1. Factors Affecting Drug Activity
Chapter 11
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2. Which is NOT a variable that can alter blood concentration–time profiles?
Age
Gender
Body weight
Race

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4. (Hint: see page 314 of The Pharmacy Technician 5E)✖
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5. Why does the presence of disease alter the disposition and effect of some drugs in some people?
The disease can disrupt the drugs’ absorption, distribution, metabolism, and/or excretion.
A hepatic disease allows for more absorption to the kidneys.
A renal disease disrupts excretion of perspiration.
Thyroid disease affects the blood flow, causing a change in heart rhythm.

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7. (Hint: see pages 316-317 of The Pharmacy Technician 5E)✖
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8. The ability of a substance to cause renal toxicity is called
Hepatotoxicity
Nephrotoxicity
Teratogenicity
None of the above

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10. (Hint: see page 318-319 of The Pharmacy Technician 5E)✖
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11. Drug-drug interactions are commonly called
Additive, synergistic, or potentiation
Additive, alchemistic, or potentiation
Additive, atravistic, or potentiation
Additive, albinistic, or potentiation

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13. (Hint: see page 322 of The Pharmacy Technician 5E)✖
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14. Some drugs are capable of increasing the concentration of metabolizing enzymes in the liver. This process is called
Enzyme inhibition
Enzyme displacement
Enzyme induction
Enzyme filtration

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16. (Hint: see page 321 of The Pharmacy Technician 5E)✖
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17. Additive effects occur when
Two drugs with similar pharmacological actions result in an effect equal to the sum of the individual effects.
Two drugs with similar pharmacological actions produce greater effects than the sum of individual effects.
One drug with no inherent activity increases the activity of another drug, which produces an effect.
None of the above

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20. An antidote to a particular drug is given to
Block or reduce its anticoagulation effects
Block or increase its toxic effects
Block or reduce its toxic effects
Block or increase its anticoagulation effects

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22. (Hint: see page 323 of The Pharmacy Technician 5E)✖
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23. The physical presence of food in the gastrointestinal tract can alter absorption by
Improving the solubility of increasing bile secretion
Altering gastric emptying
Altering liver blood flow
Altering intestinal motility
All of the above

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25. (Hint: see page 324 of The Pharmacy Technician 5E)✖
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26. Which statement is NOT true about metabolism?
High protein diets are associated with accelerated metabolism.
High carbohydrate diets appear to decrease metabolism.
The substitution of fat calories for carbohydrate seems not to affect drug metabolism rates.
Generally, mildly or moderately undernourished adults have slower metabolism of drugs.

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29. Which statement is true about reactions of foods with certain drugs?
MAO inhibitors may produce severe hypotension and intercranial ischemia.
Certain cruciferous vegetables decrease the metabolism of a few drugs.
A patient ingesting foods containing vitamin K while taking an anticoagulant would not receive the full therapeutic effect from warfarin.
All of the above

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