1. NATURAL PRODUCTS RESEARCH
CHEMISTRY DEPARTMENT, MAKERERE UNIVERSITY

2. MAJOR RUNNING THEME SINCE 1998
BIOPROSPECTING FOR FLAVONOIDS IN UGANDAN FLORA
Main collaborator: Prof. Øyvind Andersen University of Bergen,Norway
The focus has been guided by the following questions:
Have plants been used locally for medicinal purposes?
Have plants been researched for flavonoid content before?
Are the flavonoids observed in a preliminary screening new compounds or not?
Are the plants or plant parts edible

3. Current Research Team Prof. Bernard T. Kiremire
Assoc. Prof. Robert Byamukama
Dr. Hannington Twinomuhwezi-Busitema University
Ms. Jane Namukobe
Ms. Adia Madina
Mr. Christopher Adaku-Mbarara University
Collaborators: National and International to be detailed later

4. On Going Projects in natural products 2013
1. Bioprospecting For Flavonoids In Ugandan Flora
2. Multi-disciplinary University Traditional Health Initiative (MUTHI): Building Sustainable Research Capacity on Plants for Better Public Health in Africa
Researchers:
Bernard. T. Kiremire, Robert Byamukama, Grace Nambatya,Jane Namukobe, Adia Madina, Christopher Adaku

5. On Going Projects in natural products 2013 -continued
Collaborators
University of Oslo: Prof. Berit Paulsen, Over all coordinator, Mr. Jørgen Kirksæther [Finance admin]
University of Bergen:Prof. Øyvind Andersen
University of Mali: Prof. Drissa Diallo
Joop deJong; Mrs Charlotte van’t Klooster
Oxford University: Prof.Gerry Bodeker,Dr. Merlin Willcox,
University of Western Cape: Prof.Gail Hughes,
University of orange Free state:

6. France-Uganda Research cooperation (FURC) project on plant Phytochemistry
Researchers: Bernard. T. Kiremire, Robert Byamukama, Jane Namukobe
Collaborators
John.M. Kasenene :Mountain of the Moon University
Françoise Guéritte: Institut de Chimie des Substances Naturelles, France
Vincent Dumontet : Institut de Chimie des Substances Naturelles, France
Sabrina Krief : Eco-Anthropologie et Ethnobiologie,France
Isabelle Florent :National Museum Natural History,France
John D. Kabasa : College of Veterinary Medicine, animal resources and biosecurity, Makerere university :

7. PhD based studies

8. Supervisor/collaborators
Isolation and Characterization of Anti-Bacterial Constituents of Maytenus Putterlickioides, Vernonia Glabra and Thalictrum Rhychocarpum
 PhD student
Mayeku Philip Wafula
Supervisor/collaborators
Prof. Bernard Kiremire, Makerere University
Prof. Abiy Yenesew, University of Nairobi,Kenya
Dr. Josiah Odalo, Jomo Kenyatta University
Achievements so far
2 Publications in International Journals

9. Supervisor/collaborators
Phytochemical investigation of selected plants from the family Asphodelaceae for Anti-Infective principles:
PhD student
Induli Martha
Supervisor/collaborators
Assoc. Prof. Byamukama Robert, Makerere University
Prof. Abiy Yenesew, University of Nairobi, Kenya
Achievements so far
2 Publications in International Journals

10. Phytochemical and Antiplasmodial Studies of Neoboutonia Macrocalyx L.
PhD student
Jane Namukobe, Makerere University
Supervisors
Assoc. Prof. Byamukama Robert, Makerere University
Prof. Kiremire Bernard, Makerere University
Achievements so far
2 Publications in International Journal

11. Supervisor/collaborators
Nutraceutical Potential of Some Ugandan Plants with Focus on Anthocyanins
PhD student
Christopher Adaku
Supervisor/collaborators
Assoc. Prof. Byamukama Robert, Makerere University
Prof. Kiremire Bernard, Makerere University
Prof. Øyvind Andersen,University of Bergen

12. Supervisor/collaborators
Phytochemistry of selected herbal remedies used by traditional herbalists in treatment of malaria in Uganda
PhD student
Adia Madina, Makerere University (MUTHI)
Supervisor/collaborators
Assoc. Prof. Byamukama Robert, Makerere University
Prof. Kiremire Bernard, Makerere University
PROMETRA Uganda-Association of herbalists

13. COMPLETED PROJECTS Out put
Characterization of anthocyanins from Selected Plants in Uganda
PhD Candidate
Byamukama Robert, Makerere University, PhD Thesis, currently teaching at Makerere University.
Out put
4 Publications in International Journal
Thesis Publication at Makerere University

14. COMPLETED PROJECTS
Characterization and Analysis of Some Natural Dyes from Selected Plants in Uganda.
Researcher
Wanyama Aaron Philip Guloba,
Achievements
PhD Thesis published at Makerere University.
5 Publications in International journals

15. Twinomuhwezi Hannington
COMPLETED PROJECTS
Phytochemical Investigation of Erythrina Abyssinica, Erythrina Burttii, Erythrina Melanacantha And Derris Trifoliata: Towards Malaria Control.
Researcher
Twinomuhwezi Hannington
Achievements
PhD Thesis published at Makerere University.
3 Publications in International journals
Lecturership at Busitema University.

16. COMPLETED PROJECTS
Antimalarial Activities Of Some Flavonoids And Flavonoid-Rich Plant Extracts
Researcher
Akala Miima Hoseah
Achievements
PhD Thesis published at Makerere University.
3 Publications in International journals
currently working at Kenya Medical Research Institute[KEMRI]

17. COMPLETED PROJECTS Capacity building MoUs developed
14 MSc graduates working on natural products areas (medicinal and flavonoids).
4 PhD graduates working on natural products
32 publications in International journals
MoUs developed
MoU with PROMETRA Uganda, process completed
MoU with MUMETHA, on-going

18. Capacity building in terms human resource
CONTRIBUTION
Capacity building in terms human resource
several graduates from Natural products
Completed: 4PhDs, 14MSc
Ongoing: 5PhDs, 3MSc
Contribution to science knowledge/flavoinoid chemistry
30 novel compounds have been characterized together with several known compounds.
HPLC, GC-MS, Small equipments for isolation of natural products.

19. FUTURE PROJECTS
Improvement of Selected Anti-malarial Herbal Medicines Through Identification of Bioactive Compounds and Development of Standardised Formulation Methods
Development of Antioxidants and Flavonoids as food supplements from indigenous plant sources
The Potential of Natural Dyes from Selected Indigenous Dye-Yielding Plants as Substitutes for Synthetic Dyes.
Pesticide properties of Plants and Their Potential in Crop Disease Control

20. SIDA phase IV
Concept was submitted based on the four topics in our future projects
PI on the concept is Assoc. Prof. whom Prof. Kiremire has mentored through the previous Projects
Required assistance.
possible collaborators from SWEDEN on the above areas of natural products

21. CHALLENGES FUNDING EQUIPMENT
Lack of local funding from University or Government, and this sometimes creates discontinuity when the project ends and you have no other project.
EQUIPMENT
Research funding usually not enough to buy big equipment vital in Natural products research such as MS and NMR.
Much reliance on collaboration in order to use large equipments.

22. ACKNOWLEDGEMENTS NUFU SIDA University of Bergen Makerere university
Thank you for listening