online Mendelian Inheritance in Man (OMIM) OMIM is a continuously updated catalogue of human genes and genetic disorders. OMIM focuses primarily on inherited, or heritable, genetic diseases. It is considered to be a phenotypic companion to the human genome project. OMIM is based upon the text Mendelian Inheritance in Man, authored and edited by Dr. Victor A. McKusick and a team of science writers and editors at Johns Hopkins University and elsewhere. Mendelian Inheritance in Man(MIM) is now in its 12 th edition. See McKusick, V.A.: Mendelian Inheritance in Man. 12th ed., Baltimore: Johns Hopkins University Press, 1998.

4. Term Project Proposal Presentation 3 Dermatology 2006 SNU Dermatolory Lab 3 Purpose - Limitation of datas about skin genetic disorders in OMIM - the updated data in other databases is considerably insufficient. OMIK(Online Mendlian Inheritance in Korea) : information is simple and Page error 국립보건원 : late update Korea Cytogenetic DB : page error - All of the database is not up to date ( old ) - Databases include overlapped cytogenetic DB - contents of the databases are insufficient for professional and accuracy

5. Term Project Proposal Presentation 4 Dermatology 2006 SNU Dermatolory Lab 4 Method OMIM Get id from html pages(/omimhtml) ( skin search ) Method : python 2.4 Searched results with skin : 2189 Raw data Download the pages(/omimsubhtml) with id Method : python 2.4 html data Extract the datas from downloaded pages Method : python 2.4

6. Term Project Proposal Presentation 5 Dermatology 2006 SNU Dermatolory Lab 5 extracted data Method insert datas (text file) to the data table Method : MS Access !! but except data if data is too large to insert to the table Data table Make form for the table form Coding to add search function with visual basic Method : MS Access (visual basic) Skin DB Method : MS Access

7. Term Project Proposal Presentation 6 Dermatology 2006 SNU Dermatolory Lab 6 Result search Title OMIM id

8. Term Project Proposal Presentation 7 Dermatology 2006 SNU Dermatolory Lab 7 Result In the Searched data If click the OMIMlink, If click the Genelocus,

9. Term Project Proposal Presentation 8 Dermatology 2006 SNU Dermatolory Lab 8 Discussion - Skin database can be used to search genetic disorders in skin. - The information in this database is easier to see and understand through visualization datas and picture informations than previous OMIM DB. - DB is not linked to the web. - But this skin DB have limitations.  Most part of the information in DB exist in OMIM DB.  Earning the pictures about genetic disorder is difficult. ( shortage of knowledge)