1. Bradley Moore Natural Products, Genomics, Drug Discovery Currently funded projects: 1. Bioengineering marine antibiotics (NIAID – R01) 2. Biosynthesis and mechanism of proteasome inhibitor drugs (NCI – R01) 3. Developing new genome mining technology (NIGMS – R01 with Dorrestein) 4. Mining marine bacterial genomes for new pharmaceuticals (NIGMS – R01) 5. Natural marine contaminants and human health (NIEHS & NSF – P01) Scripps Center for Oceans and Human Health – Program Director 6. Next generation antibiotics and discovery tools (Roddenberry Foundation)

2. Core Expertise Expertise: Natural products chemistryEnzymology Biosynthesis – MetabolismBacterial genetics GenomicsSynthetic biology Therapeutic areas of interest: Infectious disease – antibiotics Cancer – proteasome inhibitors Environmental toxins – PBDEs, dioxins Materials available: 1. Natural product chemical libraries 2.Synthetic biology tools 3.Engineered bacterial expression hosts SpeI XhoI KpnI

3. Proposed Collaborations with SSPPS Faculty On-going collaborations: 1. Developing new genome mining technology (NIGMS – R01 with Dorrestein) Joint group members, publications (23), grants 2.Testing new antibacterial agents (Nizet) – 3 pubs 3. Biosynthesis and MOA studies (Gerwick) – 7 pubs Proposed collaborations: 1. UCSD Natural Product Biosynthetic Biology Production Center pending $11M NIH U01 grant application with Dorrestein and Palsson (Bioengineering) – NIH Council meets on 1/22/15 Always open for new collaboration projects!