1. OMICS Group Contact us at: contact.omics@omicsonline.org OMICS Group International through its Open Access Initiative is committed to make genuine and reliable contributions to the scientific community. OMICS Group hosts over 400 leading-edge peer reviewed Open Access Journals and organizes over 300 International Conferences annually all over the world. OMICS Publishing Group journals have over 3 million readers and the fame and success of the same can be attributed to the strong editorial board which contains over 30000 eminent personalities that ensure a rapid, quality and quick review process. OMICS Group signed an agreement with more than 1000 International Societies to make healthcare information Open Access.

2. OMICS Group welcomes submissions that are original and technically so as to serve both the developing world and developed countries in the best possible way. OMICS Journals are poised in excellence by publishing high quality research. OMICS Group follows an Editorial Manager® System peer review process and boasts of a strong and active editorial board. Editors and reviewers are experts in their field and provide anonymous, unbiased and detailed reviews of all submissions. The journal gives the options of multiple language translations for all the articles and all archived articles are available in HTML, XML, PDF and audio formats. Also, all the published articles are archived in repositories and indexing services like DOAJ, CAS, Google Scholar, Scientific Commons, Index Copernicus, EBSCO, HINARI and GALE. For more details please visit our website: http://omicsonline.org/Submitmanuscript.php http://omicsonline.org/Submitmanuscript.php OMICS Journals are welcoming Submissions

3. Dr. Mohammad Najafi Iran University of Medical Sciences DATA D A T A D A T A D A T A Introductory For Bioinformatics

4. DATA D A T A D A T A D A T A ِ David Roos: “We are swimming in rapidly rising of data …..how do we help from drowning?”

5. DATA D A T A D A T A D A T A ”..We must hook our individual computers into the worldwide network that gives us access to daily changes in the databases and also makes immediate our communications with each other……….. The programs that display and analyze the material for us must be improved - and we must learn to use them more effectively. Like the purchased kits, they will make our life easier, but also like the kits, we must understand enough of how they work to use them effectively…” Walter Gilbert (1991) “Towards a paradigm shift in biology” Nature News and Views 349:99

6. DATA D A T A D A T A D A T A BIOINFORMATICS The field of science is in which Biology,Computer science and Informational technology merge to form a single discipline

7. DATA D A T A D A T A D A T A Bioinformatics The creation and advancement of algorithms, computational and statistical techniques for management and analysis of biological data. Clinical Bioinformatics The hypothesis driven of a medical subject using computers and carried out with experiment.

8. To computerize the current knowledge of molecular interactions Metabolic pathways Regulatory pathways Molecular assemblies DATA D A T A D A T A D A T A Biochemical Pathways

9. DATA D A T A D A T A D A T A Current servers BioCarta KEGG MetaCyc

10. DATA D A T A D A T A D A T A Sectors and Subsectors

11. DATA D A T A D A T A D A T A Gene Databases BioCarta KEEG MetaCyc

12. DATA D A T A D A T A D A T A Protein Database PIR ( P rotein I nformation R esource) PDB ( P rotein D ata B ank) HPRD ( H uman P rotein R eference D atabase)

13. DATA D A T A D A T A D A T A ALIGNMENT

14. DATA D A T A D A T A D A T A Similarity between two sequences Global Local

15. DATA D A T A D A T A D A T A what is the best alignment between the two sequences? How should alignments be scored? How should gaps be scored?

16. DATA D A T A D A T A D A T A Scoring system for nucleic acids Match = +1 (ex; A-A, T-T, C-C, G-G) Mismatch = -1(ex; A-T, A-C, etc.)

