2. The microwave multifunctional
KOS
The microwave multifunctional
tissue processor
you were waiting for

3. In a fraction of the time
KOS
Tissue processing
Decalcification
Special stains
Gross hardening
Fixation
Antigen retrieval (93°C to 120°C)
In a fraction of the time

4. The first Icon driven HistoStation
KOS: Smart and Fast
The first Icon driven HistoStation

5. KOS* Multifunctional: 1 unit 6 applications
Fast: Just plug-in and process
Reliable: Sensors controlled
Flexible: User programs / Favorites
Safe: Sensors monitored
Smart: Icons driven 5

6. Multifunctional: ONE unit SIX major applications
Fulfilling all requirements set by CAP/C.L.S.I.
Fulfilling all requirements set by CAP/C.L.S.I.
Ideal substitute for “kitchen type”
microwave oven
Ideal substitute for “kitchen type”
microwave oven

7. Rapid Tissue processing
Same day results for all tissue types.
From 1 to 45 cassettes
Ideal for transplant center
Urgent biopsies
Up to 3 mm thickness
Safe. No xylene
Ethanol – isopropanol only 7

8. tissue processing time
Fast, unmatched
tissue processing time .
35 minutes
For transplant biopsies including fixation
75 minutes
For 2 mm biopsies
Add 18 min fixation
140 minutes
For 3 mm biopsies
Add 28 min fixation

9. High Quality Slides Excellent H&E, IHC and FISH
In a fraction of the time
Colonic Biopsy
H&E, x400
Adenocarcinoma Cytokaratin
CAM 5.2, x400
Breast Red-Labeled
HER2-FISH, x800
Breast, HER2
IHC, x400

10. SMART . ICONS DRIVEN MENU 2) Select number of cassettes
1) Select thickness .
2) Select number of cassettes .

11. 3) Select reagents
4) Press GO

12. 5) Press START.
That’s all
Time left will be shown on the terminal

13. Bone Marrow processing
Same day diagnosis for bone marrow trephine biopsies.
Decalcification + processing in less than 3 hours
EDTA.
Decalcification: 80 minutes
Processing: 60 minutes
Total time: 140 minutes
FORMIC ACID (10%).
Decalcification: 20 minutes
Processing: 60 minutes
Total time: 80 minutes 13

14. Rapid Bone decalcification
Up to 45 cassette – 60 Mega cassette
Hours, not days
Magnetic stirring plus microwave energy
Positively influence the equilibrium
1. Select temperature,
2. Number of cassette,
3. Decalcifyng solution
Press GO 14

16. Up to 76% time saving for staining protocols
Special Stains
Up to 16 slides
Up to 76% time saving for staining protocols 16

18. 2) Select specific stain
1) Select stains menu
2) Select specific stain

19. 3) Follow step by step indications
4) Selected program is prestored ready to use.

20. Time At Temperature Protocols
Antigen Retrieval
Time At Temperature Protocols
Up to 80 slides 20

21. Dedicated Histomodules
Decal, up to 60 Megacassette
4K, up to 4 cassette
45K, up to 45 cassette
16s, up to 16 slides
40s, up to 80 slides

22. Fixation Dedicated fixation histomodule up to 45 cassette
Select time at temperature protocol to fulfill all requirements of standardization and documentation for CAP/ASCO for HER2/ER.
Factory stored opitimized protocols at 37°C - 50°C guarantee consistent results 22

23. Gross Hardening Dedicated GHK hardening module
Efficient & rapid hardening in physiologic solution for a timely grossing
Factory stored opitimized protocols at 50°C – 65°C guarantee consistent results 23

24. Glass Pressure Reactor-120°C
GPR-120°C
SuperHeating
Antigen Retrieval
(40 slides)

26. Dedicated Histomodules
Processing & Infiltration
Resin polymerization

27. KOS EM demo

28. KOS EM demo Better Quality and TAT (2-3 days vs same day diagnosis)
Users were satisfied because fully supported during demo, installation and training
(Competitors were won also because of this)
KOS is not automatic but users understand that gives benefits in speed + quality and price

29. KOS Packed with the latest microwave and sensor technology.
Controlled by the
most advanced,
intuitive software.

31. Microwave is switched OFF if:
State of the Art
Microwave is switched OFF if:
Cavity ventilation is compromised
Solvent in cavity is above Threshold
Humidity in cavity exceeds set value
Microwave leak is detected

32. Any protocol as Favorite

33. In 3 “stainful” colors to fit the atmosphere of your laboratory
Last but not least…
In 3 “stainful” colors to fit the
atmosphere of your laboratory
Congo Red - GMS Green - Alcian Blue 33

35. KOS: 10 Good Reasons to Choose
1. Not a modified kitchen appliance
Industrial engineered, laboratory grade, microwave unit designed specifically for histology applications.
2. Easy-to-use
Why make things complicated?
Our icons driven user interface allows you to access information quickly.
Basic user maintenance.
3. Optimized protocols
Factory stored for tissue processing, decalcification, fixation,
gross hardening, special stains and EM
User’s defined protocols can be stored and, if required, included in a
“Favorites” menu for easy retrieval.
4. Fully compliant
We have always been concerned with Safety and Quality. Our laboratory grade microwaves fully comply with CAP-C.L.S.I. Guidelines.

