1. Anticoagulant, Antiplatelet, and Thrombolytic Drugs
Chapter 50
Anticoagulant, Antiplatelet, and Thrombolytic Drugs
Copyright (c) Elsevier Inc. All rights reserved.

2. Anticoagulant, Antiplatelet, and Thrombolytics Drugs
Hemostasis
Stage 1—formation of platelet plug
Platelet aggregation
Stage 2—coagulation
Intrinsic system
Extrinsic system

3. Heparin Rapid-acting anticoagulant Uses Pulmonary embolism
Stroke evolving
Vein thrombosis
Adverse effects
– Hemorrhage
– Heparin-induced thrombocytopenia
– Hypersensitivity reactions
Protamine
APTT

4. Warfarin (Coumadin) Oral anticoagulant Antagonist vitamin K
Affects synthesis—factors VII, IX, X, and prothrombin
Uses
Long-term prophylaxis of thrombosis
Adverse effects
– Hemorrhage
PT link

5. Antiplatelet Drugs Aspirin (ASA) Inhibition of cyclooxygenase
Ticlopidine (Ticlid)
ADP receptor antagonists
Clopidogrel (Plavix)
ADP receptor antagonist

6. Thrombolytic Drugs Streptokinase Binds plasminogen Uses
Myocardial infarction
Deep vein thrombosis
Massive pulmonary emboli
Adverse effects
Bleeding
– Antibody production
Hypotension
Fever