17. DATA D A T A D A T A D A T A PAM-Point Accepted Mutation [Evolutionary Model] Margaret Dayhoff, 1978 related proteins

18. DATA D A T A D A T A D A T A BLOSUM-Block Substitutions [Conserved Sequence] Henikoff and Henikoff, 1992 conserved, ungapped regions of a protein family

19. DATA D A T A D A T A D A T A

20. D A T A D A T A D A T A

22. D A T A D A T A D A T A Alignment Tools Pairwise alignment BLAST FASTA Dot Plat Multiple sequence alignment (MSA) Induced pairwise method Progressive method Statistical Value Graph

23. DATA D A T A D A T A D A T A

24. D A T A D A T A D A T A Multiple Sequence Alignment

25. DATA D A T A D A T A D A T A Progressive Method (MSA)

26. DATA D A T A D A T A D A T A Progressive Method (Tree)

27. DATA D A T A D A T A D A T A The Fruits of analyses of the sequences that exit within the primary sources Secondary Protein Database

28. DATA D A T A D A T A D A T A PSProsite BL blocks PD Prodom PR prints IPR Interpro PF pfam Secondary Protein Database

29. DATA D A T A D A T A D A T A Gene Regulation Databases Related to compilation of DNA Elements & Protein Regulatory Factors Protein Regulatory Factors

30. DATA D A T A D A T A D A T A Promoter region The element of bind with polymerase II - EPD - EPD The sequence beyond TATA box - TRRD - TRRD -TRANCFAC -TRANCFAC Gene Regulation Databases

31. DATA D A T A D A T A D A T A Genomics Gene Prediction ab initio Homology Consensus

32. DATA D A T A D A T A D A T A Proteomics protein expression Mapping protein expression to estimate what’s actually happing in tissue following intervention

33. DATA D A T A D A T A D A T A Proteome analysis purification 1.A procedure for purification 2-DE 2-DE structural information 2.A method to determine structural information Sequencing Sequencing Ms Ms databases 3.Use of databases genebank genebank functional information 4.Prediction of functional information using annotations using annotations

34. Najafi M,Jangravi Z. Human PON promoters: from similarity to prediction of polymorphic positions within transcription factor elements. Mini Rev Med Chem. 2010 Sep;10(10):938-45. Najafi M, Roustazadeh A. Scoring of Matrix Gla protein (MGP) promoter variants within predicted transcription elements. IWBBIO 2013, 393-395. Najafi M, Alipoor B, Shabani M, Amirfarhangi A, Ghasemi H.Association between rs4673 (C/T) and rs13306294 (A/G) haplotypes of NAD(P)H oxidase p22phox gene and severity of stenosis in coronary arteries. Gene. 2012 10;499(1):213-7. Najafi M, Roustazadeh A, Alipoor B. Ox-LDL Particles: Modified components, Cellular uptake, Biological roles and Clinical assessments. Cardiovasc Hematol Disord Drug Targets. 2011 Oct 26. Najafi M, Bioinformatics Tools as Power Hypothetical Predictors. Biochem Physiol 2012 1:e113. References

35. Biochemistry & Physiology: Open Access Related Journals Biochemistry & Physiology: Open Access Related Journals  Biochemistry & Pharmacology: Open Access Biochemistry & Pharmacology: Open Access  Biochemistry & Analytical Biochemistry Biochemistry & Analytical Biochemistry  Journal of Plant Biochemistry & Physiology Journal of Plant Biochemistry & Physiology  Biochemistry & Pharmacology: Open Access Biochemistry & Pharmacology: Open Access  Biochemistry & Analytical Biochemistry Biochemistry & Analytical Biochemistry  Journal of Plant Biochemistry & Physiology Journal of Plant Biochemistry & Physiology

36.  2nd World Congress on Petrochemistry and Chemical Engineering 2nd World Congress on Petrochemistry and Chemical Engineering  3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing  2nd World Congress on Petrochemistry and Chemical Engineering 2nd World Congress on Petrochemistry and Chemical Engineering  3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing Biochemistry & Physiology: Open Access Related Conferences Biochemistry & Physiology: Open Access Related Conferences

37. OMICS Group Open Access Membership OMICS publishing Group Open Access Membership enables academic and research institutions, funders and corporations to actively encourage open access in scholarly communication and the dissemination of research published by their authors. For more details and benefits, click on the link below: http://omicsonline.org/membership.php OMICS publishing Group Open Access Membership enables academic and research institutions, funders and corporations to actively encourage open access in scholarly communication and the dissemination of research published by their authors. For more details and benefits, click on the link below: http://omicsonline.org/membership.php