36. 5. Full Tech support
With over 70 years of combined histology experience our applications support professionals have the answer to your questions.
6. Specimen safety
• Focused infrared automatic temperature control with laser positioning.
• Software controlled magnetic stirring for homogeneous temperature distribution
• Built-in re-generable charcoal filter on exhaust outlet
7. Lab safety
Sensors controlled operation. Built-in sensors will switch off microwave if:
• Cavity ventilation is compromised
• Solvent & Humidity in cavity is above threshold
• Microwave leak is detected
8. Full documentation
Through a USB port, data from the built-in Logbook can be easily downloaded for documentation Purposes (Q.A. - ISO G.L.P.)
9. TV 7’ monitoring for easy observation of process in cavity.
10. Unique histomodule technology for easy, safe handling of solutions while preserving the pH of the solution throughout the procedure.

37. Dual multifunctional tissue processor In a fraction of the time
Milestone Histos
Bench top microwave
Dual multifunctional tissue processor
Fixation and Tissue processing
Decalcification
Special stains
Gross hardening
In a fraction of the time

38. HISTOS line Processing performance Reagent efficiency
Environmental sensitivity
High quality results 38

39. Histos Processing Time
Thickness
35 min
(+10 min fix.)
1.15 hr
(+20 min fix.)
4.30 hr
(+60 min fix.) 39

40. Simplicity NO need to change your grossing procedure
NO need for special grossing tools
Software driven procedures
No cleaning cycles 40

41. Safety Fixation with either formalin or Milestone’s FineFIX
XYLENE free processing
Exhaust fan
Safety micro-switches
Fume sensors
Methods and process reports can be stored and exported 41

42. High throughput Histoprocessing of batches with
up to 110 standard cassettes… 42

43. up to 16 Mega and 8 SuperMega cassettes.
High throughput
…and of batches with
up to 16 Mega and 8 SuperMega cassettes. 43

44. Is in the microscopic comparison
Quality equal or better
than conventional histoprocessing for H&E, IHC, FISH
The Proof ?
Is in the microscopic comparison
Excellent results in a fraction of the time
No compromise in regard to morphology and “staining” expression

45. Benefits Vs Conventional systems
Fast processing and Same day results
Flexibility in the processing
Results equal or better than conventional
Flexibility in workflow (no peaks)
Dual processing and High throughput (110 Cass in min)
More healthy environment
Cost saving (reagents and wax disposal) 45

46. Benefits for all! Patient: - Same day results, less stress time
waiting for results
Histologist: - Improved working conditions
- Work load with less peaks
Pathologist: “Same day” and high quality slides even for difficult tissues
Administrator: - Reduced cost / cassette
- Rapid turn around time 46

47. PRESENTING ’11 HistosLINE47

48. HISTOS3 Microwave unit + single external retort (Wax module)
Parallel processing, double productivity
Up to 3mm thickness & 110 cassette
No Vacuum
Multifunctional 48

49. HISTOS3 small to medium size biopsies Ideal for Transplant center
The HISTOS3 is designed for small to medium size histology labs
small to medium size biopsies
Ideal for Transplant center 49

50. HISTOS5
Microwave unit + double external retort (Dry module, Wax module)
Parallel processing, double productivity
Vacuum, 110 cassette
Up to 7mm thickness
Multifunctional 50

51. HISTOS5 is designed for hospital laboratories
high throughput processor for same day routine
wide variety of tissues without compromising tissue block thickness.
Multifunctional unit for Pathos users 51

52. multiple functions concept
MILESTONE
concept
MILESTONE
multiple functions concept
FLEXIBILITY
Epitope Retrieval – Decalcification
Fixation – Special Staining - Gross Hardening
…in a single unit! 20 52

53. Histos: direct access 53

54. Histos: Double processing54

55. Tissue processing Processing modules up to 110 cassette
Fast protocol for urgent transplant biopsies (40’)
Processing of samples up to 7mm thickness
No xylene
No proprietary reagents
Excellent morphology, staining & IHC properties 55

56. Decalcification Processing modules for 110 cassette
Decal + processing in as little as 80minutes
No proprietary reagents – Preset protocols
Decalcification with either EDTA or acids 56

57. Special Stains Processing modules for up to 12 slides
Save up to 76% of the time vs standard method
Factory optimized stored methods guarantee consistent results
No proprietary reagents
No splashing, constant pH and temperature 57

58. Epitope Retrieval Processing modules for up to 120 slides
Factory opitimized stored methods guarantee consistent results
Standard methods at 98°C
GPR up to 120°C
No splashing, constant pH and temperature 58

59. Gross Hardening Whole organ hardening module
Physiologic solution is the reagent
Efficient & rapid hardening for a timely grossing
Factory stored opitimized methods guarantee consistent results 59